Media Articles Related to Zelnorm (Tegaserod)
Rifaximin (Xifaxan) for Irritable Bowel Syndrome (IBS) Treatment
Source: MedicineNet Constipation Specialty [2014.12.01]
Title: Rifaximin (Xifaxan) for Irritable Bowel Syndrome (IBS) Treatment
Category: Doctor's Views
Created: 1/18/2011 12:00:00 AM
Last Editorial Review: 12/1/2014 12:00:00 AM
Pioneering research advances treatment for overactive bladder and irritable bowel syndrome
Source: Irritable-Bowel Syndrome News From Medical News Today [2014.08.24]
Researchers at the University of Surrey have discovered how the receptors responsible for contractions in the bladder, regulate the body's clock genes.
Irritable Bowel Syndrome Triggers and Prevention
Source: MedicineNet Intestinal Gas (Belching, Bloating, Flatulence) Specialty [2014.07.23]
Title: Irritable Bowel Syndrome Triggers and Prevention
Category: Diseases and Conditions
Created: 5/12/2011 12:39:00 PM
Last Editorial Review: 7/23/2014 12:00:00 AM
Irritable Bowel Syndrome (IBS)
Source: MedicineNet alosetron Specialty [2014.02.28]
Title: Irritable Bowel Syndrome (IBS)
Category: Diseases and Conditions
Created: 2/25/2002 12:00:00 AM
Last Editorial Review: 2/28/2014 6:20:35 PM
IBS Pictures Slideshow: Understanding Irritable Bowel Syndrome
Source: MedicineNet Irritable Bowel Syndrome Specialty [2013.11.21]
Title: IBS Pictures Slideshow: Understanding Irritable Bowel Syndrome
Created: 2/12/2010 11:58:00 AM
Last Editorial Review: 11/21/2013 12:00:00 AM
Published Studies Related to Zelnorm (Tegaserod)
Influence of tegaserod on proximal gastric tone and on the perception of gastric distention in functional dyspepsia. [2011.02]
BACKGROUND: Abnormalities in gastric sensorimotor function (hypersensitivity to distention and impaired meal accommodation) have been implicated in the pathophysiology of functional dyspepsia (FD).In the subgroup with normal gastric emptying, tegaserod 6 mg b.i.d enhanced gastric accommodation.
Long-term tegaserod treatment for dysmotility-like functional dyspepsia: results of two identical 1-year cohort studies. [2010.03]
BACKGROUND: Functional dyspepsia (FD) is a chronic disorder that adversely affects health-related quality of life (HRQoL). Published information on its long-term management is minimal and treatment options are limited. AIM: The aim of this study was to evaluate safety, efficacy and HRQoL with tegaserod 6 mg twice daily over 1 year in women with FD who completed one of two 6-week, randomized, placebo-controlled, double-blind studies... CONCLUSIONS: The long-term safety profile of tegaserod in women with FD was consistent with that of short-term treatment and accompanied by improvements in HRQoL, work productivity and symptom relief. These long-term results add to the clinical experience with FD and support the potential value of a 5-HT(4) agonist in the management of FD.
Long-term tegaserod treatment for dysmotility-like functional dyspepsia: results
of two identical 1-year cohort studies. 
6-week, randomized, placebo-controlled, double-blind studies... CONCLUSIONS: The long-term safety profile of tegaserod in women with FD was
A randomized, controlled, double-blind trial of the adjunct use of tegaserod in whole-dose or split-dose polyethylene glycol electrolyte solution for colonoscopy preparation. [2008.08]
BACKGROUND: Problems of compliance, quality, and safety of colon preparation regimens have prompted continued investigation with alternative forms of cleansing. OBJECTIVE: To evaluate the efficacy of tegaserod as an adjunct to a polyethylene glycol electrolyte solution (PEG-E), given as a whole dose or split dose, in colonoscopy preparation... CONCLUSIONS: Tegaserod has a marginal effect on the quality of colonoscopy preparation when used as an adjuvant to PEG-E. The split-dose PEG-E was superior to the whole-dose PEG-E and resulted in better colon cleansing, adherence, and tolerance.
Tegaserod treatment for dysmotility-like functional dyspepsia: results of two randomized, controlled trials. [2008.08]
OBJECTIVES: Therapies for dysmotility-like functional dyspepsia (FD) are limited. We studied tegaserod, a selective serotonin type 4 receptor agonist, in patients with FD... CONCLUSIONS: Some improvement in dysmotility-like FD was observed with tegaserod treatment. The clinical implication of this improvement is uncertain.
Clinical Trials Related to Zelnorm (Tegaserod)
A Treatment Investigational New Drug (tIND) Program of Tegaserod in Women With Irritable Bowel Syndrome With Constipation or With Chronic Idiopathic Constipation [No longer available]
To provide tegaserod to eligible women adult patients who did not have satisfactory
improvement of their irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic
constipation (CIC) symptoms with other available treatment(s) and / or patients who had
satisfactory improvement of their symptoms with prior tegaserod treatment for IBS-C or CIC.
Effect of Tegaserod on Gastric Emptying in Patients With Diabetic Gastroparesis [Terminated]
This study will assess gastric emptying in patients with symptoms of diabetic gastroparesis
treated with tegaserod over 2 weeks.
Safety and Efficacy of Tegaserod in Opioid-Induced Constipation in Patients With Non-Cancer Pain. [Terminated]
This study will evaluate the safety and efficacy of Tegaserod in opioid-induced constipation
(OIC) in patients with non-cancer pain.
Patients who enter this study PRIOR to the core study (CHTF919N2201) interim analysis (IA)
receive the treatment as follows:
Patients on tegaserod 6 mg twice daily (b. i.d.) or 12 mg once daily (o. d.) in the core study
will remain on the same dose in the extension (double-blind).
Patients on placebo during the core study will receive tegaserod 12 mg o. d. (open-label)
Patients who enter this study AFTER the core study interim analysis will receive the selected
tegaserod dose regimen (open-label) determined by the core study IA.
The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia. [Completed]
The Effects of Tegaserod Vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia [Withdrawn]
To demonstrate the effects of tegaserod on gastrointestinal scintigraphic orocecal transit in
female patients with CC and upper GI symptoms of dyspepsia