Media Articles Related to Zemuron (Rocuronium)
Does Adding Epidural to General Anesthesia Improve Survival in AAA Repair?
Source: Medscape Anesthesiology Headlines [2016.09.19]
Combining epidural and general anesthesia for abdominal aortic aneurysm repair is associated with improved survival and lower risk of complications, according to a recent study. But the associations may not hold up in the real world, other researchers suggest.
Reuters Health Information
Practical Aspects of Using Total Intravenous Anaesthesia
Source: Medscape Anesthesiology Headlines [2016.09.21]
What are the preferred agents for total intravenous anesthesia? For what procedures is it most appropriate? How should it be monitored? Learn the practical approach to TIVA in this article.
Published Studies Related to Zemuron (Rocuronium)
Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial. [2011.08.16]
INTRODUCTION: Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. Concerns relate to the side effects of succinylcholine and to slower onset and inferior intubation conditions associated with rocuronium. So far, succinylcholine and rocuronium have not been compared in an adequately powered randomized trial in intensive care. Accordingly, the aim of the present study was to compare the incidence of hypoxemia after rocuronium or succinylcholine in critically ill patients requiring an emergent RSI... CONCLUSIONS: In critically ill patients undergoing emergent RSI, incidence and severity of oxygen desaturations, the quality of intubation conditions, and incidence of failed intubation attempts did not differ between succinylcholine and rocuronium. TRIAL REGISTRATION: ClinicalTrials.gov, number NCT00355368.
A comparative study between 1 and 2 effective doses of rocuronium for intraoperative neuromonitoring during thyroid surgery. [2011.04]
BACKGROUND: The goal of this study was to explore an ideal application of rocuronium to enable adequate muscle relaxation for intubation without significantly affecting the evoked potentials measured by intraoperative neuromonitoring during thyroid surgery... CONCLUSION: A total of 1 ED(95) of rocuronium (0.3 mg/kg) is an optimal dose for intraoperative neuromonitoring during thyroid surgery. Positive and high EMG signals were obtained in all patients at an early stage of operation, and satisfactory intubating conditions were achieved in most patients. Copyright (c) 2011 Mosby, Inc. All rights reserved.
A randomized trial to identify optimal precurarizing dose of rocuronium to avoid precurarization-induced neuromuscular block. [2011.04]
PURPOSE: The aim of this study was to examine the safe precurarizing dose of rocuronium required to avoid neuromuscular block after precurarization... CONCLUSION: Rocuronium at 0.06 mg/kg is an overdose for precurarization. The results of the present study demonstrate that a safe and effective precurarizing dose of rocuronium is 0.03 mg/kg.
The effect of low dose rocuronium on intraocular pressure in laryngeal mask airway usage. [2011.02]
CONCLUSION: Although there have been reports that LMA insertion minimally increases IOP, in our study, by using low dose rocuronium and LMA there was a decrease in IOP.
Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients. [2011.02]
BACKGROUND: Rapid sequence induction may be associated with hypoxemia. The purpose of this study was to investigate the possible difference in desaturation during rapid sequence induction in overweight patients using either succinylcholine or rocuronium... CONCLUSIONS: Succinylcholine was associated with a significantly more rapid desaturation and longer recovery of oxygen saturation than rocuronium during rapid sequence induction in overweight patients. (c) 2011 The Authors. Journal compilation (c) 2011 The Acta Anaesthesiologica Scandinavica Foundation.
Clinical Trials Related to Zemuron (Rocuronium)
A Study to Compare Different Intubating Doses of Zemuron in Pediatric and Adolescent Subjects Under General Anesthesia [Completed]
The primary purpose of this study is to evaluate the time course of muscle relaxation after
administration of three different single intravenous bolus doses of rocuronium bromide for
intubation (insertion of a tube through the nose or mouth into the trachea to provide
artificial ventilation) in term neonates (birth to <28 days old), infants (28 days to <=3
months) and toddlers (>3 months to <=2 years), children (2 years to less than or equal to 11
years of age), and adolescents (>11 years to less than or equal to 17 years of age).
Subjects in each of the age groups will be randomized to one of 3 Zemuron® doses: 0. 45
mg/kg, 0. 6 mg/kg, or 1. 0 mg/kg.
A Study to Determine the Dose Requirements of Rocuronium Bromide (Zemuron�) in Pediatric and Adolescent Subjects (21048)(COMPLETED)(P05797) [Completed]
The primary purpose of this study is to determine the dose requirements of rocuronium
bromide when administered as a bolus dose (a single, large dose) for intubation (insertion
of a tube through the nose or mouth into the trachea to provide artificial ventilation) and
when administered by either continuous infusion or bolus doses for maintenance of muscle
relaxation in term neonates (birth to <28 days old), infants (28 days to <=3 months) and
toddlers (>3 months to <=2 years), children (2 years to less than or equal to 11 years of
age), and adolescents (>11 years to less than or equal to 17 years of age).
Comparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED) [Completed]
This study was conducted to determine and compare the safety and effectiveness of two
neuromuscular blockers (rocuronium and vecuronium) at various doses in adults who are
undergoing general elective surgery with sevoflurane anesthesia.
Study participants received an intubating dose of a neuromuscular blocker (to enable
insertion of a tube through the nose or mouth into the trachea to provide artificial
ventilation). The intubating dose was followed by repeated bolus maintenance doses as
needed, to maintain muscle relaxation. The time it takes to reach maximal effect of the
neuromuscular blocker (onset time) after the intubating dose was measured and compared as
the primary outcome.
Rocuronium Plus Sugammadex Versus Succinylcholine Alone in Participants Undergoing Short Surgical Procedures (19.4.319)(P05700 AM2)(COMPLETED) [Completed]
A multi-center, randomized, parallel group, comparative, active controlled, safety assessor
blinded trial in adult subjects comparing rocuronium plus sugammadex versus succinylcholine
alone in subjects undergoing short surgical procedures in out-patient surgicenters. The
primary objective was to evaluate changes in plasma potassium levels after treatment with
rocuronium, sugammadex, or succinylcholine in adult subjects scheduled for short surgical
procedures in out-patient surgicenters.
Rocuronium Dose Finding Study After Single-shot or Steady-state Propofol Anesthesia [Completed]
This study is designed to determine the effective-doses ED-50 and ED-95 (the doses required
for a 50% and 95% twitch inhibition, respectively) of the non-depolarizing muscle relaxant
rocuronium after single-shot or steady-state propofol anesthesia in a clinical setting.