ADVERSE REACTIONS
Systemic:
Adverse experiences following the administration of lidocaine HCl are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:
Central Nervous System:
CNS manifestations are excitatory and/or depressant and may be characterized by lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest. The excitatory manifestations may be very brief or may not occur at all, in which case the first manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest. Drowsiness following the administration of lidocaine HCl is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.
Cardiovascular System:
Cardiovascular manifestations are usually depressant and are characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest.
Allergic:
Allergic reactions are characterized by cutaneous lesions, urticaria, edema or anaphylactoid reactions. Allergic reactions may occur as a result of sensitivity either to local anesthetic agents or to the methylparaben used as a preservative in the multiple dose vials. Allergic reactions as a result of sensitivity to lidocaine HCl are extremely rare and, if they occur, should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.
Neurologic:
The incidences of adverse reactions associated with the use of local anesthetics may be related to the total dose of local anesthetic administered and are also dependent upon the particular drug used, the route of administration and the physical status of the patient. In a prospective review of 10,440 patients who received lidocaine for spinal anesthesia, the incidences of adverse reactions were reported to be about 3 percent each for positional headaches, hypotension and backache; 2 percent for shivering; and less than 1 percent each for peripheral nerve symptoms, nausea, respiratory inadequacy and double vision. Many of these observations may be related to local anesthetic techniques, with or without a contribution from the local anesthetic.
In the practice of caudal or lumbar epidural block, occasional unintentional penetration of the subarachnoid space by the catheter may occur. Subsequent adverse effects may depend partially on the amount of drug administered subdurally. These may include spinal block of varying magnitude (including total spinal block), hypotension secondary to spinal block, loss of bladder and bowel control, and loss of perineal sensation and sexual function. Persistent motor, sensory and/or autonomic (sphincter control) deficit of some lower spinal segments with slow recovery (several months) or incomplete recovery have been reported in rare instances when caudal or lumbar epidural block has been attempted. Backache and headache have also been noted following use of these anesthetic procedures.
There have been reported cases of permanent injury to extraocular muscles requiring surgical repair following retrobulbar administration.
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REPORTS OF SUSPECTED XYLOCAINE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Xylocaine. The information is not vetted and should not be considered as verified clinical evidence.
Possible Xylocaine side effects / adverse reactions in 63 year old male
Reported by a physician from France on 2011-10-03
Patient: 63 year old male
Reactions: Shock
Adverse event resulted in: life threatening event
Suspect drug(s):
Xylocaine
Start date: 2011-08-19
End date: 2011-08-19
Celocurine
Start date: 2011-08-19
End date: 2011-08-19
Propofol
Start date: 2011-08-19
End date: 2011-08-19
Atropine
Start date: 2011-08-19
End date: 2011-08-19
Possible Xylocaine side effects / adverse reactions in 50 year old female
Reported by a physician from Germany on 2011-10-04
Patient: 50 year old female
Reactions: Thrombocytopenia, Uterine Haemorrhage, Haematoma
Adverse event resulted in: hospitalization
Suspect drug(s):
Bupivacaine HCL
Indication: Infiltration Anaesthesia
Start date: 2011-01-31
Ciprofloxacin
Administration route: Oral
Indication: Upper Respiratory Tract Infection
Start date: 2011-01-25
End date: 2011-01-28
Levofloxacin
Administration route: Oral
Indication: Upper Respiratory Tract Infection
Start date: 2011-01-17
End date: 2011-01-24
Xylocaine
Indication: Infiltration Anaesthesia
Start date: 2011-01-31
Possible Xylocaine side effects / adverse reactions in 50 year old female
Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-04
Patient: 50 year old female weighing 76.0 kg (167.2 pounds)
Reactions: Thrombocytopenia, Uterine Haemorrhage, Haematoma
Adverse event resulted in: hospitalization
Suspect drug(s):
Levofloxacin
Administration route: Oral
Indication: Upper Respiratory Tract Infection
Start date: 2011-01-17
End date: 2011-01-24
Ciprofloxacin
Administration route: Oral
Indication: Upper Respiratory Tract Infection
Start date: 2011-01-25
End date: 2011-01-28
Xylocaine
Indication: Infiltration Anaesthesia
Start date: 2011-01-31
Bupivacaine HCL
Indication: Infiltration Anaesthesia
Start date: 2011-01-31
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