Zantac (Ranitidine Hydrochloride) - Summary

ZANTAC SUMMARY

The active ingredient in ZANTAC Injection is ranitidine hydrochloride (HCl), a histamine H₂-receptor antagonist.

ZANTAC Injection is indicated in some hospitalized patients with pathological hypersecretory conditions or intractable duodenal ulcers, or as an alternative to the oral dosage form for short-term use in patients who are unable to take oral medication.

See all Zantac indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Zantac (Ranitidine)

Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily. [2010.04]
BACKGROUND: Systematic assessments of the onset of symptom relief in the treatment of gastroesophageal reflux disease (GERD) are lacking. OBJECTIVE: This work evaluated the time interval until complete symptom relief from heartburn (including both daytime and nighttime heartburn) and acid regurgitation in patients with GERD or endoscopy-negative GERD (NERD) during the first 7 days of treatment with pantoprazole, nizatidine, or ranitidine... CONCLUSION: In this post hoc reanalysis of data from 2 previously published clinical trials, use of pantoprazole 20 mg once daily was associated with effective early relief from heartburn and acid regurgitation among these patients with GERD and NERD; relief occurred as fast as and, in some cases, even faster than that seen with nizatidine or ranitidine.

Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily. [2010]
first 7 days of treatment with pantoprazole, nizatidine, or ranitidine... CONCLUSION: In this post hoc reanalysis of data from 2 previously published

Ranitidine is unable to maintain gastric pH levels above 4 in septic patients. [2009.12]
PURPOSE: The study aimed to evaluate whether ranitidine and pantoprazole are able to maintain gastric pH >or=4 in septic patients... CONCLUSIONS: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4.

Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. [2009.08]
BACKGROUND: Stress ulcer prophylaxis (SUP) using ranitidine, a histamine H2 receptor antagonist, has been associated with an increased risk of ventilator-associated pneumonia. The proton pump inhibitor (PPI) pantoprazole is also commonly used for SUP. PPI use has been linked to an increased risk of community-acquired pneumonia. The objective of this study was to determine whether SUP with pantoprazole increases pneumonia risk compared with ranitidine in critically ill patients... CONCLUSION: The use of pantoprazole for SUP was associated with a higher risk of nosocomial pneumonia compared with ranitidine. This relationship warrants further study in a randomized controlled trial.

Performance of acidified 14C-urea capsule breath test during pantoprazole and ranitidine treatment. [2009.07]
BACKGROUND AND AIM: Urea breath test (UBT) results could be false negative in patients taking antisecretory drugs. This effect would be prevented by citric acid administration during UBT. We prospectively investigated whether acidified 14C-urea capsule prevents false negative UBT results in patients taking antisecretory drugs and show interference with the duration of medications... CONCLUSIONS: The use of acidified 14C-urea capsule did not prevent false negative UBT results in patients taking pantoprazole and ranitidine, and the duration of medication does not affect the test results.

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Reports of Suspected Zantac (Ranitidine) Side Effects

Drug Ineffective (76),  Dyspepsia (39),  Malaise (35),  Dyspnoea (29),  Chronic Obstructive Pulmonary Disease (24),  Gastrooesophageal Reflux Disease (23),  Emphysema (23),  Nausea (22),  Amnesia (22),  Bedridden (21), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Zantac review by 46 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		excess acidity
Dosage & duration:		2 tabs per day taken twice per day for the period of 2 weeks
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		relief from burning associated with reflux
Side effects:		slight nausea during the first 24 hours.
Comments:		Part of my treatment plan was to undergo an endoscopy to find out what the problem was initially. The doctor who performed the endoscopy prescribed the Zantac. In the first 24 hour period I felt no differently, but the second day I started to feel alot better. At the end of the two weeks period of taking 2x tabs per day I felt completely back to normal. I ceased taking the Zantac after my follow up visit with the doctor but was advised to keep some handy for future use.

Zantac review by 40 year old male patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		acid reflux
Dosage & duration:		30 mg taken once/day for the period of 5 days
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		The Ranitidine can be taken at any, time throught out the day, with or without food, but should be taken with lots of water. can try 30 mag first then 60 mg etc. It can be taken up to 4 times per day.
Side effects:		no
Comments:		may have to repeat fairly often, how ever if you have serious acid problem, you may have to take Nexium for up to 2 months. The best is to check if you have H.pylori using a breath test, if you have HP then you have to take A HP pack or the cheaper alternative of nexium or pepacid + an antibiotic like Ammoxilin, the Hp pack is way overprice.

Zantac review by 59 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Reflux, Gastritis
Dosage & duration:		300 mg taken 1 per day for the period of 1 day
Other conditions:		DVT, asthma, allergies, depression
Other drugs taken:		coumadin, advair, protonix,levothroid, wellbutrin, allegra
		Reported Results
Benefits:		none
Side effects:		lump in throat, trouble breathing, tiredness, muscle pain
Comments:		Prescribed 300 mg, once a day at bedtime for severe reflux and gastritis. Took one pill and stared to have trouble breathing. Took Albuterol and in a couple of hours breathing returned to normal. Called doctor next morning and was told to discontinue use. Did not work to control reflux. Started on Pepcid the next day which along with Tums has made reflux managable.