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Zofran (Ondansetron) - Summary

 


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ZOFRAN SUMMARY

The active ingredient in ZOFRAN Tablets and ZOFRAN Oral Solution is ondansetron hydrochloride (HCl) as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT3 receptor type.

  1. Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin >/=50 mg/m2.
  2. Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy.
  3. Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
  4. Prevention of postoperative nausea and/or vomiting. As with other antiemetics, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided postoperatively, ZOFRAN Tablets, ZOFRAN ODT Orally Disintegrating Tablets, and ZOFRAN Oral Solution are recommended even where the incidence of postoperative nausea and/or vomiting is low.


See all Zofran indications & dosage >>

ZOFRAN NEWS HIGHLIGHTS

Published Studies Related to Zofran (Ondansetron)

Added ondansetron for stable schizophrenia: A double blind, placebo controlled trial. [2008.09.11]

Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron. [2008.08.01]

Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study. [2008.08]

Effect of ondansetron on the incidence of vomiting associated with ketamine sedation in children: a double-blind, randomized, placebo-controlled trial. [2008.07]

The role of oral ondansetron in children with vomiting as a result of acute gastritis/gastroenteritis who have failed oral rehydration therapy: a randomized controlled trial. [2008.07]

more >>

Clinical Trials Related to Zofran (Ondansetron)

Bioavailability Study of Ondansetron Orally Disintegrating Tablets Under Fasting Conditions [Completed]

Bioavailability Study of Ondansetron Orally Disintegrating Tablets Under Fed Conditions [Completed]

Bioavailability Study of Ondansetron 24 mg Orally Disintegrating Tablets Under Fasting Conditions [Completed]

Bioavailability Study of Ondansetron 16 mg Orally Disintegrating Tablets Under Fasting Conditions [Completed]

Fasting Study of Ondansetron Tablets 24 mg and ZofranŽ Tablets 24 mg [Completed]

more >>

ZOFRAN PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 2 ratings/reviews, Zofran has an overall score of 6.50. The effectiveness score is 9 and the side effect score is 9. The scores are on ten point scale: 10 - best, 1 - worst.
 

Zofran review by 30 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   nausea
Dosage & duration:   4mg taken 4-6 hours for the period of 2 weeks
Other conditions:   vertigo
Other drugs taken:   meclizine
  
Reported Results
Benefits:   no nausea, able to eat more without getting sick. resoled some of my dizziness
Side effects:   other than dry mouth, none really. I would highly recommend this drug to anyone who experiences vertigo and the nauseaus feeling that comes along with it. PLease ask you doctor to prescribe
Comments:   one pill as needed every 4 hours as needed for nausea and/or vomiting

 

Zofran review by 34 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   nausea
Dosage & duration:   4mg taken 2 times/day for the period of 4 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   no nausea, less vomiting. able to get through work and school feeling better
Side effects:   mild dizziness, sometimes I would get a headache
Comments:   I was prescribes 4 mg zofran to take 4 times per day for relief of nausea and vomiting which was most likely due to vertigo. I had a decrease in the nausea symptoms after the first dose, and had total relief after about 3 doses. i did experience a mile headache, which I believe is common for this drug

See all Zofran reviews / ratings >>

Page last updated: 2008-11-03

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