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Zaroxolyn (Metolazone) - Summary

 


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ZAROXOLYN SUMMARY

ZAROXOLYN Tablets (metolazone tablets, USP) for oral administration contain 2 ½, 5, or 10 mg of metolazone, USP, a diuretic/saluretic/antihypertensive drug of the quinazoline class.

ZAROXOLYN is indicated for the treatment of salt and water retention including:

  • edema accompanying congestive heart failure;
  • edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function.

ZAROXOLYN is also indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class. MYKROX Tablets, a more rapidly available form of metolazone, are intended for the treatment of new patients with mild to moderate hypertension. A dose titration is necessary if MYKROX Tablets are to be substituted for ZAROXOLYN in the treatment of hypertension. See package circular for MYKROX Tablets (Celltech).


See all Zaroxolyn indications & dosage >>

ZAROXOLYN NEWS HIGHLIGHTS

Published Studies Related to Zaroxolyn (Metolazone)

Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. [1997.03]

Addition of metolazone to overcome tolerance to furosemide in infants with bronchopulmonary dysplasia. [1992.06]

The evaluation of the diuretic action of parenteral formulations of metolazone. [2007.01]

Beneficial effects of metolazone in a rat model of preeclampsia. [2006.09]

Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature. [2005.08]

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Clinical Trials Related to Zaroxolyn (Metolazone)

A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients [Recruiting]

Fasting Study of Metolazone Tablets 5 mg and Zaroloxyn® Tablets 5 mg [Completed]

Fasting Study of Metolazone Tablets 10 mg and Zaroloxyn® Tablets 10 mg [Completed]

Fasting Study of Metolazone Tablets 2.5 mg and Zaroloxyn® Tablets 2.5 mg [Completed]

Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension [Completed]

more >>

Page last updated: 2007-05-03

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