Media Articles Related to Zyflo (Zileuton)
CDC: Highest Asthma Rates in Healthcare Workers
Source: MedPageToday.com - medical news plus CME for physicians [2016.12.02]
(MedPage Today) -- State-specific analysis showed wide variation in asthma prevalence by industry
Asthma Symptoms, Causes, and Medications
Source: MedicineNet Asthma Complexities Specialty [2016.11.30]
Title: Asthma Symptoms, Causes, and Medications
Created: 11/12/2009 5:02:00 PM
Last Editorial Review: 11/30/2016 12:00:00 AM
Management of Acute Loss of Asthma Control: The Yellow Zone
Source: Medscape Allergy & Clinical Immunology Headlines [2016.11.29]
What are the recommended treatment options for asthma patients in the 'yellow zone'?
Journal for Nurse Practitioners
Australia Storm Triggers 'Unprecedented' Pollen Asthma Attacks
Source: Medscape Allergy & Clinical Immunology Headlines [2016.11.28]
A storm in the Australian city of Melbourne triggered thousands of pollen allergy asthma attacks which killed at least four people and on Thursday was labeled a health emergency of 'unprecedented scale.'
Reuters Health Information
Mouse Allergen in Schools Tied to Worse Asthma for Kids
Source: Medscape Allergy & Clinical Immunology Headlines [2016.11.27]
Mouse allergens in school buildings may be an important environmental factor aggravating kids' asthma, a U.S. study suggests.
Reuters Health Information
Published Studies Related to Zyflo (Zileuton)
Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. [2011.02]
RATIONALE: Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations. OBJECTIVE: We sought to test the safety and efficacy of adding oral zileuton (a 5-lipoxygenase inhibitor) to usual treatment for acute exacerbations of COPD requiring hospitalization... CONCLUSIONS: While oral zileuton during COPD exacerbations that require hospital admission is safe and reduces urinary LTE(4) levels, we found no evidence suggesting that this intervention shortened hospital stay, with the limitation that our sample size may have been insufficient to detect a modest but potentially meaningful clinical improvement.
Randomized trial of zileuton for treatment of COPD exacerbations requiring
requiring hospitalization... CONCLUSIONS: While oral zileuton during COPD exacerbations that require
Efficacy of zileuton controlled-release tablets administered twice daily in the treatment of moderate persistent asthma: a 3-month randomized controlled study. [2007.08]
BACKGROUND: A controlled-release (CR) formulation of zileuton was developed to simplify administration from 600 mg 4 times daily (Zyflo) to 1,200 mg twice daily. OBJECTIVE: To evaluate the efficacy of zileuton CR, two 600-mg tablets twice daily, compared with placebo... CONCLUSIONS: Treatment with zileuton CR, 1,200 mg twice daily, resulted in a significant improvement in asthma control, and the safety and efficacy profile was similar to that observed with zileuton IR, 600 mg 4 times daily (Zyflo).
Clinical pattern of zileuton-associated liver injury: results of a 12-month study in patients with chronic asthma. 
OBJECTIVE: Zileuton is a 5-lipoxygenase inhibitor approved by the US FDA in 1996 for the treatment of asthma in adults and children. During phase II/III clinical trials, zileuton was generally well tolerated, although elevations in ALT and AST levels were noted in some patients, and a single treated patient developed hepatocellular jaundice. To more fully characterise the hepatic effects of zileuton, and to establish appropriate monitoring guidelines, a 12-month open-label, safety surveillance study was conducted prior to FDA approval... CONCLUSIONS: This study established that liver chemistry monitoring is most effective in detecting elevation of ALT levels during the first 3 months of zileuton therapy and that with appropriate monitoring the risk of irreversible liver injury appears to be low.
Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects. [2006.02]
BACKGROUND: Inhalation of swine house dust induces acute airway inflammation and increased bronchial responsiveness in healthy subjects. OBJECTIVE: The aim of the study was to investigate whether 5-lipoxygenase products such as leukotrienes may have a role in this reaction... CONCLUSIONS: Pre-treatment with clinically recommended doses of the 5-lipoxygenase inhibitor zileuton did not affect the increase of bronchial reactivity induced by swine dust exposure. The intervention totally abolished the LTB(4) release in NAL fluid, but only partially inhibited the formation of leukotrienes as monitored by urinary levels. The enhanced increase of neutrophils and IL-6 in peripheral blood in the zileuton group, suggests that inhibition of 5-lipoxygenase may have pro-inflammatory effects.
Clinical Trials Related to Zyflo (Zileuton)
Evaluating the Safety of Zileuton (Zyflo�) in Combination With Dasatinib (Sprycel�) in Chronic Myelogenous Leukemia [Recruiting]
Prospective nonrandomized phase I study
The purpose of this study is to determine safety and efficacy of zileuton when added to
dasatinib in patients with chronic myelogenous leukemia (CML).
Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML. [Terminated]
The leukemic stem cells (LSCs) are cells that self- renew and give rise to leukemia.
Eradication of LSC is required for cure. In chronic myelogenous leukemia (CML) LSCs are not
eradicated by imatinib (Gleevec) alone. Recent discovery by Dr. Shaoguang Li at University
of Massachusetts indicates that the LSCs can be targeted by a new drug zileuton (Chen et al.
Nature Genetics 2009; 41: 783-792). Zileuton (approved for asthma) will be tested in a
combination with Gleevec. This combination has not been used previously to treat leukemia.
This is a Phase I study. The goal of this research is to evaluate the safety of the standard
anti-cancer drug imatinib and experimental drug zileuton.
Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers [Not yet recruiting]
This randomized phase II trial studies the effects of aspirin and zileuton on genes related
to tobacco use in current smokers. Smokers are at increased risk for developing lung and
other cancers. Aspirin and zileuton may interfere with genes related to tobacco use and may
be useful in preventing lung cancer in current smokers.
Trial of Zileuton CR in Children and Adults With Sickle Cell Disease [Completed]
The purpose of this research study is to test the safety of Zileuton and see what effects
(good and bad) it has on you, other children and adults with Sickle Cell Disease (SCD). The
investigators also want to see how Zileuton is handled by your body at different doses.
Zileuton is a drug that is approved by the Food and Drug Administration (FDA) for the
treatment of asthma for people age 12 and older. The FDA has not approved Zileuton for the
treatment of SCD, so it is being studied as an investigational drug for SCD through an
application to the FDA. In asthma patients, Zileuton helps by reducing inflammation. This
study will see if Zileuton helps to reduce inflammation associated with SCD.
Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers [Completed]
The goal of this clinical research study is to learn how zileuton alone or the combination
of zileuton and celecoxib may affect certain chemicals in the body that may be linked with a
risk for smoking-related lung disease. These effects will be measured by a urine test