Zonalon (Doxepin Hydrochloride Topical) - Summary

ZONALON SUMMARY

ZONALON^® (doxepin hydrochloride) CREAM, 5%

Zonalon^® (doxepin hydrochloride) Cream, 5% is a topical cream. Each gram contains: 50 mg of doxepin hydrochloride (equivalent to 44.3 mg of doxepin). Doxepin hydrochloride is one of a class of agents known as dibenzoxepin tricyclic antidepressant compounds. It is an isomeric mixture of N,N-dimethyldibenz[ b,e ]oxepin-Δ^11(6H),γ-propylamine hydrochloride.

Zonalon^® Cream is indicated for the short-term (up to 8 days) management of moderate pruritus in adult patients with atopic dermatitis or lichen simplex chronicus. (See DOSAGE AND ADMINISTRATION.)

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ZONALON NEWS HIGHLIGHTS

Published Studies Related to Zonalon (Doxepin Topical)

A randomized controlled clinical trial comparing "guideline exposed" and "guideline naive" physicians in respect to dosage selection and treatment outcome with doxepin in depressive disorders. [2007.03]

Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. [2007]

The sleep-improving effects of doxepin are paralleled by a normalized plasma cortisol secretion in primary insomnia. A placebo-controlled, double-blind, randomized, cross-over study followed by an open treatment over 3 weeks. [2003.12]

Absolute bioavailability and stereoselective pharmacokinetics of doxepin. [2002.07]

Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. [2001.06]

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Clinical Trials Related to Zonalon (Doxepin Topical)

The Treatment of Insomnia in Patients With HIV Disease [Recruiting]

Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism [Recruiting]

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