News related to Zyloprim (Allopurinol) and/or conditions it is approved for
Gout: No Help From Vitamin C
Source: Medscape Today Headlines [2013.05.16]
In patients with gout, vitamin C supplementation at 500 mg/day, either alone or with allopurinol, did not reduce uric acid levels enough to be clinically significant.
Medscape Medical News
Vitamin C No Help in Gout (CME/CE)
Source: MedPage Today Nephrology [2013.05.16]
(MedPage Today) -- Vitamin C supplements didn't lower uric acid levels in patients with gout when given either alone or in combination with allopurinol, an open-label pilot study showed.
Vitamin C Does Not Lower Uric Acid Levels In Gout Patients
Source: Gout News From Medical News Today [2013.05.16]
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients with established gout...
UL Medical School Researchers Find Increased Death Risk In Patients Suffering From Gout And Elevated Uric Acid Levels
Source: Gout News From Medical News Today [2013.05.02]
A new study led by researchers at the Graduate Entry Medical School (GEMS), University of Limerick (UL) has found that people suffering from gout and elevated serum uric acid have significantly increased risks of death. In their study, individuals with a diagnosis of gout experienced a 42 % higher risk of death from all causes and a 58% higher risk of cardiovascular death...
Shedding Light On Gout: Repair Of Protein Pump Possible
Source: Gout News From Medical News Today [2013.04.10]
Johns Hopkins scientists have found out how a gout-linked genetic mutation contributes to the disease: by causing a breakdown in a cellular pump that clears an acidic waste product from the bloodstream. By comparing this protein pump to a related protein involved in cystic fibrosis, the researchers also identified a compound that partially repairs the pump in laboratory tests...
Potential For New Drugs To Treat Gout
Source: Gout News From Medical News Today [2013.03.22]
Findings from a Loyola University Chicago Stritch School of Medicine study could lead to the development of new drugs to treat gout. The study, led by Liang Qiao, MD, and his colleagues and collaborators, was published in the journal Nature Communications. Gout is caused by a buildup of uric acid around joints, typically the big toe, knee or ankles...
Genetic Insight Into 'Disease Of Kings' Offered By Gout Study
Source: Gout News From Medical News Today [2013.01.03]
Scientists have shed light on why some people are more susceptible to gout than others. A study has identified 18 new genetic variations that increase levels of uric acid in the blood, which is the main cause of the disease. High levels of uric acid form small crystals in joints and tissues, causing pain and swelling - the main symptoms of the condition once known as the 'disease of kings'...
Scientists ID New Genetic Connection for Gout
Source: MedicineNet Gout Specialty [2012.12.31]
Title: Scientists ID New Genetic Connection for Gout
Category: Health News
Created: 12/28/2012 6:36:00 PM
Last Editorial Review: 12/31/2012 12:00:00 AM
Aging Overweight Males At Increased Risk For Gout, Rheumatoid Arthritis
Source: Gout News From Medical News Today [2012.11.13]
Refuting a belief long held by many physicians, a Mayo Clinic study found that rheumatoid arthritis patients also can get gout. The research is among several studies Mayo Clinic presented at the American College of Rheumatology annual meeting in Washington...
Gout Management Is Focus of New Guidelines
Source: MedicineNet Gout Specialty [2012.10.03]
Title: Gout Management Is Focus of New Guidelines
Category: Health News
Created: 10/2/2012 4:05:00 PM
Last Editorial Review: 10/3/2012 12:00:00 AM
Eating Cherries Lowers Your Gout Attack Risk
Source: Gout News From Medical News Today [2012.09.30]
Eating cherries over a two-day period reduced the risk of gout attacks by 35%, according to a new study led by Boston University (BU) in the US that is being published in the journal Arthritis & Rheumatism...
Gout Guidelines Arm Patients And Physicians With Tools To Fight Painful Disease
Source: Gout News From Medical News Today [2012.09.28]
Gout is one of the most common forms of inflammatory arthritis, affecting nearly 4% of adult Americans...
Pseudogout
Source: MedicineNet Amyloidosis Specialty [2012.09.14]
Title: Pseudogout
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 9/14/2012 12:00:00 AM
BUSM Study Finds Gout And Hyperuricemia On The Rise In The U.S.
Source: Gout News From Medical News Today [2012.06.28]
Researchers from Boston University School of Medicine (BUSM) have found that the incidence of gout and hyperuricemia (high uric acid levels) in the U.S. has risen significantly over the last 20 years and is associated with major medical disorders like hypertension and chronic kidney disease...
Gout And Hyperuricemia On The Rise In The U.S.
Source: Gout News From Medical News Today [2012.06.28]
Boston University School of Medicine (BUSM) researchers have found that the incidence of gout and hyperuricemia (high uric acid levels) in the U.S. has risen significantly over the last 20 years and is associated with major medical disorders like hypertension and chronic kidney disease...
Gout Risk From Purine Rich Foods
Source: Gout News From Medical News Today [2012.05.31]
Foods rich in purines, particularly those found in meat and seafood, quintuple the immediate risk of a gout flare-up, according to research published online in the Annals of the Rheumatic Diseases. While the anecdotal evidence has suggested that purine rich foods can trigger gout attacks, it hasn't been clear whether they prompt flare-ups in the short term, say the authors...
Gout
Source: MedicineNet Bunions Specialty [2012.05.31]
Title: Gout
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/31/2012 12:00:00 AM
Clinical Trial Demonstrates That Rilonacept Significantly Reduces Gout Flares
Source: Gout News From Medical News Today [2012.01.09]
A phase II clinical trial found that rilonacept, an inhibitor of the protein interleukin-1 (IL-1), significantly reduced acute gout flares that occur when initiating uric acid-lowering therapy...
Gout Flares - Rilonacept Effective, According To Clinical Trial
Source: Gout News From Medical News Today [2012.01.06]
According to a phase II clinical trial, the drug rilonacept, which inhibits the protein interleukin-1 (IL-1), substantially reduces acute gout flares that occur at the start of uric acid-reducing therapy and is noted to be generally well tolerated with no serious infections or serious adverse events occurring in relation to the treatment...
Drug Already on Market May Be a Boon to Gout Patients
Source: MedicineNet allopurinol Specialty [2012.01.06]
Title: Drug Already on Market May Be a Boon to Gout Patients
Category: Health News
Created: 1/6/2012 11:01:00 AM
Last Editorial Review: 1/6/2012 12:00:00 AM
Preventing Gout Flare Ups In Patients With Renal Impairment - Dosing Guidance
Source: Gout News From Medical News Today [2011.11.09]
Results from a new pharmacokinetic (PK) study presented at the annual meeting of the American College of Rheumatology (ACR) provide new evidence-based guidance for healthcare providers on using colchicine for gout flare prophylaxis in the presence of renal impairment...
Gout Cases Missed By Traditional Tests Often Detected By CT Scans
Source: Gout News From Medical News Today [2011.11.07]
X-ray images known as CT scans can help confirm gout in patients who are suspected of having the painful condition but receive negative results from traditional tests, a Mayo Clinic study has found. The type of CT scan analyzed, dual-energy computed tomography, is also valuable for diagnosing people who cannot be tested with the typical method of drawing fluid from joints, researchers found...
Unsuitable Footwear Linked To Foot Impairment And Disability In Gout Patients
Source: Gout News From Medical News Today [2011.10.04]
New research shows that use of poor footwear is common among patients with gout. According to the study published in Arthritis Care & Research, a peer-reviewed journal of the American College of Rheumatology (ACR), gout patients who make poor footwear choices experienced higher foot-related pain, impairment and disability...
Gout Pictures Slideshow: Watch & Learn About Gout
Source: MedicineNet Hydroxyapatite Specialty [2011.09.09]
Title: Gout Pictures Slideshow: Watch & Learn About Gout
Category: Slideshows
Created: 6/6/2008 12:00:00 AM
Last Editorial Review: 9/9/2011 12:00:00 AM
Pegloticase, Alternative Treatment For Chronic Gout Shows Greater Improvement In Symptoms
Source: Gout News From Medical News Today [2011.08.17]
According to a study in the August 17 issue of JAMA, patients with severe, chronic gout who took pegloticase for 6 months as an alternative to conventional gout treatment that some patients may not respond to, showed greater improvements of uric acid levels as well as physical function and quality of life...
New Drug Aids Gout Patients Not Helped By Standard Treatments
Source: Gout News From Medical News Today [2011.08.17]
Injections of pegloticase, a modified porcine enzyme, can produce significant and sustained clinical improvements in 2 out of 5 patients with chronic gout that is resistant to conventional therapies, researchers report in the August 17, 2011, issue of JAMA...
Pegloticase Helps Patients With Severe, Chronic Gout
Source: Gout News From Medical News Today [2011.08.16]
Individuals with severe, chronic gout who have not responded to conventional treatment may benefit from six-months' worth of pegloticase treatment. Researchers from Duke University Medical Center, Durham, N.C., reported in JAMA (Journal of the American Medical Association) that individuals experienced better levels of uric acid as well as physical function, quality of life, and less pain...
Gout Quiz: Test Your Medical IQ
Source: MedicineNet allopurinol Specialty [2011.08.12]
Title: Gout Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 1/26/2011 6:55:00 PM
Last Editorial Review: 8/12/2011 7:26:07 PM
Caffeine May Trigger Gout Attacks
Source: MedicineNet allopurinol Specialty [2010.11.12]
Title: Caffeine May Trigger Gout Attacks
Category: Health News
Created: 11/12/2010 11:00:00 AM
Last Editorial Review: 11/12/2010 12:00:00 AM
Picture of Gout
Source: MedicineNet allopurinol Specialty [2010.03.25]
Title: Picture of Gout
Category: Images
Created: 3/25/2010 2:19:00 PM
Last Editorial Review: 3/25/2010 2:19:37 PM
Gout History
Source: MedicineNet History Of Medicine Specialty [2004.12.30]
Title: Gout History
Category: Health Facts
Created: 12/31/1997
Last Editorial Review: 12/30/2004
Hot On The Trail Of Metabolic Diseases And Antibiotic Resistance
Source: Gout News From Medical News Today [2012.03.29]
ABC transporters are membrane proteins that actively pump a wealth of molecules across the membrane. Over 40 different ABC transporters perform vital functions in humans. Genetic defects in ABC transporters can trigger metabolic diseases such as gout, neonatal diabetes or cystic fibrosis, and certain ABC transporters also cause resistance to a wide range of drugs...
Regeneron Announces FDA Acceptance Of ARCALYST® (rilonacept) Supplemental Biologics License Application For Review
Source: Gout News From Medical News Today [2011.11.26]
Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) announced that the U.S. Food and Drug Administration (FDA) has accepted for review the Company's supplemental Biologics License Application (sBLA) for ARCALYST Injection for Subcutaneous Use for the prevention of gout flares in patients initiating uric acid-lowering therapy...
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