Media Articles Related to Zolinza (Vorinostat)
Changes in cancer epigenome implicated in chemotherapy resistance and lymphoma relapse
Source: Genetics News From Medical News Today [2015.04.23]
Genomic studies have illuminated the ways in which malfunctioning genes can drive cancer growth while stunting the therapeutic effects of chemotherapy and other treatments.
Can CT Alone Cure Early-Stage Hodgkin's Lymphoma?
Source: Medscape Hematology-Oncology Headlines [2015.04.22]
Most patients with early-stage Hodgkin's lymphoma will be cured with the current standard of care. However, studies such as RAPID may indicate to some that many patients may be cured with chemotherapy alone.
Medscape Medical News
New assay helps determine lymphoma subtypes simply, quickly, and inexpensively
Source: Lymphoma / Leukemia / Myeloma News From Medical News Today [2015.04.20]
With the advent of targeted lymphoma therapies on the horizon, it becomes increasingly important to differentiate the two major subtypes of diffuse large B-cell lymphoma (DLBCL), which is the most...
Rare, deadly lymphoma demystified
Source: Lymphoma / Leukemia / Myeloma News From Medical News Today [2015.04.17]
Findings identify a cause of the disease and highlight potential therapeutic approachThe first-ever systematic study of the genomes of patients with ALK-negative anaplastic large cell lymphoma...
Central signaling pathway in lymphoma can be blocked successfully
Source: Lymphoma / Leukemia / Myeloma News From Medical News Today [2015.04.10]
Cancer researchers from the University of Zurich have identified a key signaling pathway in B-cell lymphoma, a malignant type of blood cancer.
Published Studies Related to Zolinza (Vorinostat)
A phase I study of vorinostat in combination with idarubicin in relapsed or refractory leukaemia. [2010.07]
Histone deacetylase inhibitors (HDACi) affect chromatin remodelling and modulate the expression of aberrantly silenced genes. HDACi have single-agent clinical activity in haematological malignancies and have synergistic anti-leukaemia activity when combined with anthracyclines in vitro... The combination of vorinostat and idarubicin is generally tolerable and active in patients with advanced leukaemia and should be studied in the front-line setting.
Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. [2010.01.01]
PURPOSE Vorinostat, a histone deacetylase inhibitor, exerts anticancer effects by both histone and nonhistone-mediated mechanisms...
Carboplatin and Paclitaxel in combination with either vorinostat or placebo for
first-line therapy of advanced non-small-cell lung cancer. 
PURPOSE Vorinostat, a histone deacetylase inhibitor, exerts anticancer effects by
both histone and nonhistone-mediated mechanisms...
A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer. [2009.11.15]
CONCLUSIONS: Administration of a single supratherapeutic dose of the histone deacetylase inhibitor vorinostat is not associated with prolongation of the QTc interval. A dedicated QTc study in advanced cancer patients is a robust means for assessing risk for ventricular repolarization prolongation.
Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. [2011.11.12]
Purpose Combining proteasome and histone deacetylase (HDAC) inhibition has been seen to provide synergistic anti-tumor activity, with complementary effects on a number of signaling pathways. The novel bi-cyclic structure of marizomib with its unique proteasome inhibition, toxicology and efficacy profiles, suggested utility in combining it with an HDAC inhibitor such as vorinostat...
Clinical Trials Related to Zolinza (Vorinostat)
SAHA + CHOP in Untreated T-cell Non-Hodgkin's Lymphoma [Recruiting]
The goal of this clinical research study is to find out how well the drug Zolinza
(vorinostat) works in combination with the drug combination called CHOP (cyclophosphamide,
doxorubicin, vincristine, and prednisone) to treat patients with untreated T-cell NHL. The
safety of these drugs in combination and the best dose of vorinostat when given in
combination with CHOP will also be studied.
1. Determine the toxicity profile and the maximum tolerated dose (MTD) of vorinostat when
administered in combination with Cyclophosphamide, Doxorubicin, Vincristine, Prednisone
2. To evaluate the progression free survival for patients with T-cell NHL receiving the
combination of vorinostat and CHOP
Secondary Objectives (Phase I and II):
1. To evaluate the response rate for patients with T-cell NHL receiving the combination of
vorinostat and CHOP.
2. To assess overall survival in patients with T-cell NHL treated with the combination of
vorinostat and CHOP.
Study of Vorinostat Plus Capecitabine (X) and Cisplatin (P) for 1st Line Treatment of Metastatic or Recurrent Gastric Cancer [Recruiting]
There is scientific rationale for exploring the role of vorinostat, histone deacetylase
inhibitor with capecitabine (X) and cisplatin (P), one of standard chemotherapy in patients
with advanced gastric cancer. XP is a new standard of care in advanced gastric cancer (AGC)
and vorinostat is a novel targeted agent that prevents tumor cell proliferation, survival
and angiogenesis through histone deacetylase inhibition.
High-Dose or Low-Dose Vorinostat in Combination With Carboplatin or Paclitaxel in Treating Patients With Advanced Solid Tumors [Recruiting]
This randomized clinical trial is studying high-dose or low-dose vorinostat in combination
with carboplatin or paclitaxel to see how well it works in treating patients with advanced
solid tumors. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work
in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Giving different doses of vorinostat together with carboplatin
or paclitaxel may kill more tumor cells
Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases [Recruiting]
Vorinostat in combination with radiation therapy can be administered safely and will be
tolerated in patients with brain metastases, while providing an assessment of the anti-tumor
activity of this combination.
This is a multi-center, open-label, non-randomized Phase I study in patients with brain
metastases. Patients will be administered oral Vorinostat and radiation therapy and will be
treated for 3 weeks. Patients will be enrolled in cohorts and will be treated at
sequentially rising dose levels of Vorinostat combined with radiation therapy. We will
initially enter 3 subjects at each dose. If none of the three experiences a dose-limiting
toxicity we will proceed to the next dose. If one of the three experiences that level of
toxicity, we will accrue 3 more subjects at that dose. If at any time there are two or more
dose-limiting toxicities (in the 3-6 subjects) on a given dose, we will drop down to a lower
dose. Dose escalation will continue until the MTD of Vorinostat and radiation therapy is
established. The MTD will then be one dose below the DLT occurring in at least 1 out of 3
subjects (2 out of 6 patients).
A Pilot Study of Oral Vorinostat Plus Oral Eltrombopag Support in Patients With Lymphoma (VEIL) [Recruiting]
Vorinostat is a drug (Histone Deacetylase Inhibitor [HDACi]) administered orally that has
been approved in United States for the patients with cutaneous Tcell lymphoma (CTCL) who
have progressive, persistent or recurrent disease on or following two systemic therapies.
In the early period of treatment with vorinostat, some patients may experience low platelet
counts. Therefore this study will be examining the combination of these two medications
(Vorinostat and eltrombopag) to assess if eltrombopag can overcome the low platelets during
treatment with vorinostat.
Eltrombopag is a drug administered orally designed to mimic the protein thrombopoietin,
which causes the body to make more platelets. Eltrombopag has been registered in Australia
and approved overseas to treat patients with chronic ITP (Immune Thrombocytopenia Purpura) a
disease where patients destroy their own platelets very rapidly and thus develop low
platelet count) but it is not registered and it is not yet known whether eltrombopag can
increase platelet counts in patients treated with the HDACi.
The aim of this project is to test whether Vorinostat and eltrombopag can be safely
combined, and to test whether they are effective in participants with T-cell lymphoma
involving the skin or patients with relapsed/refractory follicular lymphoma (FL), marginal
zone lymphoma (MZL), or mantle cell lymphoma (MCL)
A total of 25 people with Cutaneous T cell lymphoma/ CTCL, marginal zone lymphoma,
follicular lymphoma or mantle cell lymphoma will be recruited in this study.
Reports of Suspected Zolinza (Vorinostat) Side Effects
Decreased Appetite (12),
Pleural Effusion (8),
Febrile Neutropenia (8),
Disease Progression (6),
White Blood Cell Count Decreased (6),
Renal Failure (6), more >>