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Zarontin (Ethosuximide) - Summary

 
 



ZARONTIN SUMMARY

Zarontin (ethosuximide) is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl-succinimide.

Zarontin is indicated for the control of absence (petit mal) epilepsy.


See all Zarontin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Zarontin (Ethosuximide)

Spotting Psychosis Linked to AEDs in Epilepsy
Source: Medscape Pathology & Lab Medicine Headlines [2016.08.19]
The identification of antiepilepsy drug-induced psychotic disorders among epilepsy patients may become easier after the identification of several associated factors, say Australian researchers.
Medscape Medical News

Factors Flag Psychosis Linked to AEDs in Epilepsy
Source: Medscape NeurologyHeadlines [2016.08.18]
One in seven cases of psychosis among patients with epilepsy is associated with antiepilepsy drugs, a new study suggests. Now, researchers have identified associated factors that may make it easier to spot.
Medscape Medical News

Young People With Epilepsy Struggle on Many Fronts
Source: MedicineNet Seizure Specialty [2016.08.11]
Title: Young People With Epilepsy Struggle on Many Fronts
Category: Health News
Created: 8/10/2016 12:00:00 AM
Last Editorial Review: 8/11/2016 12:00:00 AM

4 Out of 5 Kids With Epilepsy Have Other Health Problems: Study
Source: MedicineNet Birth Defects Specialty [2016.08.01]
Title: 4 Out of 5 Kids With Epilepsy Have Other Health Problems: Study
Category: Health News
Created: 8/1/2016 12:00:00 AM
Last Editorial Review: 8/1/2016 12:00:00 AM

A virtual brain helps decrypt epilepsy
Source: Epilepsy News From Medical News Today [2016.07.29]
Researchers at CNRS, INSERM, Aix-Marseille University and AP-HM have just created a virtual brain that can reconstitute the brain of a person affected by epilepsy for the first time.

more news >>

Published Studies Related to Zarontin (Ethosuximide)

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [2010.03.04]
BACKGROUND: Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.) 2010 Massachusetts Medical Society

Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. [2011.07]
PURPOSE: Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the cortical focus theory...

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. [2010.08]
PURPOSE: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with antiepileptic drug (AED) treatments. The most disturbing issue is the inability of AEDs to provide a persistent cure, because these compounds generally suppress the occurrence of epileptic seizures without necessarily having antiepileptogenic properties...

Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. [2009.07]
Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved...

Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. [2008.11]
The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC)...

more studies >>

Reports of Suspected Zarontin (Ethosuximide) Side Effects

Convulsion (4)Drug Ineffective (3)Poor Quality Drug Administered (3)Atelectasis (2)Pyrexia (2)Mycoplasma Infection (2)Abdominal Discomfort (2)Stevens-Johnson Syndrome (2)Oral Infection (2)Toxic Epidermal Necrolysis (2)more >>


Page last updated: 2016-08-19

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