SUMMARY
ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Cream 5% is a formulation for topical administration.
ZOVIRAX Cream is indicated for the treatment of recurrent herpes labialis (cold sores) in adults and adolescents (12 years of age and older).
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NEWS HIGHLIGHTSMedia Articles Related to Zovirax Topical (Acyclovir Topical)
Herpes Simplex Infections (Cold Sores, Non-Genital)
Source: MedicineNet Erythema Nodosum Specialty [2007.10.16]
Title: Herpes Simplex Infections (Cold Sores, Non-Genital)
Category: Diseases and Conditions
Created: 6/16/1999 7:38:00 PM
Last Editorial Review: 10/16/2007
Published Studies Related to Zovirax Topical (Acyclovir Topical)
Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial. [2009.03]
BACKGROUND: Treatment of herpes simplex labialis (HSL) has been associated with modest benefits. This difficulty results from the rapid resolution of the disease accomplished by the immune system, which narrows the window of therapeutic opportunity. The immune response is also responsible for important clinical manifestations, including oedema and pain. The dual role of immune responses (protection, pathology) is well recognized in other infectious diseases. The addition of corticosteroids to antimicrobial agents has been associated with improvement in some of these diseases. OBJECTIVE: We evaluated the combination of oral valacyclovir plus topical clobetasol compared to placebo for recurrent HSL... CONCLUSIONS: This pilot study supports the addition of topical corticosteroids to an oral antiviral agent for the treatment of HSL. Larger studies need to confirm the safety and efficacy of this approach.
Silica gel is as effective as acyclovir cream in patients with recurrent herpes labialis: results of a randomized, open-label trial. [2008]
OBJECTIVE: To compare silica gel with acyclovir cream in the treatment of recurrent herpes labialis... CONCLUSIONS: Silica gel was as effective in the treatment of recurrent herpes labialis as acyclovir and equally well tolerated and tended to take effect more quickly. Therefore, silica gel could prove a useful alternative to topical acyclovir.
A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia. [2007.01]
OBJECTIVE: The objective of this study was to assess the efficiency of topical applications of podophyllin resin (25%) (P) versus podophyllin resin (25%) together with acyclovir cream (5%) (PA) in the treatment of oral hairy leukoplakia (OHL) in accordance with the following criteria: (1) number of applications necessary for the total clinical resolution of OHL; (2) correlation between the decrease of lesion size and the number of applications; (3) total clinical resolution of OHL; and (4) clinical reevaluation 12 months after the end of treatment... CONCLUSIONS: The present study demonstrated the following: (1) P and PA topical treatments presented a similar average number of applications performed weekly; (2) both groups showed the same clinical response at 12 months post-therapy; and (3) PA presented a 100% clinical resolution and a continuous decrease in OHL size over the course of weekly applications.
Topical iontophoretic administration of acyclovir for the episodic treatment of herpes labialis: a randomized, double-blind, placebo-controlled, clinic-initiated trial. [2006.08.15]
BACKGROUND: Multiple studies of the use of acyclovir for the treatment of herpes labialis have suggested that the nominal efficacy of the topical formulation is the result of inadequate penetration of the drug into the target site of infection, the basal epidermis... CONCLUSIONS: Single-dose topical iontophoresis of acyclovir appears to be a convenient and effective treatment for cold sores and merits further clinical investigation.
Role of acyclovir gel in herpes simplex: clinical implications. [2003.07]
CONCLUSIONS: The results demonstrate that a five-fold reduction in the ACY content in liposomal gel is sufficient for the complete healing of herpetic lesions in HSV-1 and HSV-2 infection. The increased duration of topical therapy may be acceptable for patients suffering from mild herpetic lesions because of the advantage of avoiding systemic and local side effects
Clinical Trials Related to Zovirax Topical (Acyclovir Topical)
Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS) [Completed]
To evaluate the safety of topically applied SP-303 gel and to compare the efficacy of SP-303
gel in combination with acyclovir, relative to acyclovir alone, for the treatment of
recurrent Herpes Simplex Virus (HSV) 1 and 2 infections, affecting the genital, perianal and
neighboring areas, in patients with AIDS.
The Safety and Effectiveness of Zidovudine Plus Acyclovir in Patients With Early HIV Infection [Completed]
This double-blind, placebo-controlled study is designed to determine the long-term safety and
efficacy of concurrent oral Retrovir / Zovirax (AZT and ACV) therapy and oral AZT therapy
alone, in the treatment of early symptomatic HIV infection. Efficacy will be evaluated by
monitoring the incidence, severity, and time of development of opportunistic infections and
other manifestations of advanced symptomatic HIV infection. The effects of the combination
and single AZT therapy on immune function and viral replication will also be evaluated. Study
participants will be monitored for evidence of toxicity or intolerance to concurrent AZT /
ACV administration and AZT therapy alone.
A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand [Completed]
Herpes infection is an important co-factor in HIV transmission. A recent meta-analysis
demonstrated that HSV infection contributed to a 2-fold increased risk of HIV transmission.
Suppressive therapy with acyclovir has been a method proposed to reduce HIV transmission. We
are conducting a randomized controlled cross-over trial to evaluate the effect of acyclovir
suppressive therapy on HIV genital shedding in women co-infected with HIV-1 and Herpes
Simplex Virus Type-2 (HSV-2) in Thailand.
Bioequivalence Study of Aciclovir 5% Cream in Japanese Healthy Volunteers [Recruiting]
This study is designed to show bioequivalence between Current and New formulation of
Aciclovir cream 5% in keratin layer of the epidermis in Japanese Subjects
Comparison of Brovavir Versus Acyclovir in the Treatment of Herpes in HIV-Infected Patients [Completed]
To compare the efficacy of oral sorivudine (brovavir) and oral acyclovir for the treatment of
localized herpes zoster in HIV-infected patients.
HIV-infected patients are at high risk for herpesvirus infections, including varicella-zoster
virus ( VZV ) infections, also called shingles. Acyclovir, an approved drug, is widely used
to treat VZV infections in the HIV population. Since no data from controlled studies are
available to define the role of antiviral therapy for VZV infections in HIV-infected
patients, a study is needed to test the relative efficacy of brovavir, an experimental
antiviral drug, versus that of acyclovir.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Zovirax Topical has an overall score of 7. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Zovirax Topical review by 25 year old male patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Shingles |
| Dosage & duration: | | 5% cream (dosage frequency: applied as a cream 3 times a day) for the period of 1 week |
| Other conditions: | | None |
| Other drugs taken: | | Calomine Lotion + Pireteze anti histamine tablets | | |
Reported Results |
| Benefits: | | taken at a stage where puss filled blisters were swollen, ensured a quick and painless transition from this stage to a stage where blisters became dry. Not much effect for 5 days or so, however when the blisters did dry up they did so quickly and was not painful at all which is what i had expected. fairly easy to apply and good consistency for application. |
| Side effects: | | None |
| Comments: | | applied directly onto affected area 3 times a day. chose to apply generously and cover effected area with a bandage. |
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Page last updated: 2009-10-20
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