BOX WARNING
Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use. This risk increases with age and with heavy smoking (15 or more cigarettes per day) and is quite marked in women over 35 years of age. Women who use oral contraceptives should be strongly advised not to smoke.
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YASMIN SUMMARY
YASMIN 28 TABLETS
(drospirenone and ethinyl estradiol)
YASMIN provides an oral contraceptive regimen consisting of 21 active film coated tablets each containing 3.0 mg of drospirenone and 0.030 mg of ethinyl estradiol and 7 inert film coated tablets.
YASMIN is indicated for the prevention of pregnancy in women who elect to use an oral contraceptive.
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NEWS HIGHLIGHTSMedia Articles Related to Yasmin (Ethinyl Estradiol)
6 in 10 of America's Single Guys 'Take Responsibility' for Contraception
Source: MedicineNet Vasectomy Specialty [2017.08.31]
Title: 6 in 10 of America's Single Guys 'Take Responsibility' for Contraception
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 8/31/2017 12:00:00 AM
Published Studies Related to Yasmin (Ethinyl Estradiol)
[Efficacy and safety of a combined oral contraceptive containing drospirenone 3
mg and ethinylestradiol 20 µg in the treatment of premenstrual dysphoric
disorder: a randomized, double blind placebo-controlled study]. [Article in Chinese] [2014]
with placebo in reducing symptoms of premenstrual dysphoric disorder (PMDD)... CONCLUSIONS: YAZ could improve symptoms of PMDD better than placebo, while
An overview of four studies of a continuous oral contraceptive (levonorgestrel 90
mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual
syndrome. [2012]
and premenstrual syndrome (PMS)... CONCLUSIONS: These data, although not consistent, indicate that continuous LNG/EE
Ethinyl estradiol and levonorgestrel pharmacokinetics with a low-dose transdermal contraceptive delivery system, AG200-15: a randomized controlled trial. [2011.11.29]
BACKGROUND: This study evaluated the ethinyl estradiol (EE) and levonorgestrel (LNG) pharmacokinetic profiles of AG200-15, a transdermal contraceptive delivery system, compared with a combination oral contraceptive (COC) containing EE 35 mcg and norgestimate 250 mcg... CONCLUSIONS: EE and LNG daily exposure during AG200-15 treatment was within the range reported for a low-dose COC. The daily EE dose with AG 200-15 was equivalent to a 30-mcg COC and was safe and well tolerated. Copyright (c) 2011 Elsevier Inc. All rights reserved.
Effect of extended-cycle regimen with an oral contraceptive containing 30 mcg ethinylestradiol and 2 mg dienogest on bleeding patterns, safety, acceptance and contraceptive efficacy. [2011.08]
BACKGROUND: The present study compared the efficacy and safety of a combined oral contraceptive containing 30 mcg ethinylestradiol and 2 mg dienogest (EE/DNG) in conventional and extended-cycle regimen over 1 year of treatment... CONCLUSIONS: Extended-cycle use of EE/DNG was effective and mostly well tolerated, appearing to be a favorable option for women who need or wish to omit the pill-free interval. Copyright (c) 2011 Elsevier Inc. All rights reserved.
Effect of ticagrelor on the pharmacokinetics of ethinyl oestradiol and levonorgestrel in healthy volunteers. [2011.08]
BACKGROUND: Cytochrome P450 3 A is involved in ticagrelor and ethinyl oestradiol/levonorgestrel metabolism; so a potential drug-drug interaction may occur. OBJECTIVES: To assess: ticagrelor effects on ethinyl oestradiol/levonorgestrel pharmacokinetics, endogenous sex hormone levels; ethinyl oestradiol/levonorgestrel effects on ticagrelor pharmacokinetics; tolerability of ticagrelor + ethinyl oestradiol/levonorgestrel... CONCLUSIONS: Ticagrelor co-administration with ethinyl oestradiol/levonorgestrel increased ethinyl oestradiol exposure by approximately 20%, with no effect on levonorgestrel pharmacokinetics. No clinically relevant effect on contraceptive efficacy is expected with ethinyl oestradiol/levonorgestrel and ticagrelor co-administration.
Clinical Trials Related to Yasmin (Ethinyl Estradiol)
Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of Folate [Completed]
The purpose of this study is to examine and compare the uptake of levomefolate calcium
(Metafolin, a registered vitamin supplement) and folic acid in the body during 24 weeks of
treatment with a following folate elimination phase of 20 weeks in healthy volunteers
seeking contraception. Yasmin (oral contraceptive containing drospirenone and
ethinylestradiol) was co-administered over the entire period of 44 weeks.
A Study to Evaluate the Pharmacokinetics of an Oral Contraceptive When Co-administered With GSK2248761 in Healthy Adult Female Subjects. [Terminated]
This study is a two-period, double-blind study in healthy adult female subjects. Each
subject will participate in an oral contraceptive Run-in period prior to the treatment
periods. The length of the Run-in Period will be 28 days or longer, depending on the timing
of the subject's menstrual cycle and on whether the subject is taking an OC. Each subject
will participate in this run-in period (if needed), followed by two treatment periods.
Treatment Periods 1 and 2 must be conducted successively. Subjects will be randomized in a
cross-over fashion to either YASMIN with GSK2248761 or Placebo for 10 days and switch
GSK2248761 or placebo for another 10 days. Subjects will return to the study center for
final follow up evaluations 7 - 14 days after the final dose of study medication.
Comparison of Body Weight Change During Contraception With Belara and Yasmin [Enrolling by invitation]
The purpose of this study is to evaluate different side effect in contraceptive use of two
oral combined contraceptive pills (OCP)in combination of 30 mcg ethinylestradiol/2 mg
chlormadinone acetate (Belara®) and 30 mcg ethinylestradiol/3 mg drospirenone (Yasmin®),
especially body weight change.
LCS12 vs Combined Oral Contraceptive (COC) User Satisfaction Study [Completed]
The primary objective of this study is to evaluate user satisfaction and tolerability in
young women (18-29 years of age) using the LCS12 compared with young women using a COC
(Yasmin) over a period of 18 months. Subjects in the LCS12 arm will be offered continued use
of LCS12 for the full, intended duration of use (up to 3 years) by continuing in a optional,
extension phase. Safety data only will be collected during the extension phase of the study.
Secondary objectives are to observe the tolerability, discontinuation rates, adverse event
profiles, occurrences of unintended pregnancies (including calculation of Pearl Index [PI]),
and bleeding profiles with the two birth-control methods. Additionally, data on missed
tablets in the combined oral contraceptive (COC) group, and intrauterine delivery system
(IUS) expulsions in the LCS12 group will be recorded. In the LCS12 group, physician
satisfaction with the IUS inserter, evaluation of the visibility and texture of the removal
threads, and evaluation of the visibility of the LCS12 on ultrasound (in a subset of
subjects) will be collected. Finally, in the COC group, information will be collected on the
psychosocial impact of missed or delayed pill intake.
Yasmin 20 Cycle Control - Yasmin 20 Versus Mercilon in Healthy Female Volunteers [Completed]
Reports of Suspected Yasmin (Ethinyl Estradiol) Side Effects
Pain (6403),
Injury (5334),
Anxiety (3576),
Emotional Distress (3357),
Pulmonary Embolism (2965),
Deep Vein Thrombosis (2812),
General Physical Health Deterioration (1709),
Gallbladder Disorder (1683),
Cholecystitis Chronic (1660),
Anhedonia (1336), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 25 ratings/reviews, Yasmin has an overall score of 5.48. The effectiveness score is 8.88 and the side effect score is 6.08. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Yasmin review by 32 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | birth control, acne control |
| Dosage & duration: | | 1/day (dosage frequency: 1/day) for the period of 4 years |
| Other conditions: | | acne, hypothyroid |
| Other drugs taken: | | synthroid | | |
Reported Results |
| Benefits: | | Controlled acne very well when taken continuously. Eliminated PMS symptoms. Prevented pregnancy. Experienced minimal monthly bleeding. |
| Side effects: | | I did not experience any side effects. |
| Comments: | | 1 pill per day in the morning with food. Take 3 days off (placebo pills) before starting a new pack rather than a whole week. Take two pills the next day if a pill is missed. |
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| | Yasmin review by 26 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | Birth Control |
| Dosage & duration: | | i don't remember (dosage frequency: once a day) for the period of 2.5 months |
| Other conditions: | | Lazy thyroid |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Well, I had no babies.
Also, skin was a bit clearer and breasts got about half a cup bigger (but that came with the rest of my body getting bigger, too). |
| Side effects: | | I gained 10 lbs in just a couple months, I had period munchies all the time, and could always eat. I felt uncomfortable turning down food and seemed to have a never-ending appetite. This would subside during the sugar pill week.
I suspect, but am not sure, that Yasmin also gave me some vaginal dryness. I had frequent painful sex, would get raw very easily, and actually got a tear inside my vagina from sex. If we went at it twice a day it seemed I would need a day or two break just to recover. (None of this has happened before, so the doctor suggested I move to a lower dose pill.) |
| Comments: | | Take once a day at the same time everyday. |
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| | Yasmin review by 19 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Highly Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | Birth Control |
| Dosage & duration: | | 1 pill/day for 21 days taken once a day for the period of a year and a half |
| Other conditions: | | none |
| Other drugs taken: | | n/a | | |
Reported Results |
| Benefits: | | By taking Yasmin I did not get pregnant, as it did act as a proper birth control method. However the side effects outweighed the benefits and I was forced to switch to a new form of birth control. I would NEVER recommend this type of birth control. |
| Side effects: | | Severe depression, mood swings, weight gain, longer period, yeast infections, and numerous other effects. |
| Comments: | | 1 pill daily for 21 days and then a week break. |
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Page last updated: 2017-08-31
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