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Zovirax (Acyclovir Sodium) - Summary

 
 



ZOVIRAX SUMMARY

ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Capsules, Tablets, and Suspension are formulations for oral administration.

Herpes Zoster Infections: ZOVIRAX is indicated for the acute treatment of herpes zoster (shingles).

Genital Herpes: ZOVIRAX is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes.

Chickenpox: ZOVIRAX is indicated for the treatment of chickenpox (varicella).


See all Zovirax indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Zovirax (Acyclovir)

ASP2151 for the treatment of genital herpes: a randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study. [2012]
replication... CONCLUSIONS: Three-day or single-day courses of ASP2151 appear to be effective

Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial. [2012]
mother-to-child transmission (PMTCT) interventions is unknown... CONCLUSIONS: Valacyclovir significantly decreased early breast milk and plasma

Oral acyclovir suppression and neurodevelopment after neonatal herpes. [2011.10.06]
BACKGROUND: Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease... CONCLUSIONS: Infants surviving neonatal HSV disease with CNS involvement had improved neurodevelopmental outcomes when they received suppressive therapy with oral acyclovir for 6 months. (Funded by the National Institute of Allergy and Infectious Diseases; CASG 103 and CASG 104 ClinicalTrials.gov numbers, NCT00031460 and NCT00031447, respectively.).

The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in HSV-2 seropositive women. [2011.10]
Herpes simplex virus (HSV) infections are ubiquitous in humans, but the determinants of clinical and virologic severity are not completely understood.

Patterns of herpes simplex virus shedding over 1 month and the impact of acyclovir and HIV in HSV-2-seropositive women in Tanzania. [2011.08]
OBJECTIVES: Few studies have examined the frequency and duration of genital herpes simplex virus (HSV) shedding in sub-Saharan Africa. This study describes HSV shedding patterns among a sample of HSV-2-seropositive women enrolled in a placebo-controlled trial of HSV suppressive therapy (acyclovir 400 mg twice a day) in Tanzania... CONCLUSIONS: HSV shedding was common, varying greatly by individual. Shedding rates were similar to studies in African and non-African settings. Among HIV-negative women, shedding rates were lower in the acyclovir arm; however, acyclovir did not substantially impact on HSV shedding in HIV-positive women.

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Clinical Trials Related to Zovirax (Acyclovir)

A Study to Describe the Pharmacokinetics of Acyclovir in Premature Infants (PTN_Acyclo) [Recruiting]
Acyclovir is a drug used to treat herpes simplex virus (HSV) infections in babies. Appropriate dosing of acyclovir is known for adults and children but acyclovir has not been adequately studied in full-term or premature neonates. HSV is a very serious infection in babies <6 months of age and often results in death or profound mental retardation. HSV leads to profound mental retardation in young infants because the virus attacks the central nervous system.

The investigators hypothesize that the currently recommended dose of acyclovir is inadequate to produce adequate blood levels to combat herpes simplex infection. The investigators propose to study acyclovir levels in the blood of babies who are placed on acyclovir to treat a suspected HSV infection. This will allow them to determine the appropriate dose in premature infants. This is an unmet public health need because it is likely that the drug behaves differently in premature infants than it does in term infants and older children. Premature babies have more body water and less body tissue. Their kidneys are more immature and do not function as well as full term infants. Premature neonates are also at the greatest risk from herpes infection because they have poorly functioning immature immune systems. Early and appropriate treatment with acyclovir has resulted in improved outcome in term infants.

Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS) [Completed]
To evaluate the safety of topically applied SP-303 gel and to compare the efficacy of SP-303 gel in combination with acyclovir, relative to acyclovir alone, for the treatment of recurrent Herpes Simplex Virus (HSV) 1 and 2 infections, affecting the genital, perianal and neighboring areas, in patients with AIDS.

Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease [Recruiting]
Meniere's disease is a chronic illness that affects a substantial number of patients every year worldwide. The disease is characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure. It has recently been suggested that viral etiologies specially Herpes virus might be the underlying reason. The investigators study is a randomized, double- blinded placebo-controlled clinical trial in Amiralam Hospital. In this study the primary objective is to assess efficacy of Acyclovir in control of symptoms in patients with Meniere's disease specially their vertigo attacks. Inclusion criteria would be patient's willingness to participate in the study and follow ups, being 18 years old or older, having at least 2 vertigos per month each at least 20 min, interfering with function, and not on medication for Meniere's disease for at least 3 months before the trial. They should not have any history of allergy to Acyclovir, renal insufficiency or Creatinine above 1. 5 mg/dl, hepatic enzymes more than three times normal, serious uncontrolled illness, be pregnant or nursing or have previous surgeries on Endolymphatic Sac. Participants will be randomly placed in 2 different arms getting either Acyclovir 400 mg or placebo (inert ingredient). They will take the medication for 10 days 5 times a day, then 3 times a day for next 10 days, and 2 times a day for the last 10 days. Patients will report changes in their symptoms 10 days after initiating the drug and in 1, 3, 6 month intervals.

Effectiveness of Acyclovir in Suppressing HIV Viral Load in Women Coinfected With HIV and Herpes Simplex Virus Type 2 (HSV-2) [Recruiting]
The purpose of this study is to determine whether acyclovir is effective in suppressing HIV viral load in women infected with both HIV-1 and herpes simplex virus type 2 (HSV-2) who are starting HIV treatment for the first time.

Contribution of Salivary Cortisol in the Detection of Infra-clinic Cortisol Adenoma (ACIC) [Recruiting]

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Reports of Suspected Zovirax (Acyclovir) Side Effects

Renal Failure Acute (28)Dysarthria (11)Pancytopenia (10)Encephalopathy (10)Rash (10)Altered State of Consciousness (10)Herpes Zoster (9)Pneumonia (9)Urinary Tract Infection (9)Encephalitis (8)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 12 ratings/reviews, Zovirax has an overall score of 8.75. The effectiveness score is 9.17 and the side effect score is 9.17. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Zovirax review by 58 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   herpes
Dosage & duration:   3 capsules daily taken every day for the period of 3 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   outbreaks were reduced from one every few months to one every few years
Side effects:   none that I am aware of
Comments:   just swallow one capsule three times per day

 

Zovirax review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   fever blisters
Dosage & duration:   1600 mg taken twice daily for the period of 1 day
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   If I took the Zovirax at the first sign of tingling it would prevent an outbreak. If I waited I would still get blisters but they would only last 2-3 days.
Side effects:   no side effects
Comments:   I take 2 pills first thing and then another 2 before bed.

 

Zovirax review by 46 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Cold sores/ herpes I
Dosage & duration:   1600 Mg per day taken 4 times per day (400mg tablets) for the period of over one yar
Other conditions:   kidney scarring, chronic anemia
Other drugs taken:   none
  
Reported Results
Benefits:   For awhile it did prevent cold sores. Then I started having frequent chest pains as well as fainting spells. Now I'm finding out from an ER Physician and the Pharmacist I 1. should never have been prescribed this dosage (twice what should be prescribed in per day) and NO-ONE should take Acyclovir for this length of time either. I've been told this is the reason for my fainting spells, chest pain, low blood pressure problems, increased kidney (renal) damage, yeast infections and most recently a series of fungal infections.
Side effects:   fainting spells, chest pain, low blood pressure, further kidney damage, infections followed up with fungal infections. I now am taking 1000 mg of L-Lysiene (natural food store or grocery store) per day. It's extrememly low cost and it's very effective.
Comments:   I hope this information will help someone not go through what I've gone through. I don't have chest pain since I've quit using it after one week. I was never even given one liver functioning test on this at all and that is reccommended by the way. Good Luck and take care.

See all Zovirax reviews / ratings >>

Page last updated: 2013-02-10

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