ZIANA SUMMARY
ZIANA (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, is an antibiotic and retinoid combination gel product with two active ingredients. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.
ZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older.
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NEWS HIGHLIGHTSMedia Articles Related to Ziana (Clindamycin / Tretinoin Topical)
EMA: Benefits Outweigh VTE Risks With Hormone Drugs for Acne
Source: Medscape Medical News Headlines [2013.05.17]
The EMA has issued a recommendation that the benefits of the hormonal acne treatment Diane and its generics outweigh the risks, provided that several measures are taken to minimize the risk of thromboembolism.
International Approvals
Research Letter Suggests Twitter May Serve As A Good Forum For Communicating Information About Acne
Source: Health News from Medical News Today [2013.05.17]
JAMA Dermatology Study Highlights A research letter by Kamal Jethwani, M.D., M.P.H., of the Center for Connected Health, Boston, and colleagues suggests that clinicians can learn about the perceptions and misconceptions of diseases like acne via Twitter, and communicate reliable medical information on the popular social media platform...
Pediatricians Endorse New Acne Treatment Guidelines
Source: MedicineNet Acne Specialty [2013.05.06]
Title: Pediatricians Endorse New Acne Treatment Guidelines
Category: Health News
Created: 5/6/2013 10:35:00 AM
Last Editorial Review: 5/6/2013 12:00:00 AM
Tx for Pediatric Acne Gets New Guidance (CME/CE)
Source: MedPage Today Dermatology [2013.05.04]
(MedPage Today) -- Typically seen as a teenager's disease, acne also presents in children and infants, and treatments should be age appropriate, according to new recommendations from the American Acne and Rosacea Society.
With Acne, Bacteria Strain on Your Skin May Be Culprit
Source: MedicineNet Acne Specialty [2013.02.28]
Title: With Acne, Bacteria Strain on Your Skin May Be Culprit
Category: Health News
Created: 2/28/2013 10:35:00 AM
Last Editorial Review: 2/28/2013 12:00:00 AM
Published Studies Related to Ziana (Clindamycin / Tretinoin Topical)
Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. [2009.04]
CONCLUSION: CLIN/RA was significantly better tolerated than was 0.1% tretinoin gel, as evidenced by significantly reduced erythema (P < 0.04), scaling (P < 0.03), itching (P < 0.02), burning (P < 0.03) and stinging (P < 0.04). A trend for greater erythema, scaling, and subjective discomfort for 0.1% adapalene gel compared to CLIN/RA was also evident.
Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris. [2007.06]
Clindamycin phosphate 1.2% and tretinoin 0.025% gel (CLIN/RA gel [ZIANA Gel]) is a novel topical combination agent approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. A solution of clindamycin phosphate 1.2% combined with partially solubilized and crystalline tretinoin 0.025% suspended in an aqueous-based, alcohol-free gel formulation, CLIN/RA gel was studied in 2 randomized, vehicle-controlled trials involving more than 4,500 patients...
Clinical Trials Related to Ziana (Clindamycin / Tretinoin Topical)
Combination Treatment for Moderate to Severe Acne [Not yet recruiting]
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Ziana has an overall score of 6.67. The effectiveness score is 6.67 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Ziana review by 40 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | Apply once a day (dosage frequency: daily) for the period of Ongoing |
| Other conditions: | | Hyperpigmentation |
| Other drugs taken: | | Hydroquinone Cream | | |
Reported Results |
| Benefits: | | Easy to apply, combination of retinol and antibiotic. Treated acne and an anti-aging treatment too. The gel is odorless and goes on easily. It is also non-greasy which is important if you have combination or oily skin. |
| Side effects: | | Dry, peeling skin. Skin was more sensitive for a short time. Also need to wear a high SPF daily for skin protection. |
| Comments: | | Apply once a day at night on dry skin. |
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| | Ziana review by 39 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne / blackheads / oily skin |
| Dosage & duration: | | 0.025% (dosage frequency: once daily / night time) for the period of 6 weeks |
| Other conditions: | | n/a |
| Other drugs taken: | | oral birth control | | |
Reported Results |
| Benefits: | | Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this. |
| Side effects: | | Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face. |
| Comments: | | I would apply the Ziana once a day at night after washing my face with a mild cleanser. |
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| | Ziana review by 39 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne / blackheads / oily skin |
| Dosage & duration: | | 0.025% (dosage frequency: once daily / night time) for the period of 6 weeks |
| Other conditions: | | n/a |
| Other drugs taken: | | oral birth control | | |
Reported Results |
| Benefits: | | Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this. |
| Side effects: | | Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face. |
| Comments: | | I would apply the Ziana once a day at night after washing my face with a mild cleanser. |
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Page last updated: 2013-05-17
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