ADVERSE REACTIONS
The following have been reported as events in clinical trials or in the routine management of patients treated with ZANTAC. The relationship to therapy with ZANTAC has been unclear in many cases. Headache, sometimes severe, seems to be related to administration of ZANTAC.
Central Nervous System
Rarely, malaise, dizziness, somnolence, insomnia, and vertigo. Rare cases of reversible mental confusion, agitation, depression, and hallucinations have been reported, predominantly in severely ill elderly patients. Rare cases of reversible blurred vision suggestive of a change in accommodation have been reported. Rare reports of reversible involuntary motor disturbances have been received.
Cardiovascular
As with other H2-blockers, rare reports of arrhythmias such as tachycardia, bradycardia, atrioventricular block, and premature ventricular beats.
Gastrointestinal
Constipation, diarrhea, nausea/vomiting, abdominal discomfort/pain, and rare reports of pancreatitis.
Hepatic
There have been occasional reports of hepatocellular, cholestatic, or mixed hepatitis, with or without jaundice. In such circumstances, ranitidine should be immediately discontinued. These events are usually reversible, but in rare circumstances death has occurred. Rare cases of hepatic failure have also been reported. In normal volunteers, SGPT values were increased to at least twice the pretreatment levels in 6 of 12 subjects receiving 100 mg q.i.d. intravenously for 7 days, and in 4 of 24 subjects receiving 50 mg q.i.d. intravenously for 5 days.
Musculoskeletal
Rare reports of arthralgias and myalgias.
Hematologic
Blood count changes (leukopenia, granulocytopenia, and thrombocytopenia) have occurred in a few patients. These were usually reversible. Rare cases of agranulocytosis, pancytopenia, sometimes with marrow hypoplasia, and aplastic anemia and exceedingly rare cases of acquired immune hemolytic anemia have been reported.
Endocrine
Controlled studies in animals and man have shown no stimulation of any pituitary hormone by ZANTAC and no antiandrogenic activity, and cimetidine-induced gynecomastia and impotence in hypersecretory patients have resolved when ZANTAC has been substituted. However, occasional cases of gynecomastia, impotence, and loss of libido have been reported in male patients receiving ZANTAC, but the incidence did not differ from that in the general population.
Integumentary
Rash, including rare cases of erythema multiforme. Rare cases of alopecia and vasculitis.
Respiratory
A large epidemiological study suggested an increased risk of developing pneumonia in current users of histamine-2–receptor antagonists (H2RAs) compared to patients who had stopped H2RA treatment, with an observed adjusted relative risk of 1.63 (95% CI, 1.07–2.48). However, a causal relationship between use of H2RAs and pneumonia has not been established.
Other
Rare cases of hypersensitivity reactions (e.g., bronchospasm, fever, rash, eosinophilia), anaphylaxis, angioneurotic edema, acute interstitial nephritis, and small increases in serum creatinine.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO ZANTAC
Below is a sample of reports where side effects / adverse reactions may be related to Zantac. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Zantac side effects / adverse reactions in 58 year old male
Reported by a consumer/non-health professional from France on 2007-01-05
Patient: 58 year old male weighing 78.0 kg (171.6 pounds)
Reactions: Bone Marrow Failure, Bone Marrow Toxicity
Adverse event resulted in: life threatening event
Suspect drug(s):
Zantac
Start date: 2006-09-15
End date: 2006-09-15
Trandate
Start date: 2006-09-07
End date: 2006-09-17
Ciprofloxacin
Dosage: 750mg per day
Indication: Prostatitis
Start date: 2006-08-25
End date: 2006-09-14
Omeprazole
Start date: 2006-07-05
End date: 2006-09-12
Vfend
Start date: 2006-07-27
End date: 2006-09-11
Valganciclovir HCL
Start date: 2006-08-16
End date: 2006-09-11
Possible Zantac side effects / adverse reactions in 28 year old female
Reported by a physician from Viet NAM on 2007-01-05
Patient: 28 year old female weighing 65.0 kg (143.0 pounds)
Reactions: Dyspnoea, Face Oedema, Drug Exposure During Pregnancy, Hypotension, Rash, Laryngeal Oedema
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Zantac
Other drugs received by patient: General Endotracheal Anesthesia
Possible Zantac side effects / adverse reactions in 55 year old female
Reported by a pharmacist from Japan on 2007-01-18
Patient: 55 year old female weighing 57.0 kg (125.4 pounds)
Reactions: Vomiting, Dyspnoea, Hypersensitivity, Loss of Consciousness, Feeling Cold, Malaise, Depressed Level of Consciousness, Blood Pressure Decreased, Cold Sweat
Suspect drug(s):
Zantac
Dosage: 50mg per day
Indication: Premedication
Start date: 2006-12-11
End date: 2006-12-11
Decadron
Dosage: 20mg per day
Indication: Premedication
Start date: 2006-12-11
End date: 2006-12-11
Kytril
Dosage: 3mg per day
Indication: Premedication
Start date: 2006-12-11
End date: 2006-12-11
Other drugs received by patient: Unknown Medication; Pursennid; Magnesium Oxide; Flomox; Solantal; Slow-FE; Seishoku; Restamin; Paclitaxel; Pirarubicin Hydrochloride; Carboplatin
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