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Zmax (Azithromycin) - Summary

 
 



ZMAX SUMMARY

Zmax (azithromycin extended release) for oral suspension contains the active ingredient azithromycin (as azithromycin dihydrate), an azalide, a subclass of macrolide antibiotics.

Zmax is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Please see DOSAGE AND ADMINISTRATION for specific dosing recommendations.

Adults

Acute bacterial sinusitis due to Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.

Community-acquired pneumonia due to Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae or Streptococcus pneumoniae, in patients appropriate for oral therapy. (See CLINICAL STUDIES.)

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Zmax and other antibacterial drugs, Zmax should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Appropriate culture and susceptibility tests should be performed before treatment to determine the causative organism and its susceptibility to Zmax. Therapy with Zmax may be initiated before results of these tests are known; once the results become available, antimicrobial therapy should be adjusted accordingly.


See all Zmax indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Zmax (Azithromycin)

Expression comparison of azithromycin and clarithromycin in triple-therapy regimens for eradication of Helicobacter pylori in hemodialysis patients. [2014]
To compare a triple-therapy regimen based on change of antibiotic (azithromycin and clarithromycin) for the eradication of Helicobacter pylori in hemodialysis (HD) patients, we studied in a prospective, randomized, double-blinded clinical trial 39 patients who had dyspepsia and showed two positive results from the diagnostic tests of H...

Local drug delivery of 0.5% azithromycin in the treatment of chronic periodontitis among smokers. [2013]
planing (SRP) in the treatment of chronic periodontitis in smokers... CONCLUSIONS: When compared to the placebo, the adjunctive use of 0.5% AZM

Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial. [2013]
BACKGROUND: Bronchiectasis unrelated to cystic fibrosis (CF) is being increasingly recognized in children and adults globally, both in resource-poor and in affluent countries. However, high-quality evidence to inform management is scarce... The first (bronchiectasis exacerbation study; BEST-1) evaluates the efficacy of azithromycin and amoxycillin-clavulanate compared with placebo, and the second RCT (BEST-2), described here, is designed to determine if azithromycin is non-inferior to amoxycillin-clavulanate in achieving symptom resolution by day 21 of treatment in children with acute respiratory exacerbations.

Development, in vitro and in vivo evaluation of novel injectable smart gels of azithromycin for chronic periodontitis. [2013]
Periodontitis is an inflammatory condition affecting teeth resulting in progressive destruction of periodontal ligaments, resorption of alveolar bone and loss of teeth...

Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial. [2012]
bronchiectasis... INTERPRETATION: Azithromycin is a new option for prevention of exacerbations in

more studies >>

Clinical Trials Related to Zmax (Azithromycin)

A Randomized, Open Label, Clinical Trial of the Pharmacokinetics of Azithromycin Following a Single Dose of Azithromycin Sustained Release (2 Gram) or Commercial Azithromycin Tablet (500 mg) to Cancer Patients That Require Lung Surgery [Completed]
The objective of this trial was to characterize the pharmacokinetics of the currently marketed azithromycin immediate release tablet formulation (AZ-IR) versus the azithromycin sustained release liquid formulation (AZ-SR) in lung tissue and bronchial washings, the latter consisting of the epithelial lining fluid (ELF) and cellular elements, mainly alveolar macrophages (AM).

A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin Sustained Release Versus 3-Day Azithromycin for the Treatment of Strep Throat in Adolescents and Adults [Completed]
To determine if a single 2. 0-g dose of azithromycin SR is at least as effective as a 3-day course of azithromycin (500 mg once daily for 3 days) when used to treat adolescents and adults with strep throat, and to assess efficacy and safety for both treatment regimens.

Comparative Study of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone to Treat Subjects With Blepharoconjunctivitis [Not yet recruiting]

Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis [Not yet recruiting]
This study will assess the superior protective immunity of the combination of chloroquine and azithromycin prophylaxis under Chemoprophylaxis Sporozoites (CPS) immunization versus a standard chloroquine prophylactic regimen.

Zithromax EV in Community-Acquired Pneumonia (CAP) [Completed]
The intravenous (IV) regimen containing azithromycin (Zithromax) plus ampicillin-sulbactam is consistent with current guidelines for the treatment of CAP. In fact the International guidelines for the treatment of CAP in hospitalised patients suggests the use of a combination between a b-lactam and a macrolide.

This trial will allow investigators to evaluate the efficacy of azithromycin plus ampicillin-sulbactam in the treatment of hospitalized subjects with community acquired pneumonia. In addition, this trial will allow investigators to evaluate the safety and toleration of combination therapy.

more trials >>

Reports of Suspected Zmax (Azithromycin) Side Effects

Diarrhoea (5)Abdominal Pain Upper (2)Dizziness (2)Crying (2)Nervousness (2)Vomiting (2)Nausea (2)Tinnitus (1)Drug Ineffective (1)Deafness (1)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 8 ratings/reviews, Zmax has an overall score of 7.25. The effectiveness score is 8.75 and the side effect score is 7.75. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Zmax review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   cold / flu
Dosage & duration:   250mg taken once per day for 5 days for the period of 5 days
Other conditions:   fever, chills, runny nose
Other drugs taken:   none
  
Reported Results
Benefits:   Quick relief of flu-like symptoms
Side effects:   I have never had any side effects from this medication. My husband and 13 year old daughter also take this without any side effects.
Comments:   The first day, you take 2 pills and then for the next four days you take 1 pill. The packaging is excellent and tells you exactly what pills to take and when to take them. As previously stated, no one in my family has experienced any side effects from taking this medication. We have taken both the Z-pak and the generic form. It works incredibly fast and has saved us from many vacation disasters!

 

Zmax review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   bronchitis
Dosage & duration:   250 mg. taken once a day for the period of 5 days
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The medicine kept the illness from getting worse, my cough loosened up immediately. The dose and length of treatment was very managable, it was easy to remember to take one dose each day. The packaging is very convenient - a blister pack so you know immediately how many you have taken.
Side effects:   I experienced some mild stomach upset a few hours after taking the first dose (a combined dose totalling 500 mg.)
Comments:   6 pills taken over 5 days - 2 pills first day, one each day after.

 

Zmax review by 32 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Strep throat
Dosage & duration:   250 mg- 2 pills day 1 then 1 pill/day taken 2 pills on day 1 for the period of 2 pills on day 1 only
Other conditions:   n/a
Other drugs taken:   none
  
Reported Results
Benefits:   Antibiotic seemed to work quickly. My throat felt better within hours of taking the first pill.
Side effects:   Horrible, painful diarrhea after 4 hours of taking each pill I took on day one.
Comments:   Seems like a powerful antibiotic that works but it's just too powerful for my system and not worth the side effect.

See all Zmax reviews / ratings >>

Page last updated: 2014-11-30

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