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Ziana (Clindamycin Phosphate / Tretinoin Topical) - Summary

 
 



ZIANA SUMMARY

ZIANA (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, is an antibiotic and retinoid combination gel product with two active ingredients. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

ZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older.


See all Ziana indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ziana (Clindamycin / Tretinoin Topical)

Efficacy of topical benzoyl peroxide on the reduction of propionibacterium acnes during shoulder surgery
Source: Bones / Orthopedics News From Medical News Today [2015.07.01]
A new paper to be published in The Journal of Shoulder and Elbow Surgery evaluates the effect that topical benzoyl peroxide (BPO), with chlorhexidine skin preparation, has on the presence of...

Acne Pictures Slideshow: Quick Cover-ups, Do's and Don'ts
Source: MedicineNet Acne Specialty [2015.06.26]
Title: Acne Pictures Slideshow: Quick Cover-ups, Do's and Don'ts
Category: Slideshows
Created: 8/1/2012 12:00:00 AM
Last Editorial Review: 6/26/2015 12:00:00 AM

Got acne? Lay off the B12
Source: Dermatology News From Medical News Today [2015.06.25]
Vitamin B12 tweaks how genes behave in the facial bacteria of some people who normally enjoy clear skin. The activity changes of the facial bacteria promote inflammation and lead to pimples.

Could a Vitamin Play a Role in Acne Outbreaks?
Source: MedicineNet Acne Specialty [2015.06.25]
Title: Could a Vitamin Play a Role in Acne Outbreaks?
Category: Health News
Created: 6/24/2015 12:00:00 AM
Last Editorial Review: 6/25/2015 12:00:00 AM

Acne patients: 'substantial proportion' fail to collect prescribed treatment
Source: Compliance News From Medical News Today [2015.03.22]
Dermatologist-prescribed treatments are being left on pharmacy shelves by up to a quarter of people with acne, according to a new study.

more news >>

Published Studies Related to Ziana (Clindamycin / Tretinoin Topical)

Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. [2009.04]
CONCLUSION: CLIN/RA was significantly better tolerated than was 0.1% tretinoin gel, as evidenced by significantly reduced erythema (P < 0.04), scaling (P < 0.03), itching (P < 0.02), burning (P < 0.03) and stinging (P < 0.04). A trend for greater erythema, scaling, and subjective discomfort for 0.1% adapalene gel compared to CLIN/RA was also evident.

Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris. [2007.06]
Clindamycin phosphate 1.2% and tretinoin 0.025% gel (CLIN/RA gel [ZIANA Gel]) is a novel topical combination agent approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. A solution of clindamycin phosphate 1.2% combined with partially solubilized and crystalline tretinoin 0.025% suspended in an aqueous-based, alcohol-free gel formulation, CLIN/RA gel was studied in 2 randomized, vehicle-controlled trials involving more than 4,500 patients...

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Clinical Trials Related to Ziana (Clindamycin / Tretinoin Topical)

Combination Treatment for Moderate to Severe Acne [Not yet recruiting]

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Ziana has an overall score of 6.67. The effectiveness score is 6.67 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Ziana review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   Apply once a day (dosage frequency: daily) for the period of Ongoing
Other conditions:   Hyperpigmentation
Other drugs taken:   Hydroquinone Cream
  
Reported Results
Benefits:   Easy to apply, combination of retinol and antibiotic. Treated acne and an anti-aging treatment too. The gel is odorless and goes on easily. It is also non-greasy which is important if you have combination or oily skin.
Side effects:   Dry, peeling skin. Skin was more sensitive for a short time. Also need to wear a high SPF daily for skin protection.
Comments:   Apply once a day at night on dry skin.

 

Ziana review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne / blackheads / oily skin
Dosage & duration:   0.025% (dosage frequency: once daily / night time) for the period of 6 weeks
Other conditions:   n/a
Other drugs taken:   oral birth control
  
Reported Results
Benefits:   Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this.
Side effects:   Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face.
Comments:   I would apply the Ziana once a day at night after washing my face with a mild cleanser.

 

Ziana review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne / blackheads / oily skin
Dosage & duration:   0.025% (dosage frequency: once daily / night time) for the period of 6 weeks
Other conditions:   n/a
Other drugs taken:   oral birth control
  
Reported Results
Benefits:   Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this.
Side effects:   Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face.
Comments:   I would apply the Ziana once a day at night after washing my face with a mild cleanser.

See all Ziana reviews / ratings >>

Page last updated: 2015-07-01

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