Zydone (Hydrocodone Bitartrate / Acetaminophen) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The most frequently reported adverse reactions are light-headedness, dizziness, sedation, nausea and vomiting. These effects seem to be more prominent in ambulatory than in non-ambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down.

Other adverse reactions include:

Central Nervous System

Drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, psychic dependence, mood changes.

Gastrointestinal System

Prolonged administration of ZYDONE (hydrocodone bitartrate and acetaminophen tablets) may produce constipation.

Genitourinary System

Ureteral spasm, spasm of vesical sphincters and urinary retention have been reported with opiates.

Respiratory Depression

Hydrocodone bitartrate may produce dose-related respiratory depression by acting directly on brain stem respiratory center (see OVERDOSAGE).

Special Senses

Cases of hearing impairment or permanent loss have been reported predominantly in patients with chronic overdose.

Dermatological

Skin rash, pruritus.

The following adverse drug events may be borne in mind as potential effects of acetaminophen: allergic reactions, rash, thrombocytopenia, agranulocytosis.

Potential effects of high dosage are listed in the OVERDOSAGE section.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO ZYDONE

Possible Zydone side effects / adverse reactions in 35 year old female

Reported by a physician from United States on 2007-02-16

Patient: 35 year old female

Reactions: Glaucoma, Abdominal Pain Upper, Tarsal Tunnel Syndrome, Neuropathy Peripheral, Malaise, Thrombophlebitis Superficial, Dizziness, Bronchospasm, Resorption Bone Increased, Blood Creatinine Increased, Cough, Pain in Extremity, Cholelithiasis, Osteoarthritis, Renal Failure, Vestibular Disorder, Vasculitis, Purpura Senile, Bronchitis, Arthritis, Deep Vein Thrombosis, Arthropod Bite, Vertigo Positional

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Advair Diskus 100/50
    Indication: Drug USE FOR Unknown Indication

Augmentin '125'
    Dosage: 1750mg per day
    Indication: Drug USE FOR Unknown Indication

Fluticason
    Indication: Drug USE FOR Unknown Indication

Bupropion Hydrochloride
    Dosage: 300mg unknown

Xanax
    Dosage: 1mg three times per day
    Indication: Stress
    Start date: 1985-01-01

Zyrtec
    Indication: Multiple Allergies

Latanoprost
    Indication: Drug USE FOR Unknown Indication

Dexamethasone
    Indication: Drug USE FOR Unknown Indication

Carisoprodol
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Clotrimazole
    Indication: Drug USE FOR Unknown Indication

Clonazepam

Trazodone Hydrochloride
    Indication: Drug USE FOR Unknown Indication

Gabapentin

Fluoxetine Hydrochloride
    Indication: Drug USE FOR Unknown Indication

Atenolol
    Dosage: 50mg per day

Meloxicam
    Indication: Drug USE FOR Unknown Indication

Zydone
    Indication: Drug USE FOR Unknown Indication

Olmesartan Medoxomil
    Dosage: 40mg per day

Allegra D 24 Hour
    Indication: Drug USE FOR Unknown Indication

Mometasone Furoate
    Indication: Drug USE FOR Unknown Indication

Candesartan Cilexetil
    Indication: Drug USE FOR Unknown Indication

Lansoprazole
    Indication: Drug USE FOR Unknown Indication

Fluconazole
    Indication: Drug USE FOR Unknown Indication

Esomeprazole Magnesium
    Indication: Drug USE FOR Unknown Indication

Lotrisone
    Indication: Drug USE FOR Unknown Indication

Rizatriptan Benzoate
    Indication: Drug USE FOR Unknown Indication

Lomotil
    Indication: Drug USE FOR Unknown Indication

Ketoconazole
    Dosage: 200mg per day
    Indication: Drug USE FOR Unknown Indication

Sinemet
    Indication: Drug USE FOR Unknown Indication

Tramadol HCL
    Indication: Drug USE FOR Unknown Indication

Metaxalone

Bactrim DS
    Dosage: 2u unknown
    Indication: Drug USE FOR Unknown Indication

Pethidine Hydrochloride
    Indication: Drug USE FOR Unknown Indication

Percocet
    Indication: Drug USE FOR Unknown Indication

Codiclear
    Indication: Drug USE FOR Unknown Indication

Quinine
    Indication: Drug USE FOR Unknown Indication

Moxifloxacin Hydrochloride
    Indication: Drug USE FOR Unknown Indication

Rofecoxib
    Indication: Drug USE FOR Unknown Indication

Cefazolin
    Dosage: 500mg per day
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Duratuss
    Indication: Drug USE FOR Unknown Indication

Lortab
    Indication: Drug USE FOR Unknown Indication

Erythromycin
    Dosage: 500mg per day
    Indication: Drug USE FOR Unknown Indication

Cephalexin Monohydrate
    Dosage: 1500mg per day
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Mupirocin
    Administration route: Topical
    Indication: Drug USE FOR Unknown Indication

Oseltamivir
    Dosage: 150mg per day
    Indication: Drug USE FOR Unknown Indication

Endal-HD
    Indication: Drug USE FOR Unknown Indication

Triamcinolone Acetonide
    Indication: Drug USE FOR Unknown Indication

Omeprazole
    Indication: Drug USE FOR Unknown Indication

Exgest LA
    Dosage: 2u unknown
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Mescolor
    Dosage: 2u unknown
    Indication: Drug USE FOR Unknown Indication

Triazolam
    Dosage: .25mg per day
    Indication: Drug USE FOR Unknown Indication

Lorcet-HD
    Dosage: 2u unknown
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Econazole Nitrate
    Indication: Drug USE FOR Unknown Indication

Arthrotec
    Dosage: 150mg per day
    Indication: Drug USE FOR Unknown Indication

Diazepam
    Indication: Drug USE FOR Unknown Indication

Celecoxib
    Dosage: 200mg per day
    Indication: Pain

Sucralfate
    Indication: Drug USE FOR Unknown Indication

Lasix
    Dosage: 40mg per day

Verapamil
    Dosage: 120mg per day

Metoprolol Succinate

Lisinopril

Bisoprolol Fumarate

Amlodipine
    Dosage: 5mg per day

Losartan Potassium

Covera-HS
    Start date: 2002-01-01

Possible Zydone side effects / adverse reactions in 35 year old female

Reported by a physician from United States on 2007-04-11

Patient: 35 year old female

Reactions: Glaucoma, Drug Interaction, Tarsal Tunnel Syndrome, Neuropathy Peripheral, Thrombophlebitis Superficial, Blood Cholesterol Increased, Dizziness, Resorption Bone Increased, Blood Sodium Decreased, Blood Alkaline Phosphatase Increased, Phlebitis, Blood Chloride Decreased, Alanine Aminotransferase Increased, Cholelithiasis, Osteoarthritis, Renal Failure, Vestibular Disorder, Aspartate Aminotransferase Increased, Vasculitis, Purpura Senile, Bronchitis, Arthritis, Deep Vein Thrombosis, Vertigo Positional

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Sucralfate

Zebeta

Alprazolam
    Dosage: 3 mg

Dexamethasone 0.5mg TAB

Clotrimazole

Clonazepam
    Indication: Muscle Spasms

Trazodone HCL

Gabapentin

Fluoxetine Hydrochloride

Atenolol
    Dosage: 50 mg
    Indication: Hypertension

Amlodipine
    Dosage: 5 mg
    Indication: Hypertension

Cephalexin
    Dosage: 1500mg, oral
    Administration route: Oral

Diazepam

Econazole Nitrate

Erythromycin
    Dosage: 500 mg

Fluconazole

Lansoprazole

Lisinopril

Losartan Potassium

Meloxicam

Omeprazole

Quinine Sulfate

Tramadol HCL

Triazolam

Verapamil
    Dosage: 120mg
    Indication: Hypertension

Advair Diskus 100/50

Bupropion HCL

Cetirizine HCL

Augmentin '125'

Fluticasone Propionate

Latanoprost

Carisoprodol

Zydone

Allegra-D 12 Hour

Mometasone Furoate

Candesartan Cilexetil

Esomepromazole

Lotrisone

Rizatriptan Benzoate

Lomotil

Ketoconazole

Sinemet

Metaxalone

Pethidine Hydrochloride

Percocet

Bactrim DS

Codiclear (Gualifenesin+hydrocodone Bitartrate)

Moxifloxacin Hydrochloride

Rofecoxib

Cefazolin Sodium

Duratruss (Guaifenesin+pseudoephedrine Hydrochloride)

Lortab

Mupirocin

Oseltamivir

Endal-HD (Chlorpheniramine Maleate/hydrocodone Bitartrate+phenylephrin

Triamcinolone Acetonide

Exgest LA (Guaifenesin+phenylpropanolamine)

Mescolor (Chlorphenamine+pseudoephedrine)

Lorcet-HD

Econazole Nitrate

Arthrotec

Celecoxib

Lasix

Metoprolol Succinate

Olmesartan Medoxomil