NEWS HIGHLIGHTSMedia Articles Related to Zonegran (Zonisamide)
Increased Risk Of Seizures Faced By Current Cigarette Smokers
Source: Health News from Medical News Today [2009.11.19]
A recent study determined there is a significant risk of seizure for individuals who currently smoke cigarettes. Boston-based researchers from Brigham and Women's Hospital and Harvard Medical School also found that long-term, moderate intake of caffeine or alcohol does not increase the chance of having a seizure or developing epilepsy.
Improved Understanding Of Why Seizures Occur With Alcohol Withdrawal
Source: Epilepsy News From Medical News Today [2009.10.19]
Epileptic seizures are the most dramatic and prominent aspect of the "alcohol withdrawal syndrome" that occurs when a person abruptly stops a long-term or chronic drinking habit. Researchers have shown that the flow of calcium ions into brain cells via voltage-gated calcium channels plays an important role in the generation of alcohol withdrawal seizures, because blocking this flow suppresses these seizures.
Gene Mutation Linked to Fever-Induced Seizures
Source: MedicineNet Seizure Specialty [2009.09.21]
Title: Gene Mutation Linked to Fever-Induced Seizures
Category: Health News
Created: 9/18/2009 2:10:00 PM
Last Editorial Review: 9/21/2009
Febrile Seizures And Severe Epilepsy In Infants Traced To A Sodium Channel Gene Mutation
Source: Epilepsy News From Medical News Today [2009.09.20]
Mutations in the SCN9A sodium channel gene are a cause of febrile seizures and contribute to a severe form of epilepsy in infants 6 months and younger, report researchers from the University of Utah, University of Antwerp, and University of Washington.
Febrile Seizures
Source: MedicineNet Pediatric Epilepsy Surgery Specialty [2008.05.09]
Title: Febrile Seizures
Category: Diseases and Conditions
Created: 5/9/2008
Last Editorial Review: 5/9/2008
Published Studies Related to Zonegran (Zonisamide)
Zonisamide: in Parkinson's disease. [2009]
Zonisamide, a widely available antiepileptic drug, has been approved in Japan as adjunctive therapy with levodopa for the treatment of previously treated patients with Parkinson's disease. It is an oral 1,2-benzisoxazole-3-methanesulfonamide and is associated with increased striatal dopamine levels in animal models...
Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. [2007.08]
CONCLUSION: In this short-term, open-label, preliminary trial, combination treatment of zonisamide and bupropion resulted in more weight loss than treatment with zonisamide alone.
Zonisamide and renal calculi in patients with epilepsy: how big an issue? [2007.08]
OBJECTIVES: To determine the prevalence of renal calculi in patients treated with zonisamide during randomized, controlled and open-label clinical trials, and from post-marketing surveillance data... CONCLUSIONS: The available data suggest that the risk of developing renal calculi during zonisamide treatment is low. Data are insufficient to determine whether concomitant treatment with topiramate increases the risk of renal stones.
A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor. [2007.02]
Medical therapy for essential tremor (ET), a common movement disorder, is often inadequate... ZNS was effective in reducing tremor amplitude as measured by accelerometry.
A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor. [2007.01.15]
Medical therapy for essential tremor (ET), a common movement disorder, is often inadequate... ZNS was effective in reducing tremor amplitude as measured by accelerometry.
Clinical Trials Related to Zonegran (Zonisamide)
Zonegran for the Treatment of Weight Gain Associated With Psychotropic Medication Use: A Placebo-Controlled Trial [Active, not recruiting]
The primary objective of this study is to compare the efficacy of zonisamide (Zonegran; 100mg
- 400mg/day) and placebo as an adjunctive agent on lowering weight in subjects who have a
body mass index (BMI) of >25 and are on a psychotropic medication with a known side effect of
weight gain.
Fed Study of Zonisamide Capsules 100 mg and Zonegran® Capsules 100 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's zonisamide, 100
mg capsules to Elan's Zonegran® 100 mg capsules following a single, oral 100 mg (1 x 100 mg)
dose administered under fed conditions.
Fasting Study of Zonisamide Capsules 100 mg and Zonegran® Capsules 100 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's zonisamide, 100
mg capsules to Elan's Zonegran® 100 mg capsules following a single, oral 100 mg (1 x 100 mg)
dose administered under fasting conditions.
Open Label, Zonegran (Zonisamide) In Partial Onset Seizures [Completed]
To determine the efficacy and safety of adjunctive open label Zonegran treatment in patients
with refractory partial seizures.
Zonisamide SR Plus Bupropion SR Combination Therapy in Subjects With Obesity [Recruiting]
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