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Zarontin (Ethosuximide) - Summary



Zarontin (ethosuximide) is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl-succinimide.

Zarontin is indicated for the control of absence (petit mal) epilepsy.

See all Zarontin indications & dosage >>


Media Articles Related to Zarontin (Ethosuximide)

Running prevents postnatal side effects of epilepsy drugs in mice
Source: Epilepsy News From Medical News Today [2015.11.20]
The simple act of running may be sufficient to prevent long-term cognitive impairments caused by prenatal exposure to antiepileptic drugs, according to a study published November 19th in Stem Cell...

Brain study sheds light on processes that prompt epilepsy seizures
Source: Epilepsy News From Medical News Today [2015.11.19]
A study of how brain cells communicate with each other when minds are most active could aid research into epilepsy, experts say.

Epilepsy: When the neuron's doorman allows too much in
Source: Epilepsy News From Medical News Today [2015.11.19]
In epilepsy, nerve cells or neurons lose their usual rhythm, and ion channels, which have a decisive influence on their excitability, are involved.

Treating epilepsy and brain traumas by neurotransmitters
Source: Epilepsy News From Medical News Today [2015.11.17]
Roustem Khazipov, Head of the group of researchers from Kazan Federal University and Aix-Marseille University, "Brain activity is based on both excitatory and inhibitory actions regulated by...

Fly method is epilepsy's ray of light
Source: Epilepsy News From Medical News Today [2015.11.06]
Professor Richard Baines and Dr Carlo Giachello used a genetically-altered fruit fly to show that when nervous system activity is suppressed by shining yellow light through its embryo, it will not go...

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Published Studies Related to Zarontin (Ethosuximide)

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [2010.03.04]
BACKGROUND: Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.) 2010 Massachusetts Medical Society

Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. [2011.07]
PURPOSE: Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the cortical focus theory...

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. [2010.08]
PURPOSE: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with antiepileptic drug (AED) treatments. The most disturbing issue is the inability of AEDs to provide a persistent cure, because these compounds generally suppress the occurrence of epileptic seizures without necessarily having antiepileptogenic properties...

Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. [2009.07]
Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved...

Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. [2008.11]
The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC)...

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Reports of Suspected Zarontin (Ethosuximide) Side Effects

Convulsion (4)Drug Ineffective (3)Poor Quality Drug Administered (3)Atelectasis (2)Pyrexia (2)Mycoplasma Infection (2)Abdominal Discomfort (2)Stevens-Johnson Syndrome (2)Oral Infection (2)Toxic Epidermal Necrolysis (2)more >>

Page last updated: 2015-11-20

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