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Ziana (Clindamycin Phosphate / Tretinoin Topical) - Summary

 
 



ZIANA SUMMARY

ZIANA (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, is an antibiotic and retinoid combination gel product with two active ingredients. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

ZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older.


See all Ziana indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ziana (Clindamycin / Tretinoin Topical)

Health Tip: Four Common Types Of Acne
Source: MedicineNet Acne Specialty [2017.09.20]
Title: Health Tip: Four Common Types Of Acne
Category: Health News
Created: 9/20/2017 12:00:00 AM
Last Editorial Review: 9/20/2017 12:00:00 AM

Acne (Pimples) Quiz: Test Your Medical IQ
Source: MedicineNet Acne Specialty [2017.09.19]
Title: Acne (Pimples) Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 2/28/2011 4:15:00 PM
Last Editorial Review: 9/19/2017 5:39:39 PM

Skin Quiz: Acne, Dry Skin, Dandruff & More
Source: MedicineNet Acne Specialty [2017.09.19]
Title: Skin Quiz: Acne, Dry Skin, Dandruff & More
Category: MedicineNet Quiz
Created: 10/7/2010 12:00:00 AM
Last Editorial Review: 9/19/2017 5:01:04 PM

Health Tip: Can't Clear Your Acne?
Source: MedicineNet Acne Specialty [2017.08.02]
Title: Health Tip: Can't Clear Your Acne?
Category: Health News
Created: 8/2/2017 12:00:00 AM
Last Editorial Review: 8/2/2017 12:00:00 AM

Acne 101: Types, Best Treatments, Medication, Cystic Acne
Source: MedicineNet isotretinoin Specialty [2017.05.04]
Title: Acne 101: Types, Best Treatments, Medication, Cystic Acne
Category: Slideshows
Created: 10/16/2014 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM

more news >>

Published Studies Related to Ziana (Clindamycin / Tretinoin Topical)

Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. [2009.04]
CONCLUSION: CLIN/RA was significantly better tolerated than was 0.1% tretinoin gel, as evidenced by significantly reduced erythema (P < 0.04), scaling (P < 0.03), itching (P < 0.02), burning (P < 0.03) and stinging (P < 0.04). A trend for greater erythema, scaling, and subjective discomfort for 0.1% adapalene gel compared to CLIN/RA was also evident.

Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris. [2007.06]
Clindamycin phosphate 1.2% and tretinoin 0.025% gel (CLIN/RA gel [ZIANA Gel]) is a novel topical combination agent approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. A solution of clindamycin phosphate 1.2% combined with partially solubilized and crystalline tretinoin 0.025% suspended in an aqueous-based, alcohol-free gel formulation, CLIN/RA gel was studied in 2 randomized, vehicle-controlled trials involving more than 4,500 patients...

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Clinical Trials Related to Ziana (Clindamycin / Tretinoin Topical)

Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and Placebo [Completed]

Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris [Completed]
The purpose of this research study is to evaluate the effectiveness of two different types of topical acne medication. This study will help to determine if one combined medication results in better acne improvement than two separate medications for acne.

Combination Treatment for Moderate to Severe Acne [Completed]

Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne [Completed]
The purpose of the study is to determine the development of microbial resistance when using one of two topical acne therapies for the treatment of facial acne vulgaris.

Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea [Completed]
The purpose of this study is to determine whether Clindamycin Phosphate 1. 2% And Tretinoin 0. 025% Gel are effective and safe in the treatment of papulopustular rosacea.

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Ziana has an overall score of 6.67. The effectiveness score is 6.67 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Ziana review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   Apply once a day (dosage frequency: daily) for the period of Ongoing
Other conditions:   Hyperpigmentation
Other drugs taken:   Hydroquinone Cream
  
Reported Results
Benefits:   Easy to apply, combination of retinol and antibiotic. Treated acne and an anti-aging treatment too. The gel is odorless and goes on easily. It is also non-greasy which is important if you have combination or oily skin.
Side effects:   Dry, peeling skin. Skin was more sensitive for a short time. Also need to wear a high SPF daily for skin protection.
Comments:   Apply once a day at night on dry skin.

 

Ziana review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne / blackheads / oily skin
Dosage & duration:   0.025% (dosage frequency: once daily / night time) for the period of 6 weeks
Other conditions:   n/a
Other drugs taken:   oral birth control
  
Reported Results
Benefits:   Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this.
Side effects:   Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face.
Comments:   I would apply the Ziana once a day at night after washing my face with a mild cleanser.

 

Ziana review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne / blackheads / oily skin
Dosage & duration:   0.025% (dosage frequency: once daily / night time) for the period of 6 weeks
Other conditions:   n/a
Other drugs taken:   oral birth control
  
Reported Results
Benefits:   Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this.
Side effects:   Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face.
Comments:   I would apply the Ziana once a day at night after washing my face with a mild cleanser.

See all Ziana reviews / ratings >>

Page last updated: 2017-09-20

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