XYZAL SUMMARY
Levocetirizine dihydrochloride, the active component of XYZAL tablets and oral solution, is an orally active H1- receptor antagonist.
Allergic Rhinitis
XYZAL® is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.
Chronic Idiopathic Urticaria
XYZAL is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older.
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NEWS HIGHLIGHTSMedia Articles Related to Xyzal (Levocetirizine)
Review Article Examines Sublingual Immunotherapy For Treatment Of Allergic Rhinitis And Asthma
Source: Allergy News From Medical News Today [2013.03.28]
In an examination of a type of treatment for allergic rhinitis and asthma that is used in Europe but not approved by the U.S. Food and Drug Administration, researchers found moderate strength in the evidence from previous studies to support the use of sublingual immunotherapy for the treatment of these conditions, according to an article in the March 27 issue of JAMA...
News From The Annals Of Internal Medicine: Feb. 19, 2013
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2013.02.20]
1. Acupuncture May be an Effective Alternative for Treating Seasonal Allergies Patients receiving acupuncture treatments for seasonal allergic rhinitis reported statistically significant improvements in symptoms and decreased use of medication compared to patients having standard treatment or sham acupuncture, but the clinical significance of the observed improvements is uncertain...
Published Studies Related to Xyzal (Levocetirizine)
Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial. [2011.12]
BACKGROUND: Compared with placebo, levocetirizine has been found to be less sedating than cetirizine in separate trials. However, whether levocetirizine is less sedating than its parent drug cetirizine has not yet been studied in a randomized trial. OBJECTIVE: To determine whether levocetirizine is less sedating than cetirizine... CONCLUSIONS: In patients with a perceived history of sedation with cetirizine, most were able to tolerate levocetirizine. However, this controlled trial also suggests that many of these patients would tolerate cetirizine if given in a masked manner. Therefore, patients with a history of mild to moderate sedation with cetirizine are unlikely to experience a different sedation profile with levocetirizine. Copyright (c) 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Anti-inflammatory activity and clinical efficacy of a 3-month levocetirizine therapy in mite-allergic children. [2011.02]
The non-sedating third generation antihistamine levocetirizine has ample evidence of efficacy in allergic rhinitis... This suggests that during treatment of mite-allergic children with levocetirizine the early improvement in nasal symptoms is due to the antihistamine activity, while more time is needed to achieve an effect on allergic inflammation.
Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. [2011.01]
BACKGROUND: We assessed the course of treatment in patients with persistent allergic rhinitis (AR) treated with montelukast, levocetirizine, or desloratadine alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a gradual increase in nasal symptom improvement within 6 weeks of treatment in patients with persistent AR.
Nasal nitric oxide and nasal eosinophils decrease with levocetirizine in subjects
with perennial allergic rhinitis. [2011]
in perennial allergic rhinitis (PAR) subjects... CONCLUSION: We showed that oral LC therapy decreased objective markers of
Use of montelukast alone or in combination with desloratadine or levocetirizine
in patients with persistent allergic rhinitis. [2011]
alone or combinations of antihistamine and montelukast... CONCLUSION: Montelukast alone or in combination with antihistamines gave a
Clinical Trials Related to Xyzal (Levocetirizine)
Omnaris Versus Levocetirizine Phase 4 Study [Recruiting]
The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism [Recruiting]
Levocetirizine (Xyzal®), the active levorotatory enantiomer of cetirizine (Zyrtec®), is a
FDA-approved drug used in the treatment of symptoms associated with seasonal and perennial
allergic rhinitis and chronic idiopathic urticaria. The parent compound, cetirizine was
shown to be effective against experimental dermatographism, however no study has been
conducted so far on the effect of levocetirizine on the inhibition of dermatographism. It is
known that cetirizine is a mast-cell stabilizer and decreases histamine levels and the
number of tryptase positive mast cells. Cetirizine inhibits the production of interleukin 8
(IL8) and leukotriene B4 (LTB4) by immune cells - two potent chemoattractants - and induces
the release from monocytes of prostaglandin E2 (PGE2), a suppressor of antigen presentation
and MHC class II expression. However, the effects of the most active enantiomer
levocetirizine on these inflammatory mediators have not been evaluated so far. Therefore, we
aim to conduct a study in humans with dermatographism and chronic idiopathic urticaria to
evaluate the effect of levocetirizine on the above-mentioned mediators. The study will
involve the use of skin microdialysis, a minimally invasive technique to measure
inflammatory mediators in the extracellular space in dermis.
Levocetirizine Plus Bed-Time Hydroxyzine in the Management of Corticodependent Chronic Urticaria Versus Both Drugs Alone in High Doses [Recruiting]
Allen Kaplan is a prominent American allergist with the reputation of leader in the field of
chronic urticaria. He advocates treatment with first generation hydroxyzine, which he
considers at least as effective as modern second generation H1-blockers in suppressing the
symptoms of difficult-to-treat / systemic-steroid-dependant cases of chronic urticaria. He
further speculates that hydroxyzine may have the advantage to better suppress itch and
improve nighttime sleep. This has prompted many practitioners around the world to believe
that adding hydroxyzine to the treatment regimen at bed time at night may be beneficial to
patients. At the same time European guidelines indicate modern second generation H1-blockers
in higher than conventional doses as drugs of choice for such cases. However, there is no
evidence from clinical trials addressing this controversy. The investigators' previous
studies suggest that levocetirizine at quadruple doses may be beneficial in difficult to
treat urticaria by reducing lesions and itch, improving quality of life and night time
sleep, while not causing day time somnolence. First generation H1-receptor antagonists and
hydroxyzine among them are known to penetrate the blood / brain barrier and to cause
sedation. The question stays whether this sedation is beneficial to the subjects with
chronic urticaria at night, whether it has any hang-over unwanted effects the following day
and whether this has any influence on the overall urticaria-specific quality of life.
Efficacy and Safety of Concomitant Montelukast Sodium and Levocetirizine Dihydrochloride in Perennial Allergic Rhinitis (PAR) Patients [Recruiting]
Levocetirizine + Capecitabine + Bevacizumab for Patients With Refractory Colorectal Cancer [Not yet recruiting]
Median progression-free survival (PFS) for patient with resistant colorectal cancer
Reports of Suspected Xyzal (Levocetirizine) Side Effects
Malaise (13),
Alanine Aminotransferase Increased (13),
Aspartate Aminotransferase Increased (12),
Blood Bilirubin Increased (11),
Dyspnoea (11),
Gamma-Glutamyltransferase Increased (10),
Decreased Appetite (10),
Blood Lactate Dehydrogenase Increased (10),
Pyrexia (9),
Liver Disorder (9), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Xyzal has an overall score of 7.33. The effectiveness score is 7.33 and the side effect score is 7.33. The scores are on ten point scale: 10 - best, 1 - worst.
| | Xyzal review by 64 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | allergy/asthma |
| Dosage & duration: | | 1 daily (dosage frequency: as needed) for the period of still take it |
| Other conditions: | | asthma, arthritis, thyroid |
| Other drugs taken: | | levoxyl, singulair, flovent, simvastatin | | |
Reported Results |
| Benefits: | | Immediately saw improvement in allergy symptoms, which eased asthma |
| Side effects: | | None that I noticed |
| Comments: | | Initially, I took one tablet every night. I noticed that my allergy symptoms improved quickly. I could reduce my asthma inhalants as well, since it was improving with the reduction of my allergy symptoms. When the symptoms were alleviated, I took one tablet as needed, which was infrequently. |
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| | Xyzal review by 35 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | allergies |
| Dosage & duration: | | 5mg taken once a day for the period of a few weeks |
| Other conditions: | | none |
| Other drugs taken: | | sudafed, mucinex | | |
Reported Results |
| Benefits: | | My allergies were a little better. My nose was not as runny. |
| Side effects: | | I had extreme drowsiness. I could not even drive or think clearly. I had to discontinue taking it and go back to claritin. I even tried to take it at bed time. I still could not function the next day. |
| Comments: | | I took the pill once a day for seasonal allergy symptoms. |
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| | Xyzal review by 35 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | allergies |
| Dosage & duration: | | 5mg taken once a day for the period of a few weeks |
| Other conditions: | | none |
| Other drugs taken: | | sudafed, mucinex | | |
Reported Results |
| Benefits: | | My allergies were a little better. My nose was not as runny. |
| Side effects: | | I had extreme drowsiness. I could not even drive or think clearly. I had to discontinue taking it and go back to claritin. I even tried to take it at bed time. I still could not function the next day. |
| Comments: | | I took the pill once a day for seasonal allergy symptoms. |
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Page last updated: 2013-03-28
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