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Zarontin (Ethosuximide) - Summary



Zarontin (ethosuximide) is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl-succinimide.

Zarontin is indicated for the control of absence (petit mal) epilepsy.

See all Zarontin indications & dosage >>


Media Articles Related to Zarontin (Ethosuximide)

Childhood epilepsy not linked with later psychiatric disorders
Source: Epilepsy News From Medical News Today [2015.09.22]
For decades, experts have been studying potential links between childhood epilepsy and various behavioral and psychiatric conditions and some have hypothesized that that they are part of a larger...

Pioneering Epilepsy Passport launches in bid to transform children's epilepsy care, UK
Source: Epilepsy News From Medical News Today [2015.09.17]
Innovative tool developed by Royal College of Paediatrics and Child Health set to improve communication between professionals and keep children and young people out of hospitalWith lack of...

How genetic testing can improve care for children with epilepsy
Source: Epilepsy News From Medical News Today [2015.09.11]
The steps involved in evaluating and diagnosing patients with epilepsy are complicated.

Study results show that once-daily 800mg eslicarbazepine acetate has high retention rates as adjuvant treatment in epilepsy
Source: Epilepsy News From Medical News Today [2015.09.10]
Final results of the non-interventional EPOS (Eslicarbazepine acetate in Partial-Onset Seizure) study, presented at the International Epilepsy Congress (IEC) in Istanbul, show that when once-daily...

Epilepsy: Phase III data confirms efficacy of Fycompa (perampanel)
Source: Epilepsy News From Medical News Today [2015.09.10]
Data at the International Epilepsy Congress in Istanbul show Fycompa® (perampanel) treatment may significantly reduce seizure frequency, both in patients with primary generalised tonic-clonic...

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Published Studies Related to Zarontin (Ethosuximide)

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [2010.03.04]
BACKGROUND: Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.) 2010 Massachusetts Medical Society

Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. [2011.07]
PURPOSE: Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the cortical focus theory...

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. [2010.08]
PURPOSE: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with antiepileptic drug (AED) treatments. The most disturbing issue is the inability of AEDs to provide a persistent cure, because these compounds generally suppress the occurrence of epileptic seizures without necessarily having antiepileptogenic properties...

Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. [2009.07]
Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved...

Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. [2008.11]
The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC)...

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Reports of Suspected Zarontin (Ethosuximide) Side Effects

Convulsion (4)Drug Ineffective (3)Poor Quality Drug Administered (3)Atelectasis (2)Pyrexia (2)Mycoplasma Infection (2)Abdominal Discomfort (2)Stevens-Johnson Syndrome (2)Oral Infection (2)Toxic Epidermal Necrolysis (2)more >>

Page last updated: 2015-09-22

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