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Zarontin (Ethosuximide) - Summary

 
 



ZARONTIN SUMMARY

Zarontin (ethosuximide) is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl-succinimide.

Zarontin is indicated for the control of absence (petit mal) epilepsy.


See all Zarontin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Zarontin (Ethosuximide)

A new genetic cause for a progressive form of epilepsy identified
Source: Epilepsy News From Medical News Today [2014.11.19]
An international research consortium has discovered a new gene underlying progressive myoclonus epilepsy, one of the most devastating forms of epilepsy.

Scientists discover new gene for devastating form of epilepsy
Source: Epilepsy News From Medical News Today [2014.11.18]
Scientists have discovered a single mutation in a potassium ion channel gene underlies many unsolved cases of the devastating disorder progressive myoclonus epilepsy.

Epilepsy surgery in childhood can protect memory
Source: Epilepsy News From Medical News Today [2014.11.14]
A type of brain surgery conducted in childhood for medication-resistant epilepsy not only reduces chronic seizures but can protect memory development, a study by a team from Great Ormond Street...

Epilepsy: pooled data from 17 clinical studies support safety of adjunctive Zonegran® (zonisamide) in children aged six and above
Source: Epilepsy News From Medical News Today [2014.11.13]
The safety profile of adjunctive Zonegran® (zonisamide) in paediatric patients with partial epilepsy is confirmed by pooled data published in the European Journal of Paediatric Neurology(EJPN).

Researchers identify new genetic cause of epilepsy
Source: Epilepsy News From Medical News Today [2014.11.10]
San Diego girl improves after discovery of DNA mutation tied to potassium regulationA research team led by scientists at the Scripps Translational Science Institute (STSI) has used whole genome...

more news >>

Published Studies Related to Zarontin (Ethosuximide)

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [2010.03.04]
BACKGROUND: Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.) 2010 Massachusetts Medical Society

Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. [2011.07]
PURPOSE: Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the cortical focus theory...

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. [2010.08]
PURPOSE: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with antiepileptic drug (AED) treatments. The most disturbing issue is the inability of AEDs to provide a persistent cure, because these compounds generally suppress the occurrence of epileptic seizures without necessarily having antiepileptogenic properties...

Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. [2009.07]
Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved...

Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. [2008.11]
The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC)...

more studies >>

Clinical Trials Related to Zarontin (Ethosuximide)

Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS). [Recruiting]
Pain remains the most debilitating symptom for adult patients suffering from complex regional pain syndrome (CRPS). Most CRPS patients gain little to no relief from current painkillers. The purpose of this study is to evaluate the efficacy and safety of ethosuximide in search of much-needed adjunctive therapy to relieve the pain and suffering associated with CRPS.

Chemotherapy Induced Painful Peripheral Neuropathy Ethosuximide (The CIN-E Study) [Recruiting]
This study is a drug trial of ethosuximide as a painkiller if you develop pain as a side effect of chemotherapy. Ethosuximide will be compared against placebo (an inactive substance) to test whether any response is a true effect of the drug, and not a 'placebo effect'.

Comparison of a Drug and Placebo in the Prevention of Migraine Headaches [Not yet recruiting]
The purpose of this study is to determine whether ethosuximide works better than placebo in the prevention of episodic migraine among veterans.

Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study [Active, not recruiting]

Ketogenic Diet vs.Antiepileptic Drug Treatment in Drug Resistant Epilepsy [Recruiting]
This is an open randomized controlled study in children with mental retardation and refractory epilepsy in which treatment with ketogenic diet (KD) is compared with treatment with the antiepileptic drug (AED), not tried by the patient before, which we consider to be the most appropriate AED for the patient.

more trials >>

Reports of Suspected Zarontin (Ethosuximide) Side Effects

Convulsion (4)Drug Ineffective (3)Poor Quality Drug Administered (3)Atelectasis (2)Pyrexia (2)Mycoplasma Infection (2)Abdominal Discomfort (2)Stevens-Johnson Syndrome (2)Oral Infection (2)Toxic Epidermal Necrolysis (2)more >>


Page last updated: 2014-11-19

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