Media Articles Related to Zanosar (Streptozocin)
Pancreatic cancer splits into four types, says genome study
Source: Genetics News From Medical News Today [2015.02.27]
A study of whole genomes and DNA variation in pancreatic tumors suggests there are four subtypes of the cancer depending on location, frequency and pattern of DNA rearrangement.
How the landscape of the pancreatic cancer genome is coming into view
Source: Genetics News From Medical News Today [2015.02.27]
Scientists from Australia and the UK have done the most in-depth analysis yet of 100 pancreatic cancer genomes and highlighted 4 subtypes that may help guide future patient treatment.
'Game-Changing' Research in Pancreatic Cancer
Source: Medscape Hematology-Oncology Headlines [2015.02.26]
The most comprehensive description to date of genomic events in pancreatic carcinogenesis has identified a patient subgroup with exceptional responses.
Medscape Medical News
Gene identified that lays foundation for pancreatic cancer
Source: Endocrinology News From Medical News Today [2015.02.23]
Researchers have identified a gene that affects the structure of pancreatic cells, laying the groundwork for pancreatic cancer to develop.
Potential pancreatic cancer treatment could increase life expectancy
Source: Breast Cancer News From Medical News Today [2015.02.08]
Device that drives drugs into solid tumors that are poorly vascularized opens the possibility of life-saving surgeries in cancer patientsPancreatic cancer cells are notorious for being protected...
Published Studies Related to Zanosar (Streptozocin)
Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in the treatment of advanced carcinoid tumors: Eastern Cooperative Oncology Group Study E1281. [2005.08.01]
PURPOSE: Optimal treatments for metastatic carcinoid tumor remain undefined, and the role of chemotherapy for symptomatic patients with progressive disease is uncertain... CONCLUSION: Response to all three treatment regimens were modest. FU/STZ improved survival compared with the doxorubicin-based regimen, suggesting that the combination should be considered to be an active regimen of therapy when chemotherapy is judged to be an option for selected patients with carcinoid tumors.
Chromium, Selenium, and Zinc Multimineral Enriched Yeast Supplementation Ameliorates Diabetes Symptom in Streptozocin-Induced Mice. [2011.11.12]
Chromium, selenium, and zinc malnutrition has been implicated in the pathogenesis of diabetic mellitus. This study aims to investigate the effects of novel multiminerals-enriched yeast (MMEY) which are minerals supplementation containing elevated levels of chromium, selenium, and zinc simultaneously in a diabetic animal model...
A single institution experience of streptozocin/fluorouracil combination chemotherapy: a case series. [2011.11.03]
CONCLUSION: FU/STZ was a well-tolerated regimen that produced significant benefit in the setting of metastatic and progressive disease. Our case series demonstrated comparable progression-free survival and overall survival in relation to randomized controlled studies and previous case series.
[Effects of electroacupuncture on expression of Abeta positive cells of the hippocampus and SOD activity in rats with streptozocin-Alzheimer's disease]. [2010.12]
OBJECTIVE: To investigate the possible mechanism of the electroacupuncture for improvement of learning and memory in rats of Alzheimer's disease (AD)... CONCLUSION: Electroacupuncture treatment can reduce the Abeta protein expression and increase the SOD activity of the hippocampus so as to improve learning and memory ability in the AD rats.
Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. [2010.09]
BACKGROUND: Type 1 diabetes is a chronic condition in which the pancreas produces little or no insulin due to the loss or dysfunction of pancreatic beta cells. This study investigated the beneficial effects of asiatic acid-a triterpenoid compound-preserved beta mass and mitigated hyperglycemia in streptozocin-induced diabetic rats... CONCLUSIONS: These results suggest that asiatic acid exerts its glucose-lowering effects, in part through influences on beta-cell mass. Asiatic acid administration resulted in preservation and restoration of beta-cell mass and function in diabetic rodent models. 2010 John Wiley & Sons, Ltd.
Clinical Trials Related to Zanosar (Streptozocin)
Capecitabine and Streptozocin With or Without Cisplatin in Treating Patients With Unresectable or Metastatic Neuroendocrine Tumors [Recruiting]
RATIONALE: Drugs used in chemotherapy, such as capecitabine, streptozocin, and cisplatin,
work in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. It is not yet known whether giving capecitabine together with
streptozocin is more effective with or without cisplatin in treating neuroendocrine tumors.
PURPOSE: This randomized phase II trial is studying giving capecitabine together with
streptozocin to see how well it works compared with or without cisplatin in treating
patients with unresectable or metastatic neuroendocrine tumors.
Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors [Recruiting]
Open label, single-arm phase II study of avastin combined with fluorouracil, doxorubicin and
streptozocin administered in 28-day cycles. Treatment will continue until progression of
disease, or until withdrawal due to toxicity, or up to a maximum of 12 cycles (48 weeks). In
order to reduce the risk of cardiac toxicity, doxorubicin will be administered for a maximum
of 8 cycles. If disease has not progressed after 12 cycles of treatment, avastin monotherapy
will continue until disease progression or withdrawal due to toxicity.
International Study: Comparison of Two Treatments for Adrenocortical Cancer [Recruiting]
- There is no medical consensus about the best treatment for advanced adrenocortical
cancer (ACC) that cannot successfully be treated with surgery alone.
- In 2003, the International Consensus Conference on Adrenal Cancer recommended two
chemotherapy regimens - etoposide, doxorubicin, cisplatin plus mitotane and
streptozotocin plus mitotane- as the best choices until better data could be obtained.
All the drugs in the two options have been shown effective against advanced ACC, but
they have different side effects.
- To determine which of the chemotherapy regimens described above is best to start with
in patients with ACC that cannot be surgically removed.
- To determine if there is a way to identify which patients will respond to a certain
- Patients 18 years of age and older from the USA, Scandinavia, Germany, Italy, France, The
Netherlands, Belgium, the UK, Canada and Australia who have adrenocortical cancer that
cannot be cured with surgery alone.
- Chemotherapy: Patients are randomly assigned to start with one of the two study
regimens. Patients whose tumor continues to grow during treatment are offered the
alternative therapy. All patients receive daily tablets of mitotane. In addition, they
have one of the following two regimens:
- Streptozotocin every 3 weeks for up to six cycles. The first cycle is given on days 1,
2, 3, 4 and 5 and subsequent cycles are given on day 1 only.
- Cisplatin plus etoposide plus doxorubicin every 4 weeks for up to six cycles.
Doxorubicin is given on day 1, etoposide is given on days 2, 3 and 4 and cisplatin is
given on days 3 and 4.
- CT scans of the chest, abdomen and pelvis approximately once every 8 weeks.
- Physical examination, routine blood tests and a check of side effects at the start of
each treatment cycle.
- Blood test to determine if the hormones produced by some adrenocortical cancers have
any effect on the immune system.
- Analysis of genetic markers in blood and tumor tissue for comparison with tumor growth
and patient survival to determine if this can help identify which patients will respond
to a certain therapy.
- Optional procedures:
- Storage of blood and tissue samples for future research.
- Completion of quality-of-life questionnaires every 2 months.
Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms [Active, not recruiting]
I. Assess the clinical response of patients with refractory or recurrent brain neoplasms
treated with carmustine, streptozocin, and mercaptopurine.
Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas [Completed]
Patients with Zollinger-Ellison Syndrome suffer from ulcers of the upper gastrointestinal
tract, higher than normal levels of gastric acid, and tumors of the pancreas known as
non-beta islet cell tumors.
Prior to the use of drugs to cure the ulcers, patients typically died due to severe ulcers.
Because of such effective drugs to treat the ulcers it is more common to see patients dying
due to the pancreatic tumors.
The study will observe patients suffering from Zollinger-Ellison Syndrome and non-beta islet
cell tumors and determine the effectiveness of combined chemotherapy with streptozotocin,
5-fluorouracil, and doxorubicin.