Zyflo CR (Zileuton) - Summary

ZYFLO CR SUMMARY

Zileuton is an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid.

ZYFLO CR is indicated for the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older.

ZYFLO CR is not indicated for use in the reversal of bronchospasm in acute asthma attacks. Therapy with ZYFLO CR can be continued during acute exacerbations of asthma.

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ZYFLO CR NEWS HIGHLIGHTS

Media Articles Related to Zyflo CR (Zileuton)

Researchers link C-section babies to asthma risk (Reuters)
Source: Y! Health Asthma News [2008.12.01]

Asthma inhalers to go 'green' on Dec. 31 (AP)
Source: Y! Health Asthma News [2008.12.01]

Experts Urge Change In Asthma Management
Source: Respiratory / Asthma News From Medical News Today [2008.11.29]

The Brussels Declaration: The Need For Change In Asthma Management
Source: Respiratory / Asthma News From Medical News Today [2008.11.27]

Obesity, lack of exercise reported in asthmatics (Reuters)
Source: Y! Health Asthma News [2008.11.25]

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Published Studies Related to Zyflo CR (Zileuton)

Efficacy of zileuton controlled-release tablets administered twice daily in the treatment of moderate persistent asthma: a 3-month randomized controlled study. [2007.08]

Zileuton added to low-dose inhaled beclomethasone for the treatment of moderate to severe persistent asthma. [2007.06]

The safety and efficacy of zileuton controlled-release tablets as adjunctive therapy to usual care in the treatment of moderate persistent asthma: a 6-month randomized controlled study. [2007.05]

Clinical pattern of zileuton-associated liver injury: results of a 12-month study in patients with chronic asthma. [2007]

Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects. [2006.02]

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Clinical Trials Related to Zyflo CR (Zileuton)

Zileuton to Treat Adults With Chronic Obstructive Pulmonary Disease (The LEUKO Study) [Recruiting]

PF-04191834 Single Dose Bronchodilatory Study In Asthma. [Recruiting]

Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome [Recruiting]

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