Media Articles Related to Zarontin (Ethosuximide)
New technique for testing drugs to treat cystic fibrosis and epilepsy
Source: Health News from Medical News Today [2013.11.30]
Researchers from the University of Southampton, in collaboration with researchers at the University of Quebec at Montreal, have developed a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy.A large percentage of pharmaceutical drugs target ion channels, which are proteins found in a cell's membrane, that play a pivotal role in these serious disorders and that are used to test the effectiveness of new drugs.
A New Once-Daily Epilepsy Pill
Source: Medscape NeurologyHeadlines [2013.11.25]
For now, this new drug is intended for use as adjunctive treatment for partial-onset seizures.
Altered brain connections found in epilepsy patients
Source: Epilepsy News From Medical News Today [2013.11.21]
Patients with the most common form of focal epilepsy have widespread, abnormal connections in their brains that could provide clues toward diagnosis and treatment, according to a new study published online in the journal Radiology.Temporal lobe epilepsy is characterized by seizures emanating from the temporal lobes, which sit on each side of the brain just above the ear.
Scans Show Brain-Connection Differences in Those With Epilepsy
Source: MedicineNet Seizure Specialty [2013.11.19]
Title: Scans Show Brain-Connection Differences in Those With Epilepsy
Category: Health News
Created: 11/19/2013 9:35:00 AM
Last Editorial Review: 11/19/2013 12:00:00 AM
FDA approves medical device to treat epilepsy
Source: Epilepsy News From Medical News Today [2013.11.18]
The U.S. Food and Drug Administration has approved a device to help reduce the frequency of seizures in epilepsy patients who have not responded well to medications.The RNS Stimulator consists of a small neurostimulator implanted within the skull under the scalp.
Published Studies Related to Zarontin (Ethosuximide)
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [2010.03.04]
BACKGROUND: Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.) 2010 Massachusetts Medical Society
Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. [2011.07]
PURPOSE: Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the cortical focus theory...
Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. [2010.08]
PURPOSE: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with antiepileptic drug (AED) treatments. The most disturbing issue is the inability of AEDs to provide a persistent cure, because these compounds generally suppress the occurrence of epileptic seizures without necessarily having antiepileptogenic properties...
Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. [2009.07]
Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved...
Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. [2008.11]
The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC)...
Clinical Trials Related to Zarontin (Ethosuximide)
Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS). [Recruiting]
Pain remains the most debilitating symptom for adult patients suffering from complex
regional pain syndrome (CRPS). Most CRPS patients gain little to no relief from current
painkillers. The purpose of this study is to evaluate the efficacy and safety of
ethosuximide in search of much-needed adjunctive therapy to relieve the pain and suffering
associated with CRPS.
Chemotherapy Induced Painful Peripheral Neuropathy Ethosuximide (The CIN-E Study) [Recruiting]
This study is a drug trial of ethosuximide as a painkiller if you develop pain as a side
effect of chemotherapy. Ethosuximide will be compared against placebo (an inactive
substance) to test whether any response is a true effect of the drug, and not a 'placebo
Comparison of a Drug and Placebo in the Prevention of Migraine Headaches [Not yet recruiting]
The purpose of this study is to determine whether ethosuximide works better than placebo in
the prevention of episodic migraine among veterans.
Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study [Active, not recruiting]
Ketogenic Diet vs.Antiepileptic Drug Treatment in Drug Resistant Epilepsy [Recruiting]
This is an open randomized controlled study in children with mental retardation and
refractory epilepsy in which treatment with ketogenic diet (KD) is compared with treatment
with the antiepileptic drug (AED), not tried by the patient before, which we consider to be
the most appropriate AED for the patient.
Reports of Suspected Zarontin (Ethosuximide) Side Effects
Drug Ineffective (3),
Poor Quality Drug Administered (3),
Mycoplasma Infection (2),
Abdominal Discomfort (2),
Stevens-Johnson Syndrome (2),
Oral Infection (2),
Toxic Epidermal Necrolysis (2), more >>