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Zomig (Zolmitriptan) - Summary

 
 



ZOMIG SUMMARY

ZOMIG®
(zolmitriptan)
TABLETS
ZOMIG-ZMT®
(zolmitriptan)
ORALLY DISINTEGRATING TABLETS

ZOMIG® (zolmitriptan) Tablets and ZOMIG-ZMT® (zolmitriptan) Orally Disintegrating Tablets contain zolmitriptan, which is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist.

ZOMIG is indicated for the acute treatment of migraine with or without aura in adults.

ZOMIG is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of ZOMIG have not been established for cluster headache, which is present in an older, predominantly male population.


See all Zomig indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Zomig (Zolmitriptan)

First-in-class nasal spray demonstrates promise for migraine pain relief
Source: Headache / Migraine News From Medical News Today [2014.11.06]
Researchers are developing a novel prochlorperazine nasal spray formulation as a potential new treatment for migraines.

Differences in nerve structure and function may help to explain how migraine headaches occur
Source: Headache / Migraine News From Medical News Today [2014.11.06]
Migraine linked to defective 'insulation' around nerve fibers, suggests study in Plastic and Reconstructive SurgeryA new study shows cellular-level changes in nerve structure and function that...

Seizures and migraines in the brain linked
Source: Depression News From Medical News Today [2014.11.04]
Seizures and migraines have always been considered separate physiological events in the brain, but now a team of engineers and neuroscientists looking at the brain from a physics viewpoint discovered...

Migraine
Source: MedicineNet Fibromyalgia Specialty [2014.10.20]
Title: Migraine
Category: Diseases and Conditions
Created: 1/31/2014 12:00:00 AM
Last Editorial Review: 10/20/2014 12:00:00 AM

Link found between migraine and Parkinson's
Source: Headache / Migraine News From Medical News Today [2014.09.18]
New research has found there may be an association with migraine in middle age and the development of Parkinson’s disease later in life.

more news >>

Published Studies Related to Zomig (Zolmitriptan)

Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, multicenter, Italian, comparative study versus zolmitriptan. [2011.05]
Menstrually related migraine (MRM) is a particularly difficult-to-treat pain condition, associated with substantial disability. Aim of this study was to compare the efficacy and safety of frovatriptan and zolmitriptan in the treatment of MRM attacks, analyzing data from a multicenter, randomized, double blind, cross-over study...

Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan. [2011.02]
BACKGROUND: Endpoints used to evaluate the efficacy of acute anti-migraine drugs do not measure the tolerability. Sustained pain-free response with no adverse events has been recommended as a composite endpoint which measures the efficacy and tolerability attributes that patients desire... CONCLUSION: Composite efficacy-plus-tolerability endpoints may be useful for facilitating comparisons between treatments.

Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, multicenter, Italian, comparative study versus zolmitriptan. [2011]
Menstrually related migraine (MRM) is a particularly difficult-to-treat pain condition, associated with substantial disability. Aim of this study was to compare the efficacy and safety of frovatriptan and zolmitriptan in the treatment of MRM attacks, analyzing data from a multicenter, randomized, double blind, cross-over study...

Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study. [2010.06]
The objective of this study is to assess patients' satisfaction with migraine treatment with frovatriptan (F) or zolmitriptan (Z), by preference questionnaire. 133 subjects with a history of migraine with or without aura (IHS criteria) were randomized to F 2.5 mg or Z 2.5 mg... In conclusion, our study suggests that F has a similar efficacy of Z, with some advantage as regards tolerability and recurrence.

Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study. [2010]
The objective of this study is to assess patients' satisfaction with migraine treatment with frovatriptan (F) or zolmitriptan (Z), by preference questionnaire. 133 subjects with a history of migraine with or without aura (IHS criteria) were randomized to F 2.5 mg or Z 2.5 mg... In conclusion, our study suggests that F has a similar efficacy of Z, with some advantage as regards tolerability and recurrence.

more studies >>

Clinical Trials Related to Zomig (Zolmitriptan)

ZAP, US. Zomig for Appropriate for Primary Care [Completed]
The purpose of this study is to determine how useful and effective the use of ZOMIG-ZMT™ (zolmitriptan) 5. 0 mg and ZOMIG® Nasal Spray (zolmitriptan) 5. 0 mg is for patients, in treating migraine over a period of 6 months

Determine Central 5-HT1B Receptor Occupancy of ZOMIG® Rapimelt (Zolmitriptan) in Healthy Male Volunteers [Recruiting]

Efficacy of Zolmitriptan (Zomig) in the Treatment of Migraines in Adolescents [Completed]
The purpose of this study is to evaluate the effectiveness and safety of Zolmitriptan (Zomig) nasal spray, 5. 0 mg, compared with placebo (inactive drug) for 2 migraine headaches over a 3-month period in adolescent patients (aged 12 to 17 years) with migraine headaches

Zomig - Treatment of Acute Migraine Headache in Adolescents [Recruiting]
The purpose of this study is to investigate if Zomig® Nasal Spray will help children (age 12-17 years) with migraine headaches feel better. This will be done by comparing 3 different doses of Zomig Nasal Spray with placebo nasal spray (inactive treatment).

Efficacy and Tolerability of Zolmitriptan Nasal Spray [Completed]
The purpose of this study is to evaluate the effectiveness and tolerability (the ability not to experience ill effects from the study drug) of a zolmitriptan nasal spray, 5. 0 mg, compared with placebo (inactive drug) for 2 migraine headaches for up to 12 weeks in adult subjects with migraine headaches

more trials >>

Reports of Suspected Zomig (Zolmitriptan) Side Effects

Migraine (245)Drug Dose Omission (162)Headache (112)Malaise (76)Drug Ineffective (48)Intentional Drug Misuse (42)Vomiting (36)Pain (29)Feeling Abnormal (25)Nausea (18)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 20 ratings/reviews, Zomig has an overall score of 8.20. The effectiveness score is 8.60 and the side effect score is 7.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Zomig review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Migraine
Dosage & duration:   2.5mg taken max x2 per migraine attack for the period of indefinitely
Other conditions:   nausea
Other drugs taken:   domperidone for the nausea
  
Reported Results
Benefits:   allowed me to function rather than having to spend 2-3 days in bed
Side effects:   mild initial discomfort in the neck
Comments:   Prescribed for migraine relief

 

Zomig review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   migraine
Dosage & duration:   2.5 mg rapimelt taken 4x/month on average for the period of 4 years
Other conditions:   hypertension
Other drugs taken:   hydrochlorothiazide 12.5 mg/day
  
Reported Results
Benefits:   Within minutes, migraine disappears 98% of the time. If I wait too long to take medication, it reduces the chances of eliminating the migraine. Without Zomig, I would have a lot of sick days from work.
Side effects:   I feel sleepy but I would rather feel this way than to edure the pain of a migraine.
Comments:   Taken PRN, only prescribed 6 tabs every 20 days

 

Zomig review by care giver of 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Migraine
Dosage & duration:   2.5 ml 2 pills taken once for the period of only once She died same day
Other conditions:   liver problems, diabetes, high blood pressure, lung problems
Other drugs taken:   norco, methodone, blood pressure medicine, plus a few more
  
Reported Results
Benefits:   The medicine did not work on her head ache--she had it all day long.
Side effects:   Sharon complained of severe chest pain from the pills around 8:30 at night. She was also on a lot of other medications and I think the combination of medicines put her into heart attack and she passed away.
Comments:   She took one pill at the Doctors office and she took one home to take. She died some time that night. I think it was too much medication and combination of different medicines. I miss her so much. July 17, 2009

See all Zomig reviews / ratings >>

Page last updated: 2014-11-06

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