DRUG INTERACTIONS
Data are limited in regard to the interaction of YF-VAX® with other vaccines.
-
Measles (Schwartz strain) vaccine, diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP), 31 Hepatitis A and Hepatitis B vaccines, 2,12,32,33 meningococcal vaccine, Menomune® - A/C/Y/W-135, and typhoid vaccine, Typhim Vi®, 2,12,32 have been administered with yellow fever vaccine at separate injection sites.
-
No data exist on possible interference between yellow fever and rabies or Japanese encephalitis vaccines. 2
-
In a prospective study, persons given 5 cc of commercially available immune globulin did not experience alterations in immunologic responses to the yellow fever vaccine.2,34
-
The anti-malarial drug chloroquine has been administered with yellow fever vaccine.2,35
|
CONTRAINDICATIONS
HYPERSENSITIVITY
Because the yellow fever virus used in the production of this vaccine is propagated in chicken embryos, YF-VAX® should not be administered to anyone with a history of acute hypersensitivity to eggs or egg products; anaphylaxis may occur. Less severe or localized manifestations of allergy to eggs or to feathers are not contraindications to vaccine administration and do not usually warrant vaccine skin testing (see PRECAUTIONS section, Hypersensitivity Reactions subsection). Generally, persons who are able to eat eggs or egg products may receive the vaccine.2,22
INFANTS
Vaccination of infants less than 9 months of age IS CONTRAINDICATED because of the risk of encephalitis, and travel of such persons to rural areas in yellow fever endemic zones or to countries experiencing an epidemic should be postponed or avoided, whenever possible.
IMMUNOSUPPRESSED PATIENTS
Exposure to yellow fever vaccine, which is a live virus vaccine, poses a risk of encephalitis or other serious adverse events to patients with illnesses that commonly result in immunosuppression (eg, acquired immunodeficiency syndrome or other manifestations of human immunodeficiency virus (HIV) infection, leukemia, lymphoma, thymoma, generalized malignancy), or patients whose immunologic responses are suppressed by drug therapy (eg, corticosteroids, alkylating drugs, or antimetabolites) or radiation. Therefore, immunosuppressed subjects should not be immunized, and travel to yellow fever endemic areas should be postponed or avoided. If travel to a yellow fever-infected zone is unavoidable, immunosuppressed patients should be advised of the risk, instructed in methods for avoiding vector mosquitoes, and supplied with vaccination waiver letters by their physicians (see ADVERSE REACTIONS section).
Family members of immunosuppressed persons, who themselves have no contraindications, may receive yellow fever vaccine.2,23
|
