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Zestoretic (Lisinopril / Hydrochlorothiazide) - Summary



When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, ZESTORETIC should be discontinued as soon as possible. See WARNINGS, Pregnancy, Lisinopril, Fetal/Neonatal Morbidity and Mortality.



(lisinopril and hydrochlorothiazide)

ZESTORETIC® (Lisinopril and Hydrochlorothiazide) combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide. Lisinopril, a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor.

ZESTORETIC is indicated for the treatment of hypertension.

These fixed-dose combinations are not indicated for initial therapy (see DOSAGE AND ADMINISTRATION).

In using ZESTORETIC, consideration should be given to the fact that an angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that lisinopril does not have a similar risk. (See WARNINGS.)

In considering the use of ZESTORETIC, it should be noted that ACE inhibitors have been associated with a higher rate of angioedema in black than in nonblack patients (see WARNINGS, Lisinopril).

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Published Studies Related to Zestoretic (Lisinopril / Hydrochlorothiazide)

Effect of telmisartan/hydrochlorothiazide vs lisinopril/hydrochlorothiazide combination on ambulatory blood pressure and cognitive function in elderly hypertensive patients. [2006.03]
The aim of this study was to compare the effects of telmisartan/hydrochlorothiazide (HCTZ) vs lisinopril/HCTZ combination on ambulatory blood pressure and cognitive function in elderly hypertensive patients. A total of 160 patients, 76 men and 84 women, aged 61-75 years, with sitting diastolic blood pressure (DBP)>90 mmHg and <110 mmHg and systolic blood pressure (SBP)>140 mmHg were randomized to receive temisartan 80 mg/HCTZ 12.5 mg o.d...

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Reports of Suspected Zestoretic (Lisinopril / Hydrochlorothiazide) Side Effects

Hypertension (11)Hypokalaemia (8)Transient Ischaemic Attack (8)Headache (7)Hyponatraemia (7)Mental Status Changes (6)Polymedication (6)Cerebrovascular Accident (6)Dysarthria (6)Ear Haemorrhage (5)more >>


Based on a total of 1 ratings/reviews, Zestoretic has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Zestoretic review by 49 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   High blood pressure
Dosage & duration:   20/12.5 x 2 (dosage frequency: once per day) for the period of three years
Other conditions:   None
Other drugs taken:   None
Reported Results
Benefits:   After trying a variety of high blood pressure medicines my doctor prescribed Zestoretic. Zestoretic lowered my blood pressure to acceptable levels of 100/70 from 130/90. The difference between this medicine and prior ones seems to be the diuretic. After experiencing the positive benefits of the diuretic I began watching my sodium intake. I avoid any food that contains 900 or over mgs of sodium per serving. This pretty much eliminates most canned soups, dry packaged side dishes and frozen foods. After 16 months of watching my sodium intake I have become much more sensitive to sodium and no longer use table salt
Side effects:   None
Comments:   I take two tablets once a day at breakfast.

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Page last updated: 2006-11-04

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