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Ziana (Clindamycin Phosphate / Tretinoin Topical) - Summary

 
 



ZIANA SUMMARY

ZIANA (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, is an antibiotic and retinoid combination gel product with two active ingredients. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

ZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older.


See all Ziana indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ziana (Clindamycin / Tretinoin Topical)

Acne App Takes Telemedicine to New Level
Source: MedPage Today Dermatology [2014.07.16]
(MedPage Today) -- Take a selfie, fill out a form, get a prescription. Is this the future of dermatology?

Some acne products can cause serious allergic reactions, FDA warns
Source: Dermatology News From Medical News Today [2014.06.27]
Over the counter skin products for acne that contain benzoyl peroxide or salicylic acid can cause rare but serious and potentially life-threatening reactions, say FDA.

Some Acne Products Can Trigger Severe Allergic Reactions: FDA
Source: MedicineNet Acne Specialty [2014.06.26]
Title: Some Acne Products Can Trigger Severe Allergic Reactions: FDA
Category: Health News
Created: 6/25/2014 4:35:00 PM
Last Editorial Review: 6/26/2014 12:00:00 AM

New Approaches to Acne Treatment
Source: MedicineNet Acne Specialty [2014.06.10]
Title: New Approaches to Acne Treatment
Category: Health News
Created: 6/9/2014 12:35:00 PM
Last Editorial Review: 6/10/2014 12:00:00 AM

Health Tip: Caring for Acne-Prone Skin
Source: MedicineNet Acne Specialty [2014.05.29]
Title: Health Tip: Caring for Acne-Prone Skin
Category: Health News
Created: 5/29/2014 7:35:00 AM
Last Editorial Review: 5/29/2014 12:00:00 AM

more news >>

Published Studies Related to Ziana (Clindamycin / Tretinoin Topical)

Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. [2009.04]
CONCLUSION: CLIN/RA was significantly better tolerated than was 0.1% tretinoin gel, as evidenced by significantly reduced erythema (P < 0.04), scaling (P < 0.03), itching (P < 0.02), burning (P < 0.03) and stinging (P < 0.04). A trend for greater erythema, scaling, and subjective discomfort for 0.1% adapalene gel compared to CLIN/RA was also evident.

Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris. [2007.06]
Clindamycin phosphate 1.2% and tretinoin 0.025% gel (CLIN/RA gel [ZIANA Gel]) is a novel topical combination agent approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. A solution of clindamycin phosphate 1.2% combined with partially solubilized and crystalline tretinoin 0.025% suspended in an aqueous-based, alcohol-free gel formulation, CLIN/RA gel was studied in 2 randomized, vehicle-controlled trials involving more than 4,500 patients...

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Clinical Trials Related to Ziana (Clindamycin / Tretinoin Topical)

Combination Treatment for Moderate to Severe Acne [Not yet recruiting]

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Ziana has an overall score of 6.67. The effectiveness score is 6.67 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Ziana review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   Apply once a day (dosage frequency: daily) for the period of Ongoing
Other conditions:   Hyperpigmentation
Other drugs taken:   Hydroquinone Cream
  
Reported Results
Benefits:   Easy to apply, combination of retinol and antibiotic. Treated acne and an anti-aging treatment too. The gel is odorless and goes on easily. It is also non-greasy which is important if you have combination or oily skin.
Side effects:   Dry, peeling skin. Skin was more sensitive for a short time. Also need to wear a high SPF daily for skin protection.
Comments:   Apply once a day at night on dry skin.

 

Ziana review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne / blackheads / oily skin
Dosage & duration:   0.025% (dosage frequency: once daily / night time) for the period of 6 weeks
Other conditions:   n/a
Other drugs taken:   oral birth control
  
Reported Results
Benefits:   Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this.
Side effects:   Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face.
Comments:   I would apply the Ziana once a day at night after washing my face with a mild cleanser.

 

Ziana review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne / blackheads / oily skin
Dosage & duration:   0.025% (dosage frequency: once daily / night time) for the period of 6 weeks
Other conditions:   n/a
Other drugs taken:   oral birth control
  
Reported Results
Benefits:   Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this.
Side effects:   Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face.
Comments:   I would apply the Ziana once a day at night after washing my face with a mild cleanser.

See all Ziana reviews / ratings >>

Page last updated: 2014-07-16

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