DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Ziac (Bisoprolol Fumarate / Hydrochlorothiazide) - Summary



ZIAC® (Bisoprolol Fumarate and Hydrochlorothiazide) Tablets

ZIAC (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment of hypertension. It combines two antihypertensive agents in a once-daily dosage: a synthetic beta1-selective (cardioselective) adrenoceptor blocking agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).

ZIAC (bisoprolol fumarate and hydrochlorothiazide) is indicated in the management of hypertension.

See all Ziac indications & dosage >>


Media Articles Related to Ziac (Bisoprolol / Hydrochlorothiazide)

Food container plastics linked to hypertension
Source: Hypertension News From Medical News Today [2015.07.09]
Plastic food containers and wraps containing phthalates were associated with hypertension and insulin resistance in two new studies investigating the chemicals.

Hypertension, high cholesterol, other heart disease risk factors increasing In Asia
Source: Cholesterol News From Medical News Today [2015.07.07]
Research efforts, data collection vital to improved treatmentThe prevalence of cardiovascular risk factors like hypertension, high cholesterol, and diabetes have been decreasing in the United...

Two new studies on the connection between hypertension and cognitive decline
Source: Hypertension News From Medical News Today [2015.07.03]
With the number of individuals affected by cognitive decline expected to rise over the next few decades, investigating its potential causes is of major public health interest.

Portal Hypertension
Source: MedicineNet Cirrhosis Specialty [2015.05.29]
Title: Portal Hypertension
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 5/29/2015 12:00:00 AM

Pulmonary Hypertension
Source: MedicineNet sildenafil Specialty [2015.02.19]
Title: Pulmonary Hypertension
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/19/2015 12:00:00 AM

more news >>

Published Studies Related to Ziac (Bisoprolol / Hydrochlorothiazide)

Screening for eligibility in the study of antihypertensive medication in children: experience from the Ziac Pediatric Hypertension Study. [2001.08]
BACKGROUND: The FDA Modernization Act has resulted in an increase in pediatric trials of antihypertensive medications. As experience is limited in children to guide the planning of these studies, we reviewed data from the Ziac Pediatric Hypertension Study to determine patterns of early study termination to help future studies... CONCLUSIONS: These data suggest that SBP hypertension should be part of inclusion criteria to increase enrollment and reduce the rate of screening termination, and that 1-week placebo screening is necessary and sufficient to minimize inclusion of transiently hypertensive subjects.

Efficacy, safety, and effects on quality of life of bisoprolol/hydrochlorothiazide versus amlodipine in elderly patients with systolic hypertension. [2000.10]
BACKGROUND: Several studies have shown the benefits of antihypertensive treatment in elderly patients in terms of cardiovascular morbidity and mortality rate reduction. Low-dose drug combinations may be of interest in treating older subjects. A randomized, multicenter, double-blind, parallel group study was conducted to compare the efficacy and safety of bisoprolol 2.5 mg/hydrochlorothiazide 6.25 mg (n = 84) to amlodipine 5 mg (n = 80) in isolated systolic hypertension in patients older than 60 years... CONCLUSIONS: This study demonstrates comparable efficacy and tolerability of bisoprolol 2.5 mg/hydrochlorothiazide 6.25 mg and amlodipine 5 mg. The low-dose combination of bisoprolol and hydrochlorothiazide may be an appropriate alternative for elderly patients with systolic hypertension.

Low-dose combination treatment for hypertension versus single-drug treatment-bisoprolol/hydrochlorothiazide versus amlodipine, enalapril, and placebo: combined analysis of comparative studies. [1998.09]
To assess the efficacy and safety of 2.5, 5, and 10 mg bisoprolol/6. 25 mg hydrochlorothiazide (HCTZ), 2.5, 5, and 10 mg amlodipine; and 5, 10, 20, and 40 mg enalapril in subjects (n = 541) with a sitting diastolic blood pressure of 95 to 114 mm Hg, data from two comparative studies were pooled... Lower doses of two drugs in fixed combination can provide as good or better blood pressure control compared with higher doses of a single drug with similar tolerability and safety.

Efficacy of low-dose combination of bisoprolol/hydrochlorothiazide compared with amlodipine and enalapril in men and women with essential hypertension. [1998.06.01]
The efficacy of the low-dose combination of bisoprolol/hydrochlorothiazide was compared with amlodipine and enalapril. The low-dose combination was found to be at least as effective as amlodipine and more effective than enalapril in both men and women..

Low-dose bisoprolol/hydrochlorothiazide: an option in first-line, antihypertensive treatment. [1993.09]
Two recent, multicenter, double-blind, placebo-controlled studies established the efficacy and safety of low-dose bisoprolol/hydrochlorothiazide (HCTZ) in patients with mild to moderate essential hypertension. Bisoprolol, a cardioselective beta-blocker, was used in a dose of 2.5 mg, 5 mg, or 10 mg...

more studies >>

Clinical Trials Related to Ziac (Bisoprolol / Hydrochlorothiazide)

A 12-week, Multicentric Study to Evaluate the Safety and Efficacy of Bisoprolol in Diabetic and Hypertensive Filipinos [Recruiting]
The aim of this 12-week, multicenter, interventional, prospective, open-label and uncontrolled study is to evaluate the safety and efficacy of 5 mg/day and 10 mg/day bisoprolol in hypertensive and diabetic Filipino subjects as monotherapy or as an add-on therapy.

more trials >>

Reports of Suspected Ziac (Bisoprolol / Hydrochlorothiazide) Side Effects

Drug Ineffective (3)Blood Pressure Inadequately Controlled (3)Cerebrovascular Accident (3)Skin Exfoliation (1)Pain (1)Muscle Rigidity (1)Dermatitis Psoriasiform (1)non-Cardiogenic Pulmonary Oedema (1)Conjunctival Hyperaemia (1)Oedema Peripheral (1)more >>


Based on a total of 1 ratings/reviews, Ziac has an overall score of 8. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Ziac review by 51 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   5 mg taken 1/day for the period of 2 years
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   It lowers blood pressure from 100/150 to 85/130 and it also helps eliminate excess fluids which made me very bloated. Now when I wake up in the morning my eyes are not that swollen. Also my heart seems to work without much effort. Before I felt my heart pumping hard and now I can't hardly feel it.
Side effects:   None that I can tell.
Comments:   I take 1 pill of 5 mg every night before going to bed.

See all Ziac reviews / ratings >>

Page last updated: 2015-07-09

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2015