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Zolinza (Vorinostat) - Summary

 
 



ZOLINZA SUMMARY

ZOLINZA contains vorinostat, an antineoplastic agent, which is described chemically as N- hydroxy- N'- phenyloctanediamide.

ZOLINZA1 is indicated for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.

ZOLINZA is a histone deacetylase (HDAC) inhibitor indicated for:

  • Treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL) who have progressive, persistent or recurrent disease on or following two systemic therapies. (1)

See all Zolinza indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Zolinza (Vorinostat)

High-tech scans can spare lymphoma patients intensive chemo
Source: Lymphoma / Leukemia / Myeloma News From Medical News Today [2016.06.23]
Hodgkin lymphoma patients can be spared the serious side effects of chemotherapy thanks to high-tech scans that can predict the outcome of treatment, according to a study published in the New...

Scans May Spare Some Hodgkin Lymphoma Patients From Chemo
Source: MedicineNet Cancer Specialty [2016.06.23]
Title: Scans May Spare Some Hodgkin Lymphoma Patients From Chemo
Category: Health News
Created: 6/23/2016 12:00:00 AM
Last Editorial Review: 6/23/2016 12:00:00 AM

After Negative PET, Drop Bleomycin in Hodgkin's Lymphoma
Source: Medscape Hematology-Oncology Headlines [2016.06.22]
After a negative PET scan, patients with advanced Hodgkin's lymphoma can skip bleomycin from the ABVD regimen and still reap clinical benefits with fewer toxicities.
Medscape Medical News

Stem Cell Transplant Can Help HIV Patients Battling Lymphoma: Study
Source: MedicineNet Non-Hodgkins Lymphomas Specialty [2016.06.15]
Title: Stem Cell Transplant Can Help HIV Patients Battling Lymphoma: Study
Category: Health News
Created: 6/15/2016 12:00:00 AM
Last Editorial Review: 6/15/2016 12:00:00 AM

Autologous stem cell transplantation offers safe and effective - and potentially curative - option for patients with HIV-associated lymphoma
Source: HIV / AIDS News From Medical News Today [2016.06.14]
Multicenter, Phase II trial suggests autologous transplant should be standard of care for HIV patients with relapsed/treatment-resistant lymphoma.

more news >>

Published Studies Related to Zolinza (Vorinostat)

A phase I study of vorinostat in combination with idarubicin in relapsed or refractory leukaemia. [2010.07]
Histone deacetylase inhibitors (HDACi) affect chromatin remodelling and modulate the expression of aberrantly silenced genes. HDACi have single-agent clinical activity in haematological malignancies and have synergistic anti-leukaemia activity when combined with anthracyclines in vitro... The combination of vorinostat and idarubicin is generally tolerable and active in patients with advanced leukaemia and should be studied in the front-line setting.

Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. [2010.01.01]
PURPOSE Vorinostat, a histone deacetylase inhibitor, exerts anticancer effects by both histone and nonhistone-mediated mechanisms...

Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. [2010]
PURPOSE Vorinostat, a histone deacetylase inhibitor, exerts anticancer effects by both histone and nonhistone-mediated mechanisms...

A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer. [2009.11.15]
CONCLUSIONS: Administration of a single supratherapeutic dose of the histone deacetylase inhibitor vorinostat is not associated with prolongation of the QTc interval. A dedicated QTc study in advanced cancer patients is a robust means for assessing risk for ventricular repolarization prolongation.

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. [2011.11.12]
Purpose Combining proteasome and histone deacetylase (HDAC) inhibition has been seen to provide synergistic anti-tumor activity, with complementary effects on a number of signaling pathways. The novel bi-cyclic structure of marizomib with its unique proteasome inhibition, toxicology and efficacy profiles, suggested utility in combining it with an HDAC inhibitor such as vorinostat...

more studies >>

Clinical Trials Related to Zolinza (Vorinostat)

Vorinostat Plus FND in Relapsed or Refractory Mantle Cell Lymphoma [Not yet recruiting]
1. Rationale In mantle cell lymphoma, the conventional chemotherapy achieves only temporary responses with a median duration of remissions only from 1 to 2 years. Therefore, mantle cell lymphoma is known as one of the B-cell lymphomas with poor prognosis. Although the treatment outcome of mantle cell lymphoma has been improved since intensive chemotherapy regimens such as HyperCVAD was used, a substantial number of patients are still frequently relapsed after chemotherapy. After relapse, most of them became refractory to various kinds of salvage treatment. That is why the results of most salvage chemotherapy regimens were disappointing. In addition, mantle cell lymphoma generally occurs in elderly people. Thus, intensive salvage chemotherapy may not be feasible for elderly patients. Therefore, an effective, novel combination treatment is urgently needed in relapsed or refractory mantle cell lymphoma patients. 2. Hypothesis

- Vorinostat will produce synergism with a combination treatment regimen

(Fludarabine, mitoxantrone, dexamethasone, FND) without overlapping toxicity

- Vorinostat maintenance treatment will reduce the relapse rate in patients

ineligible for autologous stem cell transplantation. 3. Purpose A phase II investigation to determin the effectiveness of vorinostat in combination with intravenous fludarabine, mitoxantrone, and dexamethasone in patients with relapsed or refractory mantle cell lymphomain patients with relapsed or refractory mantle cell lymphoma.

Study of Suberoylanilide Hydroxamic Acid (SAHA) With Temsirolimus in Children With Diffuse Intrinsic Pontine Glioma (DIPG) [Not yet recruiting]
The goal of this clinical research study is to learn the highest tolerable dose of temsirolimus that can be combined with a stable dose of vorinostat and/or radiation therapy and given to patients with DIPG. The safety of this treatment combination will also be studied.

Study of Vorinostat Plus Capecitabine (X) and Cisplatin (P) for 1st Line Treatment of Metastatic or Recurrent Gastric Cancer [Active, not recruiting]
There is scientific rationale for exploring the role of vorinostat, histone deacetylase inhibitor with capecitabine (X) and cisplatin (P), one of standard chemotherapy in patients with advanced gastric cancer. XP is a new standard of care in advanced gastric cancer (AGC) and vorinostat is a novel targeted agent that prevents tumor cell proliferation, survival and angiogenesis through histone deacetylase inhibition.

Phase 1 Study of Vorinostat and Bortezomib in Multiple Myeloma (MK-0683-015 EXT 1 (AM1)) [Completed]
The purposes of this study are:

- To determine the maximum tolerated dose (MTD) for the combination of oral vorinostat

and bortezomib in participants with advanced multiple myeloma

- To assess the safety and tolerability of this regimen and to document the participant's

clinical status (by anti-tumor activity) for this combination, as determined per standard of care.

MLN9708 and Vorinostat in Patients With Advanced p53 Mutant Malignancies [Recruiting]
The goal of this clinical research study is to find the highest tolerable dose of the combination of MLN9708 and vorinostat that can be given to patients with advanced solid tumors. The safety of these drugs will also be studied.

more trials >>

Reports of Suspected Zolinza (Vorinostat) Side Effects

Pyrexia (15)Decreased Appetite (12)Dehydration (10)Pneumonitis (9)Pleural Effusion (8)Febrile Neutropenia (8)Sepsis (8)Disease Progression (6)White Blood Cell Count Decreased (6)Renal Failure (6)more >>


Page last updated: 2016-06-23

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