Zyban (Bupropion Hydrochloride) - Summary

ZYBAN SUMMARY

ZYBAN (bupropion hydrochloride) Sustained-Release Tablets are a non-nicotine aid to smoking cessation. ZYBAN is chemically unrelated to nicotine or other agents currently used in the treatment of nicotine addiction. Initially developed and marketed as an antidepressant (WELLBUTRIN® [bupropion hydrochloride] Tablets and WELLBUTRIN SR® [bupropion hydrochloride] Sustained-Release Tablets), ZYBAN is also chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. It is (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride.

ZYBAN is indicated as an aid to smoking cessation treatment.

See all Zyban indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Zyban (Bupropion)

Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects. [2015]
3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases dopamine and norepinephrine by investigating.

Bupropion in adults with Attention-Deficit/Hyperactivity Disorder: a randomized, double-blind study. [2014]
Attention-Deficit/Hyperactivity Disorder is one of the most common mental disorders in childhood, and it continues to adulthood without proper treatment. Stimulants have been used in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) for many years, and the efficacy of methylphenidate in the treatment of adults with ADHD has been proven to be acceptable according to meta-analysis studies.

SSRI versus bupropion effects on symptom clusters in suicidal depression: post hoc analysis of a randomized clinical trial. [2013]
CONCLUSIONS: The results require replication but suggest a pathway by which

Bupropion for smoking cessation in patients hospitalized with acute myocardial infarction: a randomized, placebo-controlled trial. [2013]
patients with acute myocardial infarction (AMI)... CONCLUSIONS: Two-thirds of patients return to smoking by 12 months after AMI.

The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence. [2013]
cognitive-behavioral mood management therapy... CONCLUSIONS: VNTR by treatment interaction differences between these and previous

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Clinical Trials Related to Zyban (Bupropion)

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban [Terminated]
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation. Sleep disturbances are a significant problem for smokers who are trying to quit smoking. Smokers may be more likely to have sleep problems and both nicotine withdrawal and agents used to aid smoking cessation (e. g., pharmacotherapies) may disrupt sleep. Lunesta (eszopiclone) is a medication that has been approved by the FDA to treat insomnia. Eszopiclone's efficacy for treating insomnia makes it a promising agent for treating nicotine withdrawal-related symptoms of sleep disturbance. This study will be 7 weeks duration. All participants will begin taking Zyban at the beginning of week 1 and will be asked to try to quit smoking at the beginning of week 2. Participants will also begin to take Lunesta or matched placebo (3 mg qd x 6 weeks) on the target quit date at the beginning of week 2. All subjects will receive eight (8) weekly sessions of brief individual supportive smoking cessation counseling. Hypothesis: It is hypothesized that significantly fewer sleep problems will be reported by participants taking Lunesta as compared to placebo. Specifically, it is expected that participants taking Lunesta will report less difficulty falling and staying asleep, higher sleep quality, and less insomnia-related fatigue and distress than participants taking placebo.

Bupropion Depression [Recruiting]
Determine bioequivalence between branded and generic bupropion extended release (XL) products (and between generic products) at steady state in patients with major depressive disorder.

STOP Study: Effectiveness of Zyban in a Clinical Population [Active, not recruiting]
Despite the significant health, social and economic costs of cigarette smoking, 17% of Ontarians still currently smoke. Use of smoking cessation pharmacotherapy such as Zyban (bupropion HCl) has been shown to double quit rates but such medications are under-utilized by smokers attempting to quit. It has been suggested that the high price of pharmacotherapy may act as a barrier to accessing such treatment. The main objective of this study is to evaluate the methods and effectiveness of providing smokers who want to quit with 8 weeks of free Zyban in combination with smoking cessation counselling through family health teams and community health centres across the province. Hypothesis: Ontario smokers who receive 8-weeks of free bupropion in combination with brief counselling will have higher smoking cessation rates than the standard population cessation rates.

Bupropion for Smoking Cessation During Pregnancy [Recruiting]
This is a prospective, double-blind placebo-controlled randomized controlled trial of the preliminary safety and efficacy of bupropion SR in combination with behavioral counseling for smoking cessation during pregnancy.

Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers [Completed]
Previous results from the investigators' Center have shown that combination treatment with Chantix and Zyban is more successful in helping men quit smoking. The investigators hope to replicate these findings with this study.

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Reports of Suspected Zyban (Bupropion) Side Effects

Urticaria (6),  Drug Abuse (4),  Pain (3),  Drug Interaction (3),  DRY Mouth (3),  Depression (3),  Drug Hypersensitivity (3),  Anxiety (3),  Insomnia (3),  Confusional State (2), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Zyban review by 38 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Smoking Cessation
Dosage & duration:		150mg taken twice daily for the period of 4 Months
Other conditions:		None
Other drugs taken:		Birth Control
		Reported Results
Benefits:		The drug did exactly what it was supposed to do. It completely eliminated all nicotine cravings leaving only the psychological aspect to worry about. So if I kept myself busy, the thought of smoking would never even enter my mind.
Side effects:		For the first week or so, I was slightly hyperactive and had some trouble sleeping. That problem went away with some adjustment in the time I took the drug as well as with my bodies assimilation of the drug. I also had a mildly bad taste in my mouth. That too faded away.
Comments:		I expressed to my doctor a desire to try this drug to quit smoking. She prescribed it to me and I began taking it shortly thereafter. Before my 2 week quit date had even arrived, I noticed a marked decrease in nicotine withdrawl episodes. I just didn't need to smoke. I found I was started to smoke only when I thought I "should" - after dinner, right before bed and other habitual times. Once I stopped smoking all together, it was a relief to only have to battle my habits and not the withdrawl effects of nicotine as well.

Zyban review by 41 year old male patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		smoking
Dosage & duration:		150 mg taken twice daily for the period of 2 months
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		it has done its job and i am smoke free now for 10 weeks
Side effects:		had random dreams for about 1 week,the worst thing was not reading the side effects of drinking alcahol,on one accasion had very little to drink and was verry hung over next day not knowing if someone had spiked my drink, the second time when drinking with mates on the town totally blacked out and have no recolection of 5 to six hours of where i had been or what i had done and sleeping for nearly a day being so tired as though you have not slept for a week
Comments:		i have stopped taking them now and still not smoking but would warn all to be aware of what the side effects can be its been about 2 week off them now and still feel a bit panicky drowsy at times

Zyban review by 28 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		to quit smoking
Dosage & duration:		don't recall (dosage frequency: 1 per day) for the period of 10 days
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		none
Side effects:		My side effects were severe depression, and alteration in personality. Do not take this drug, the side effects can be severe. I had no previous issues with depression, and as soon as I started taking this drug, I developed severe depression, and changes in my personality. Thankfully, my family noticed a change, and advised me and told me to stop taking Zyban. It took 2 years to overcome the depression and over 3 years to begin to feel like myself again. Stay away from this drug! If you want to quit smoking, butt out and stick to your guns. I quit, and it wan't the Zyban. I have been smoke free for 10 years, and depression free for 7 or 8. Someone should consider a class-action suit against the company which produces this drug. Based on other reviews I have seen, I am not the only one who had these side effects.
Comments:		I took this drug to quit smoking. I am a female and was 28 years old at the time.