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Zemaira (Alpha 1-Antitrypsin) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

ZEMAIRA drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

CONTRAINDICATIONS

Zemaira™ is contraindicated in individuals with a known hypersensitivity to any of its components. Zemaira™ is also contraindicated in individuals with a history of anaphylaxis or severe systemic response to A1-PI products.

Individuals with selective IgA deficiencies who have known antibodies against IgA (anti-IgA antibodies) should not receive Zemaira™, since these patients may experience severe reactions, including anaphylaxis, to IgA that may be present in Zemaira™.

REFERENCES

  1. Stoller JK, Brantly M, et al. Formation and current results of a patient-organized registry for (alpha)1-antitrypsin deficiency. Chest 118(3):843-848, 2000.
  2. McElvaney NG, Stoller JK, et al. Baseline Characteristics of Enrollees in the National Heart, Lung, and Blood Institute Registry of (alpha)1-Antitrypsin Deficiency. Chest 111:394-403, 1997.
  3. Eriksson S. Pulmonary Emphysema and Alpha1-Antitrypsin Deficiency. ACTA Med Scand 175(2):197-205, 1964.
  4. Eriksson S. Studies in (alpha)1-antitrypsin deficiency. ACTA Med Scan Suppl. 432:1-85, 1965.
  5. Morse JO. Alpha1-Antitrypsin Deficiency. N Engl J Med 299:1045-1048; 1099-1105, 1978.
  6. Crystal RG. (alpha)1-Antitrypsin Deficiency, Emphysema, and Liver Disease; Genetic Basis and Strategies for Therapy. J Clin Invest 85:1343-1352, 1990.
  7. World Health Organization. Alpha-1-Antitrypsin Deficiency; Report of a WHO Meeting. Geneva. 18-20 March 1996.
  8. Gadek JE, Crystal RG. (alpha)1-Antitrypsin Deficiency. In: The Metabolic Basis of Inherited Disease 5th ed. Stanbury JB, Wyngaarden JB, Frederickson DS, et al., eds: New York, McGraw-Hill. 1983; pp. 1450-1467.
  9. American Thoracic Society. Guidelines for the Approach to the Patient with Severe Hereditary Alpha-1-Antitrypsin Deficiency. Am Rev Respir Dis 140:1494-1497, 1989.
  10. Gadek JE, Fells GA, Zimmerman RL, Rennard SI, Crystal RG. Antielastases of the Human Alveolar Structures; Implications for the Protease-Antiprotease Theory of Emphysema. J Clin Invest 68:889-898, 1981.

Prolastin® is a registered trademark of Bayer Corporation.

Manufactured by:

Aventis Behring L.L.C.

Kankakee, IL 60901 U.S.A.

U.S. License No. 1281

19131-02

Revised: December 2003

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