Zanaflex (Tizanidine Hydrochloride) - Summary

ZANAFLEX SUMMARY

Zanaflex^® (tizanidine hydrochloride) is a centrally acting α₂-adrenergic agonist.

Zanaflex (tizanidine) is indicated for the following:

Tizanidine is a short-acting drug for the management of spasticity. Because of the short duration of effect, treatment with tizanidine should be reserved for those daily activities and times when relief of spasticity is most important (see DOSING AND ADMINISTRATION).

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ZANAFLEX NEWS HIGHLIGHTS

Published Studies Related to Zanaflex (Tizanidine)

Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4. [2007.06]

Relative bioavailability of tizanidine 4-mg capsule and tablet formulations after a standardized high-fat meal: a single-dose, randomized, open-label, crossover study in healthy subjects. [2007.04]

Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers. [2006.09]

Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. [2006.09]

[The usefulness of tizanidine. A one-year follow-up of the treatment of spasticity in infantile cerebral palsy] [2006.08.01]

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Clinical Trials Related to Zanaflex (Tizanidine)

One Year Extension Study To Protocol C2/5/TZ:MS-05 [Not yet recruiting]

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