Media Articles Related to Zanosar (Streptozocin)
Pancreatic Cancer Surveillance Worth It in High-Risk Patients
Source: Medscape Hematology-Oncology Headlines [2016.04.27]
Surveillance of patients at high risk for pancreatic cancer is relatively successful in that it can detect potentially cancerous lesions at a resectable stage.
Medscape Medical News
Study Ties Certain Mouth Germs to Pancreatic Cancer Risk
Source: MedicineNet Obesity (Weight Loss) Specialty [2016.04.21]
Title: Study Ties Certain Mouth Germs to Pancreatic Cancer Risk
Category: Health News
Created: 4/20/2016 12:00:00 AM
Last Editorial Review: 4/21/2016 12:00:00 AM
Pancreatic cancer risk linked to changes in mouth bacteria
Source: Dentistry News From Medical News Today [2016.04.20]
For the first time, a new study gives direct evidence that certain changes in the oral microbiome - the mix of bacteria in the mouth - could be a risk factor for pancreatic cancer.
Researchers find method that could resurrect an abandoned pancreatic cancer targeted drug
Source: Pharma Industry / Biotech Industry News From Medical News Today [2016.04.19]
Pancreatic cancer is on track to become the second leading cause of cancer-related deaths by 2020.
Modified flu virus can 'resensitize' resistant pancreatic cancer cells to chemotherapy
Source: Flu / Cold / SARS News From Medical News Today [2016.04.15]
A common flu virus could be used to overcome patients' resistance to certain cancer drugs -- and improve how those drugs kill cancer cells, according to new research from Queen Mary University of...
Published Studies Related to Zanosar (Streptozocin)
Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in the treatment of advanced carcinoid tumors: Eastern Cooperative Oncology Group Study E1281. [2005.08.01]
PURPOSE: Optimal treatments for metastatic carcinoid tumor remain undefined, and the role of chemotherapy for symptomatic patients with progressive disease is uncertain... CONCLUSION: Response to all three treatment regimens were modest. FU/STZ improved survival compared with the doxorubicin-based regimen, suggesting that the combination should be considered to be an active regimen of therapy when chemotherapy is judged to be an option for selected patients with carcinoid tumors.
Chromium, Selenium, and Zinc Multimineral Enriched Yeast Supplementation Ameliorates Diabetes Symptom in Streptozocin-Induced Mice. [2011.11.12]
Chromium, selenium, and zinc malnutrition has been implicated in the pathogenesis of diabetic mellitus. This study aims to investigate the effects of novel multiminerals-enriched yeast (MMEY) which are minerals supplementation containing elevated levels of chromium, selenium, and zinc simultaneously in a diabetic animal model...
A single institution experience of streptozocin/fluorouracil combination chemotherapy: a case series. [2011.11.03]
CONCLUSION: FU/STZ was a well-tolerated regimen that produced significant benefit in the setting of metastatic and progressive disease. Our case series demonstrated comparable progression-free survival and overall survival in relation to randomized controlled studies and previous case series.
[Effects of electroacupuncture on expression of Abeta positive cells of the hippocampus and SOD activity in rats with streptozocin-Alzheimer's disease]. [2010.12]
OBJECTIVE: To investigate the possible mechanism of the electroacupuncture for improvement of learning and memory in rats of Alzheimer's disease (AD)... CONCLUSION: Electroacupuncture treatment can reduce the Abeta protein expression and increase the SOD activity of the hippocampus so as to improve learning and memory ability in the AD rats.
Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. [2010.09]
BACKGROUND: Type 1 diabetes is a chronic condition in which the pancreas produces little or no insulin due to the loss or dysfunction of pancreatic beta cells. This study investigated the beneficial effects of asiatic acid-a triterpenoid compound-preserved beta mass and mitigated hyperglycemia in streptozocin-induced diabetic rats... CONCLUSIONS: These results suggest that asiatic acid exerts its glucose-lowering effects, in part through influences on beta-cell mass. Asiatic acid administration resulted in preservation and restoration of beta-cell mass and function in diabetic rodent models. 2010 John Wiley & Sons, Ltd.
Clinical Trials Related to Zanosar (Streptozocin)
Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors [Terminated]
Open label, single-arm phase II study of avastin combined with fluorouracil, doxorubicin and
streptozocin administered in 28-day cycles. Treatment will continue until progression of
disease, or until withdrawal due to toxicity, or up to a maximum of 12 cycles (48 weeks). In
order to reduce the risk of cardiac toxicity, doxorubicin will be administered for a maximum
of 8 cycles. If disease has not progressed after 12 cycles of treatment, avastin monotherapy
will continue until disease progression or withdrawal due to toxicity.
Capecitabine and Streptozocin With or Without Cisplatin in Treating Patients With Unresectable or Metastatic Neuroendocrine Tumors [Completed]
RATIONALE: Drugs used in chemotherapy, such as capecitabine, streptozocin, and cisplatin,
work in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. It is not yet known whether giving capecitabine together with
streptozocin is more effective with or without cisplatin in treating neuroendocrine tumors.
PURPOSE: This randomized phase II trial is studying giving capecitabine together with
streptozocin to see how well it works compared with or without cisplatin in treating
patients with unresectable or metastatic neuroendocrine tumors.
Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms [Completed]
I. Assess the clinical response of patients with refractory or recurrent brain neoplasms
treated with carmustine, streptozocin, and mercaptopurine.
Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas [Completed]
Patients with Zollinger-Ellison Syndrome suffer from ulcers of the upper gastrointestinal
tract, higher than normal levels of gastric acid, and tumors of the pancreas known as
non-beta islet cell tumors.
Prior to the use of drugs to cure the ulcers, patients typically died due to severe ulcers.
Because of such effective drugs to treat the ulcers it is more common to see patients dying
due to the pancreatic tumors.
The study will observe patients suffering from Zollinger-Ellison Syndrome and non-beta islet
cell tumors and determine the effectiveness of combined chemotherapy with streptozotocin,
5-fluorouracil, and doxorubicin.
Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) [Completed]
The purpose of this study is to determine whether treatment with etoposide, doxorubicin,
cisplatin and mitotane (EDP/M) prolongs survival as compared to streptozotocin and mitotane
(Sz/M) in patients with advanced adrenocortical carcinoma (ACC) whose disease is not
amenable to complete surgical resection.