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Zovirax (Acyclovir Sodium) - Summary

 
 



ZOVIRAX SUMMARY

ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Capsules, Tablets, and Suspension are formulations for oral administration.

Herpes Zoster Infections: ZOVIRAX is indicated for the acute treatment of herpes zoster (shingles).

Genital Herpes: ZOVIRAX is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes.

Chickenpox: ZOVIRAX is indicated for the treatment of chickenpox (varicella).


See all Zovirax indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Zovirax (Acyclovir)

Valacyclovir therapy does not reverse herpes-associated alterations in cervical immunology: a randomized, placebo-controlled crossover trial. [2014]
Herpes simplex virus type 2 (HSV-2) infection is associated with a 3-fold increase in the risk of human immunodeficiency virus (HIV) acquisition, perhaps through alterations in mucosal HIV-susceptible target cells. We performed a clinical trial to assess the impact of herpes therapy on cervical immunology in HSV-2-infected, HIV-uninfected women from Africa or the Caribbean who were living in Toronto, Canada.

ASP2151 for the treatment of genital herpes: a randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study. [2012]
replication... CONCLUSIONS: Three-day or single-day courses of ASP2151 appear to be effective

Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial. [2012]
mother-to-child transmission (PMTCT) interventions is unknown... CONCLUSIONS: Valacyclovir significantly decreased early breast milk and plasma

Oral acyclovir suppression and neurodevelopment after neonatal herpes. [2011.10.06]
BACKGROUND: Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease... CONCLUSIONS: Infants surviving neonatal HSV disease with CNS involvement had improved neurodevelopmental outcomes when they received suppressive therapy with oral acyclovir for 6 months. (Funded by the National Institute of Allergy and Infectious Diseases; CASG 103 and CASG 104 ClinicalTrials.gov numbers, NCT00031460 and NCT00031447, respectively.).

The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in HSV-2 seropositive women. [2011.10]
Herpes simplex virus (HSV) infections are ubiquitous in humans, but the determinants of clinical and virologic severity are not completely understood.

more studies >>

Clinical Trials Related to Zovirax (Acyclovir)

A Study to Describe the Pharmacokinetics of Acyclovir in Premature Infants (PTN_Acyclo) [Recruiting]
Acyclovir is a drug used to treat herpes simplex virus (HSV) infections in babies. Appropriate dosing of acyclovir is known for adults and children but acyclovir has not been adequately studied in full-term or premature neonates. HSV is a very serious infection in babies <6 months of age and often results in death or profound mental retardation. HSV leads to profound mental retardation in young infants because the virus attacks the central nervous system.

The investigators hypothesize that the currently recommended dose of acyclovir is inadequate to produce adequate blood levels to combat herpes simplex infection. The investigators propose to study acyclovir levels in the blood of babies who are placed on acyclovir to treat a suspected HSV infection. This will allow them to determine the appropriate dose in premature infants. This is an unmet public health need because it is likely that the drug behaves differently in premature infants than it does in term infants and older children. Premature babies have more body water and less body tissue. Their kidneys are more immature and do not function as well as full term infants. Premature neonates are also at the greatest risk from herpes infection because they have poorly functioning immature immune systems. Early and appropriate treatment with acyclovir has resulted in improved outcome in term infants.

Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS) [Completed]
To evaluate the safety of topically applied SP-303 gel and to compare the efficacy of SP-303 gel in combination with acyclovir, relative to acyclovir alone, for the treatment of recurrent Herpes Simplex Virus (HSV) 1 and 2 infections, affecting the genital, perianal and neighboring areas, in patients with AIDS.

Effectiveness of Acyclovir in Suppressing HIV Viral Load in Women Coinfected With HIV and Herpes Simplex Virus Type 2 (HSV-2) [Recruiting]
The purpose of this study is to determine whether acyclovir is effective in suppressing HIV viral load in women infected with both HIV-1 and herpes simplex virus type 2 (HSV-2) who are starting HIV treatment for the first time.

Contribution of Salivary Cortisol in the Detection of Infra-clinic Cortisol Adenoma (ACIC) [Recruiting]

The Safety and Effectiveness of Zidovudine Plus Acyclovir in Patients With Early HIV Infection [Completed]
This double-blind, placebo-controlled study is designed to determine the long-term safety and efficacy of concurrent oral Retrovir / Zovirax (AZT and ACV) therapy and oral AZT therapy alone, in the treatment of early symptomatic HIV infection. Efficacy will be evaluated by monitoring the incidence, severity, and time of development of opportunistic infections and other manifestations of advanced symptomatic HIV infection. The effects of the combination and single AZT therapy on immune function and viral replication will also be evaluated. Study participants will be monitored for evidence of toxicity or intolerance to concurrent AZT / ACV administration and AZT therapy alone.

more trials >>

Reports of Suspected Zovirax (Acyclovir) Side Effects

Renal Failure Acute (28)Dysarthria (11)Pancytopenia (10)Encephalopathy (10)Rash (10)Altered State of Consciousness (10)Herpes Zoster (9)Pneumonia (9)Urinary Tract Infection (9)Encephalitis (8)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 12 ratings/reviews, Zovirax has an overall score of 8.75. The effectiveness score is 9.17 and the side effect score is 9.17. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Zovirax review by 58 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   herpes
Dosage & duration:   3 capsules daily taken every day for the period of 3 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   outbreaks were reduced from one every few months to one every few years
Side effects:   none that I am aware of
Comments:   just swallow one capsule three times per day

 

Zovirax review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   fever blisters
Dosage & duration:   1600 mg taken twice daily for the period of 1 day
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   If I took the Zovirax at the first sign of tingling it would prevent an outbreak. If I waited I would still get blisters but they would only last 2-3 days.
Side effects:   no side effects
Comments:   I take 2 pills first thing and then another 2 before bed.

 

Zovirax review by 46 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Cold sores/ herpes I
Dosage & duration:   1600 Mg per day taken 4 times per day (400mg tablets) for the period of over one yar
Other conditions:   kidney scarring, chronic anemia
Other drugs taken:   none
  
Reported Results
Benefits:   For awhile it did prevent cold sores. Then I started having frequent chest pains as well as fainting spells. Now I'm finding out from an ER Physician and the Pharmacist I 1. should never have been prescribed this dosage (twice what should be prescribed in per day) and NO-ONE should take Acyclovir for this length of time either. I've been told this is the reason for my fainting spells, chest pain, low blood pressure problems, increased kidney (renal) damage, yeast infections and most recently a series of fungal infections.
Side effects:   fainting spells, chest pain, low blood pressure, further kidney damage, infections followed up with fungal infections. I now am taking 1000 mg of L-Lysiene (natural food store or grocery store) per day. It's extrememly low cost and it's very effective.
Comments:   I hope this information will help someone not go through what I've gone through. I don't have chest pain since I've quit using it after one week. I was never even given one liver functioning test on this at all and that is reccommended by the way. Good Luck and take care.

See all Zovirax reviews / ratings >>

Page last updated: 2014-11-30

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