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Xyzal (Levocetirizine Dihydrochloride) - Summary

 
 



XYZAL SUMMARY

Levocetirizine dihydrochloride, the active component of XYZAL tablets and oral solution, is an orally active H1- receptor antagonist.

Allergic Rhinitis

XYZAL® is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.

Chronic Idiopathic Urticaria

XYZAL is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older.


See all Xyzal indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Xyzal (Levocetirizine)

Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial. [2011.12]
BACKGROUND: Compared with placebo, levocetirizine has been found to be less sedating than cetirizine in separate trials. However, whether levocetirizine is less sedating than its parent drug cetirizine has not yet been studied in a randomized trial. OBJECTIVE: To determine whether levocetirizine is less sedating than cetirizine... CONCLUSIONS: In patients with a perceived history of sedation with cetirizine, most were able to tolerate levocetirizine. However, this controlled trial also suggests that many of these patients would tolerate cetirizine if given in a masked manner. Therefore, patients with a history of mild to moderate sedation with cetirizine are unlikely to experience a different sedation profile with levocetirizine. Copyright (c) 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Anti-inflammatory activity and clinical efficacy of a 3-month levocetirizine therapy in mite-allergic children. [2011.02]
The non-sedating third generation antihistamine levocetirizine has ample evidence of efficacy in allergic rhinitis... This suggests that during treatment of mite-allergic children with levocetirizine the early improvement in nasal symptoms is due to the antihistamine activity, while more time is needed to achieve an effect on allergic inflammation.

Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011.01]
BACKGROUND: We assessed the course of treatment in patients with persistent allergic rhinitis (AR) treated with montelukast, levocetirizine, or desloratadine alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a gradual increase in nasal symptom improvement within 6 weeks of treatment in patients with persistent AR.

Nasal nitric oxide and nasal eosinophils decrease with levocetirizine in subjects with perennial allergic rhinitis. [2011]
in perennial allergic rhinitis (PAR) subjects... CONCLUSION: We showed that oral LC therapy decreased objective markers of

Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011]
alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a

more studies >>

Clinical Trials Related to Xyzal (Levocetirizine)

Omnaris Versus Levocetirizine Phase 4 Study [Recruiting]

The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism [Recruiting]
Levocetirizine (Xyzal®), the active levorotatory enantiomer of cetirizine (Zyrtec®), is a FDA-approved drug used in the treatment of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria. The parent compound, cetirizine was shown to be effective against experimental dermatographism, however no study has been conducted so far on the effect of levocetirizine on the inhibition of dermatographism. It is known that cetirizine is a mast-cell stabilizer and decreases histamine levels and the number of tryptase positive mast cells. Cetirizine inhibits the production of interleukin 8

(IL8) and leukotriene B4 (LTB4) by immune cells - two potent chemoattractants - and induces

the release from monocytes of prostaglandin E2 (PGE2), a suppressor of antigen presentation and MHC class II expression. However, the effects of the most active enantiomer levocetirizine on these inflammatory mediators have not been evaluated so far. Therefore, we aim to conduct a study in humans with dermatographism and chronic idiopathic urticaria to evaluate the effect of levocetirizine on the above-mentioned mediators. The study will involve the use of skin microdialysis, a minimally invasive technique to measure inflammatory mediators in the extracellular space in dermis.

Levocetirizine Plus Bed-Time Hydroxyzine in the Management of Corticodependent Chronic Urticaria Versus Both Drugs Alone in High Doses [Recruiting]
Allen Kaplan is a prominent American allergist with the reputation of leader in the field of chronic urticaria. He advocates treatment with first generation hydroxyzine, which he considers at least as effective as modern second generation H1-blockers in suppressing the symptoms of difficult-to-treat / systemic-steroid-dependant cases of chronic urticaria. He further speculates that hydroxyzine may have the advantage to better suppress itch and improve nighttime sleep. This has prompted many practitioners around the world to believe that adding hydroxyzine to the treatment regimen at bed time at night may be beneficial to patients. At the same time European guidelines indicate modern second generation H1-blockers in higher than conventional doses as drugs of choice for such cases. However, there is no evidence from clinical trials addressing this controversy. The investigators' previous studies suggest that levocetirizine at quadruple doses may be beneficial in difficult to treat urticaria by reducing lesions and itch, improving quality of life and night time sleep, while not causing day time somnolence. First generation H1-receptor antagonists and hydroxyzine among them are known to penetrate the blood / brain barrier and to cause sedation. The question stays whether this sedation is beneficial to the subjects with chronic urticaria at night, whether it has any hang-over unwanted effects the following day and whether this has any influence on the overall urticaria-specific quality of life.

Efficacy and Safety of Concomitant Montelukast Sodium and Levocetirizine Dihydrochloride in Perennial Allergic Rhinitis (PAR) Patients [Recruiting]

Levocetirizine + Capecitabine + Bevacizumab for Patients With Refractory Colorectal Cancer [Not yet recruiting]
Median progression-free survival (PFS) for patient with resistant colorectal cancer

more trials >>

Reports of Suspected Xyzal (Levocetirizine) Side Effects

Malaise (13)Alanine Aminotransferase Increased (13)Aspartate Aminotransferase Increased (12)Blood Bilirubin Increased (11)Dyspnoea (11)Gamma-Glutamyltransferase Increased (10)Decreased Appetite (10)Blood Lactate Dehydrogenase Increased (10)Pyrexia (9)Liver Disorder (9)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Xyzal has an overall score of 7.33. The effectiveness score is 7.33 and the side effect score is 7.33. The scores are on ten point scale: 10 - best, 1 - worst.
 

Xyzal review by 64 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   allergy/asthma
Dosage & duration:   1 daily (dosage frequency: as needed) for the period of still take it
Other conditions:   asthma, arthritis, thyroid
Other drugs taken:   levoxyl, singulair, flovent, simvastatin
  
Reported Results
Benefits:   Immediately saw improvement in allergy symptoms, which eased asthma
Side effects:   None that I noticed
Comments:   Initially, I took one tablet every night. I noticed that my allergy symptoms improved quickly. I could reduce my asthma inhalants as well, since it was improving with the reduction of my allergy symptoms. When the symptoms were alleviated, I took one tablet as needed, which was infrequently.

 

Xyzal review by 35 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   5mg taken once a day for the period of a few weeks
Other conditions:   none
Other drugs taken:   sudafed, mucinex
  
Reported Results
Benefits:   My allergies were a little better. My nose was not as runny.
Side effects:   I had extreme drowsiness. I could not even drive or think clearly. I had to discontinue taking it and go back to claritin. I even tried to take it at bed time. I still could not function the next day.
Comments:   I took the pill once a day for seasonal allergy symptoms.

 

Xyzal review by 35 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   5mg taken once a day for the period of a few weeks
Other conditions:   none
Other drugs taken:   sudafed, mucinex
  
Reported Results
Benefits:   My allergies were a little better. My nose was not as runny.
Side effects:   I had extreme drowsiness. I could not even drive or think clearly. I had to discontinue taking it and go back to claritin. I even tried to take it at bed time. I still could not function the next day.
Comments:   I took the pill once a day for seasonal allergy symptoms.

See all Xyzal reviews / ratings >>

Page last updated: 2013-02-10

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