ZIANA SUMMARY
ZIANA (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, is an antibiotic and retinoid combination gel product with two active ingredients. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.
ZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older.
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NEWS HIGHLIGHTSMedia Articles Related to Ziana (Clindamycin / Tretinoin Topical)
Health Tip: What's Triggering My Acne?
Source: MedicineNet Acne Specialty [2009.06.24]
Title: Health Tip: What's Triggering My Acne?
Category: Health News
Created: 6/24/2009 7:00:00 AM
Last Editorial Review: 6/24/2009
New Laser Combo Therapy Zaps Acne
Source: MedicineNet Acne Specialty [2009.03.09]
Title: New Laser Combo Therapy Zaps Acne
Category: Health News
Created: 3/7/2009 2:00:00 AM
Last Editorial Review: 3/9/2009
Acne Cream Not Linked to Raised Death Risk
Source: MedicineNet tretinoin Specialty [2009.01.26]
Title: Acne Cream Not Linked to Raised Death Risk
Category: Health News
Created: 1/24/2009 2:00:00 AM
Last Editorial Review: 1/26/2009
FDA OKs New Acne Gel Epiduo
Source: MedicineNet adapalene Specialty [2009.01.07]
Title: FDA OKs New Acne Gel Epiduo
Category: Health News
Created: 1/7/2009
Last Editorial Review: 1/7/2009
Acne (Pimples)
Source: MedicineNet Boils Specialty [2008.07.16]
Title: Acne (Pimples)
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 7/16/2008
Published Studies Related to Ziana (Clindamycin / Tretinoin Topical)
Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. [2009.04]
CONCLUSION: CLIN/RA was significantly better tolerated than was 0.1% tretinoin gel, as evidenced by significantly reduced erythema (P < 0.04), scaling (P < 0.03), itching (P < 0.02), burning (P < 0.03) and stinging (P < 0.04). A trend for greater erythema, scaling, and subjective discomfort for 0.1% adapalene gel compared to CLIN/RA was also evident.
Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris. [2007.06]
Clindamycin phosphate 1.2% and tretinoin 0.025% gel (CLIN/RA gel [ZIANA Gel]) is a novel topical combination agent approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. A solution of clindamycin phosphate 1.2% combined with partially solubilized and crystalline tretinoin 0.025% suspended in an aqueous-based, alcohol-free gel formulation, CLIN/RA gel was studied in 2 randomized, vehicle-controlled trials involving more than 4,500 patients...
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Ziana has an overall score of 6.67. The effectiveness score is 6.67 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Ziana review by 40 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | Apply once a day (dosage frequency: daily) for the period of Ongoing |
| Other conditions: | | Hyperpigmentation |
| Other drugs taken: | | Hydroquinone Cream | | |
Reported Results |
| Benefits: | | Easy to apply, combination of retinol and antibiotic. Treated acne and an anti-aging treatment too. The gel is odorless and goes on easily. It is also non-greasy which is important if you have combination or oily skin. |
| Side effects: | | Dry, peeling skin. Skin was more sensitive for a short time. Also need to wear a high SPF daily for skin protection. |
| Comments: | | Apply once a day at night on dry skin. |
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| | Ziana review by 39 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne / blackheads / oily skin |
| Dosage & duration: | | 0.025% (dosage frequency: once daily / night time) for the period of 6 weeks |
| Other conditions: | | n/a |
| Other drugs taken: | | oral birth control | | |
Reported Results |
| Benefits: | | Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this. |
| Side effects: | | Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face. |
| Comments: | | I would apply the Ziana once a day at night after washing my face with a mild cleanser. |
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| | Ziana review by 39 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne / blackheads / oily skin |
| Dosage & duration: | | 0.025% (dosage frequency: once daily / night time) for the period of 6 weeks |
| Other conditions: | | n/a |
| Other drugs taken: | | oral birth control | | |
Reported Results |
| Benefits: | | Ziana minimized the large sore pimples. I continued to have a few during my menstrual cycle. However, I continued to experience blocked pores / blackheads and very oily skin. The product did not appear to help this. |
| Side effects: | | Ocassionally I would experience very mild flakey skin. However, given my oily skin it was only noticeable right after I washed my face. |
| Comments: | | I would apply the Ziana once a day at night after washing my face with a mild cleanser. |
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Page last updated: 2009-10-20
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