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Zarontin (Ethosuximide) - Summary



Zarontin (ethosuximide) is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl-succinimide.

Zarontin is indicated for the control of absence (petit mal) epilepsy.

See all Zarontin indications & dosage >>


Media Articles Related to Zarontin (Ethosuximide)

EMA Recommends Safety Measures for Levetiracetam in Epilepsy
Source: Medscape NeurologyHeadlines [2016.10.14]
To combat accidental overdose, the EMA advises parents of young patients with epilepsy to only use the dosing syringe that comes with the medication's age-appropriate packaging.
Medscape Medical News

Should video monitors be used to detect night-time seizures in patients with epilepsy?
Source: Epilepsy News From Medical News Today [2016.10.06]
Following a sudden death at a residential care unit, the Dutch Health and Care Inspectorate advised to intensify the use of video monitoring at the unit.

The 'worm' holds the key to treating epilepsy: New possibilities for rapid drug discovery
Source: Epilepsy News From Medical News Today [2016.09.27]
Current methods to control epilepsy are not only inefficient but haven't improved in more than 150 years when the first anticonvulsant drug was developed.

Scientists track down possible new treatment for epilepsy
Source: Epilepsy News From Medical News Today [2016.09.27]
Increasing the concentration of specific fats in the brain could suppress epileptic seizures.

People with epilepsy face increased risks of discrimination and other negative life events
Source: Epilepsy News From Medical News Today [2016.09.20]
In a recent analysis, people with epilepsy were seven-fold more likely to have reported experiencing discrimination due to health problems than the general population.

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Published Studies Related to Zarontin (Ethosuximide)

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [2010.03.04]
BACKGROUND: Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.) 2010 Massachusetts Medical Society

Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. [2011.07]
PURPOSE: Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the cortical focus theory...

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. [2010.08]
PURPOSE: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with antiepileptic drug (AED) treatments. The most disturbing issue is the inability of AEDs to provide a persistent cure, because these compounds generally suppress the occurrence of epileptic seizures without necessarily having antiepileptogenic properties...

Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. [2009.07]
Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved...

Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. [2008.11]
The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC)...

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Reports of Suspected Zarontin (Ethosuximide) Side Effects

Convulsion (4)Drug Ineffective (3)Poor Quality Drug Administered (3)Atelectasis (2)Pyrexia (2)Mycoplasma Infection (2)Abdominal Discomfort (2)Stevens-Johnson Syndrome (2)Oral Infection (2)Toxic Epidermal Necrolysis (2)more >>

Page last updated: 2016-10-14

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