XYLOCAINE SUMMARY
Xylocaine®
(lidocaine HCl Injection, USP)
Xylocaine®
(lidocaine HCl and epinephrine Injection, USP)
For Infiltration and Nerve Block
Xylocaine (lidocaine HCl Injection, USP) is a sterile non-pyrogenic solution of an antiarrhythmic agent administered intravenously by direct injection.
Xylocaine administered intravenously is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.
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NEWS HIGHLIGHTSMedia Articles Related to Xylocaine (Lidocaine)
Sleep Disorders Linked to Arrhythmias
Source: MedicineNet Sleep Apnea Specialty [2009.06.24]
Title: Sleep Disorders Linked to Arrhythmias
Category: Health News
Created: 6/24/2009 7:00:00 AM
Last Editorial Review: 6/24/2009
Published Studies Related to Xylocaine (Lidocaine)
The analgesic effect of paracetamol when added to lidocaine for intravenous regional anesthesia. [2009.10]
BACKGROUND: In this study, we evaluated the effect of paracetamol on sensory and motor block onset time, tourniquet pain, and postoperative analgesia, when added to lidocaine in IV regional anesthesia (IVRA)... CONCLUSION: The addition of paracetamol during IVRA with lidocaine decreased tourniquet pain, increased anesthesia quality, and decreased postoperative analgesic consumption.
Flavored anesthetic lozenge versus Xylocaine spray used as topical pharyngeal anesthesia for unsedated esophagogastroduodenoscopy: a randomized placebo-controlled trial. [2009.09.03]
BACKGROUND: The use of Xylocaine spray has been the common practice in many endoscopy centers, but scientific evidence is not conclusive on its superiority over other forms of topical anesthesia. This study aimed to compare the effectiveness of Xylocaine spray as a topical pharyngeal anesthesia for upper endoscopy and that of anesthetic lozenges with a characteristic flavor... CONCLUSIONS: Topical Xylocaine spray is superior to the flavored anesthetic lozenge as a topical pharyngeal anesthesia in unsedated esophagogastroduodenoscopy.
Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. [2009.09.01]
BACKGROUND: The aim of this trial was to assess the relative efficacy of a sage/echinacea spray and a chlorhexidine/lidocaine spray in the treatment of acute sore throats... CONCLUSION: An echinacea/sage preparation is as efficacious and well tolerated as a chlorhexidine/lidocaine spray in the treatment of acute sore throats.
The impact of topical lidocaine on pain level assessment during and after vacuum-assisted closure dressing changes: a double-blind, prospective, randomized study. [2009.09]
BACKGROUND: Vacuum-assisted closure dressing changes are frequently painful. The authors hypothesized that administering topical lidocaine into the vacuum-assisted closure sponge would decrease pain during dressing changes... CONCLUSIONS: During the initial vacuum-assisted closure dressing change, 0.2% lidocaine administered through the suction tubing led to a reduction in pain reported by the patients in the authors' study. The duration of lidocaine administered in this fashion may be fairly short, because more patients in this group began to request small doses of opiates 30 minutes after the dressing change. Thus, lidocaine may improve patient comfort during vacuum-assisted closure therapy.
Lidocaine jelly and plain aqueous gel for urethral straight catheterization and the Q-tip test: a randomized controlled trial. [2009.09]
OBJECTIVE: To compare the pain perception between lidocaine and plain aqueous gel during assessment of postvoid residual volume and the Q-tip test... CONCLUSION: When compared with plain aqueous gel, 2% lidocaine jelly significantly reduces pain perception during evaluation of postvoid residual volume and the Q-tip test. LEVEL OF EVIDENCE: I.
Clinical Trials Related to Xylocaine (Lidocaine)
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be
performed with a lower total dose of local anesthesia (and greater patient safety) when using
0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.
Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to
alleviate the pain and discomfort associated with many of the procedures that children must
undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate
for children, physicians are urged to advocate for child-specific research in pain management
and the effective use of pain medication to ensure compassionate and competent management of
pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in
which children experience significant pain.(11) In present care, children over 2 months of
age do not routinely receive intervention for urethral catheterization related anxiety and
pain, and, anecdotal reports suggest that most require physical restraint to complete the
procedure. Lidocaine is an anesthetic agent that provides relief from pain during many
commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain
associated with urethral catheter placement in cystograms, however, Lidocaine is not
routinely used for urethral catheterizations in the CHOA ED.
This study aims to investigate the potential use of Lidocaine as an anesthetic agent during
urethral catheterization of children. Recently, two specific studies were performed
investigating the use of Lidocaine to decrease discomfort associated with urethral
catheterization. Using the strengths of both previously published studies, our study will use
Lidocaine both topically and instilled into the urethra. Investigators plan to perform a
prospective three-arm double-blinded randomized clinical trial investigating the
effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary
catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant
anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively
easy way to decrease pediatric pain in the emergency department setting.
Preemptive Analgesia for Postlaminectomy [Completed]
To relieve post laminectomy pain, we have tried intraoperative perineural injection of
lidocaine right after the exposure in expecting that this would be preemptive analgesia by
blocking the nerve transmission so that postoperative pain starts later and lighter.
Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods) [Active, not recruiting]
The purpose of this study is to determine whether lidocaine vaginal gel is safe and effective
for preventing or reducing the severity of dysmenorrhea (painful menstrual periods) compared
to placebo (inactive gel).
Jet Injection of 1% Buffered Lidocaine Versus Topical ELA-Max for Anesthesia Prior to Intravenous (IV) Catheterization in Children [Completed]
This trial is a comparison of the anesthetic effectiveness of J-Tip needle-free jet injection
of 1% buffered lidocaine to the anesthetic effectiveness of topical 4% ELA-Max for peripheral
intravenous catheter (PIV) insertion. The researchers hypothesize that the jet injection of
lidocaine will provide superior anesthesia to the ELA-Max prior to PIV insertion.
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