Media Articles Related to Zerit (Stavudine)
Four simultaneous interventions could lead to a 62 percent decrease in new HIV infections by 2040
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2014.03.06]
A computer model has created the most effective formula for reducing the spread of HIV among drug users in New York City over the next 25 years.
How sexual contacts with outsiders contribute to HIV infections within communities
Source: HIV / AIDS News From Medical News Today [2014.03.05]
While a number of strategies can prevent and control HIV transmission and spread, their effective use depends on understanding the sexual networks within and between communities. A paper published in PLOS Medicine reports a detailed analysis with surprising results from the Rakai district in Uganda, one of the most studied areas of the HIV/AIDS epidemic in Africa. Mary K.
During pregnancy and the postpartum period women at greater risk of HIV infection
Source: HIV / AIDS News From Medical News Today [2014.02.27]
Women living in world regions where HIV infection is common are at high risk of acquiring HIV infection during pregnancy and the postpartum period, according to a study by US researchers published in this week's PLOS Medicine.
Baby "Cured" of HIV Infection
Source: MedicineNet nevirapine Specialty [2013.04.03]
Title: Baby "Cured" of HIV Infection
Category: Doctor's & Expert's views on Symptoms
Created: 4/3/2013 6:12:00 PM
Last Editorial Review: 4/3/2013 6:12:53 PM
New research on potent HIV antibodies opens up possibilities for HIV prevention and treatment
Source: HIV / AIDS News From Medical News Today [2014.03.05]
The discovery of how a KwaZulu-Natal woman's body responded to her HIV infection by making potent antibodies (called broadly neutralising antibodies, because they are able to kill multiple strains of HIV from across the world), was reported today (3 March 2014) by the CAPRISA consortium of AIDS researchers jointly with scientists from the United States.
Published Studies Related to Zerit (Stavudine)
Pharmacokinetics of generic and trade formulations of lamivudine, stavudine and nevirapine in HIV-infected Malawian children. 
BACKGROUND: The aim of this study was to evaluate the pharmacokinetics of lamivudine (3TC), stavudine (d4T) and nevirapine (NVP) in HIV-infected Malawian children receiving quartered tablet multiples of Triomune 40 (generic tablet [GT]) compared with individual generic liquid (GL) and trade liquid (TL)... CONCLUSIONS: Quartered multiples of Triomune 40 are appropriate for children 18-<22 kg and 28-<32 kg in weight; however, alternative formulations are suggested in children weighing 8-<12 kg.
Changes in body composition with ritonavir-boosted and unboosted atazanavir treatment in combination with Lamivudine and Stavudine: a 96-week randomized, controlled study. [2009.05.01]
This 96-week, open-label, randomized study assessed changes in body composition in treatment-naive patients infected with human immunodeficiency virus type 1 who were treated with either atazanavir or ritonavir-boosted atazanavir, in combination with stavudine and lamivudine.
A single-dose, randomized, open-label, two-period crossover bioequivalence study comparing a fixed-dose pediatric combination of lamivudine and stavudine tablet for oral suspension with individual liquid formulations in healthy adult male volunteers. 
Lamivudine (CAS 134678-17-4) is a synthetic nucleoside analogue with activity against HIV-1 and HBV.
Bioequivalence study of two fixed dose combination tablet formulations of lopinavir and ritonavir in healthy volunteers. 
The study was designed to compare the rate and extent of absorption of two fixed dose combination tablet formulations of lopinavir (CAS 192725-17-0) and ritonavir (CAS 155213-67-5). This bioequivalence study was conducted using a standard preparation as reference and a generic alternative as test in 72 adult healthy volunteers within 18-45 years of age who received a single dose of the test or reference product under fasting conditions...
The influence of lamivudine, stavudine and nevirapine on the pharmacokinetics of chlorpropamide in human subjects. [2008.07]
Diabetic patients tend to be prone to infections, and multiple drug therapy cannot be ruled out in the management of diabetes. The effect of three routinely prescribed antiretroviral (ARV) drugs on the pharmacokinetic profile of an antidiabetic drug, chlorpropamide, was investigated in 18 human subjects, who had recently been diagnosed positive for human immunodeficiency virus (HIV) infection...
Clinical Trials Related to Zerit (Stavudine)
Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY [Active, not recruiting]
Lipodystrophie, peripheral neuropathy and mitochondrial toxicity has been associated to
stavudine at standard doses The aim of this study is to evaluate the efficacy of reduced
doses of stavudine (30 mg b. i.d.) in HIV patients with controlled viral load and body weight
> 60 kg, receiving an antiretroviral therapy containing stavudine 40 mg b. i.d.
Comparison of Stavudine Used Alone or in Combination With Didanosine in HIV-Infected Children [Completed]
To evaluate the safety and determine the pharmacokinetic disposition of stavudine (d4T) alone
and in combination with didanosine (ddI), and whether concurrent administration alters the
disposition of either drug. To compare d4T versus d4T plus ddI with respect to short and long
term changes from baseline in plasma HIV RNA concentrations. To determine the relationship,
if any, between drug exposure and viral burden.
In a pilot study of d4T and ddI given to eight children with advanced HIV for 24 weeks, the
three children with baseline counts greater than 50 cells/micro liter experienced a 20%
increase in their CD4+ lymphocyte counts. Based on these results, controlled trials of the
same regimen for children with less advanced HIV disease should be undertaken.
The Safety and Effectiveness of Nevirapine Plus Nelfinavir in HIV-1 Infected Patients Who Have Taken Stavudine [Completed]
To determine the potential effects of 28 days of nevirapine treatment on the steady-state
pharmacokinetics of nelfinavir and of stavudine (d4T), and to further evaluate the
pharmacokinetics of nevirapine in combination with nelfinavir, and d4T compared to the
historical controls treated with nevirapine but without nelfinavir or d4T. To determine the
efficacy of long-term combination therapy of nevirapine, nelfinavir and d4T on viral load in
patients who are non-nucleoside reverse transcriptase inhibitor (NNRTI) and protease
inhibitor naive, and have <= 6 months prior d4T exposure at the time of screening.
Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment [Active, not recruiting]
The purpose of this study is to see how effective and safe it is to give 1 of the 3 following
treatments to patients who may not have received anti-HIV treatment: 1) lamivudine
(3TC)/abacavir (ABC)/stavudine (d4T); 2) 3TC/ABC/efavirenz (EFV); or 3) 3TC/ABC/amprenavir
A Pilot Study to Compare the Antiviral and Immunologic Effects of Stavudine ( d4T ) Versus Placebo in Subjects With Evidence of Recent HIV Infection. [Completed]
To compare the antiviral effect of stavudine ( d4T ) versus placebo in patients with evidence
of recent HIV infection.
Also, to compare the immunologic effects and effects on quality of life of d4T in these
Reports of Suspected Zerit (Stavudine) Side Effects
Lipodystrophy Acquired (11),
Hepatic Function Abnormal (6),
Immune Reconstitution Syndrome (6),
Platelet Count Decreased (6),
Eczema (5), more >>