DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Xylocaine (Lidocaine Hydrochloride) - Summary

 
 



XYLOCAINE SUMMARY

Xylocaine®
(lidocaine HCl Injection, USP)
Xylocaine®
(lidocaine HCl and epinephrine Injection, USP)
For Infiltration and Nerve Block

Xylocaine (lidocaine HCl Injection, USP) is a sterile non-pyrogenic solution of an antiarrhythmic agent administered intravenously by direct injection.

Xylocaine administered intravenously is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.
See all Xylocaine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Xylocaine (Lidocaine)

Breakthrough in genetic engineering could advance study of arrhythmias and heart conduction
Source: Cardiovascular / Cardiology News From Medical News Today [2014.12.20]
Researchers at NYU Langone Medical Center have developed the first large animal model of an inherited arrhythmic syndrome - an advance that will lead to a better understanding of the biologic...

Cardiac arrhythmias reduced by thyroid hormones in rat model
Source: Cardiovascular / Cardiology News From Medical News Today [2014.12.16]
Rats that received thyroid hormones had a reduced risk for dangerous heart arrhythmias following a heart attack, according to a new study by a team of medical researchers at New York Institute of...

Finding could lead to treatments for channel-related diseases such as cardiac arrhythmias, epilepsy and Parkinson's
Source: Epilepsy News From Medical News Today [2014.10.30]
A common protein plays a different role than previously thought in the opening and closing of channels that let ions flow in and out of our cells, researchers at Johns Hopkins report.

more news >>

Published Studies Related to Xylocaine (Lidocaine)

Intraoperative systemic lidocaine for pre-emptive analgesics in subtotal gastrectomy: a prospective, randomized, double-blind, placebo-controlled study. [2014]
lidocaine infusion in patients who underwent subtotal gastrectomy... CONCLUSION: Intravenous lidocaine infusion reduces pain during the postoperative

Efficacy of intraperitoneal and intravenous lidocaine on pain relief after laparoscopic cholecystectomy. [2014]
infusion for postoperative pain control after laparoscopic cholecystectomy (LC)... CONCLUSIONS: The IP administration of lidocaine and IV lidocaine infusion

Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair removal: Phase-II and Phase-III study results. [2014]
peel"), which air-dries and can be peeled off 30 min post-application... CONCLUSIONS: After a 30-min application, LT peel was effective and well-tolerated

Reducing the pain of microemulsion propofol injections: a double-blind, randomized study of three methods of tourniquet and lidocaine. [2013]
of tourniquet application and lidocaine administration on MP injection pain... CONCLUSIONS: We concluded that intravenous retention of lidocaine with the

Higher dose cervical 2% lidocaine gel for IUD insertion: a randomized controlled trial. [2013]
for pain during intrauterine device (IUD) insertion... CONCLUSIONS: Two percent lidocaine gel placed on the anterior lip of the cervix

more studies >>

Clinical Trials Related to Xylocaine (Lidocaine)

Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.

J-Tip® Jet Injection of 1% Buffered Lidocaine or Saline Versus 4% Lidocaine Cream Before Venipuncture or IV Insertion [Not yet recruiting]
To measure and compare pain associated with venipuncture and peripheral intravenous catheter insertion among pediatric emergency department patients randomized to treatment with one of three different pain-reduction strategies: J-Tip® jet injection of 1% buffered lidocaine, J-Tip® jet injection of sterile saline, or application of 4% lidocaine topical cream. The investigators hypothesize that J-Tip® jet injection of 1% buffered lidocaine will provide superior local anesthesia compared to saline or lidocaine cream.

Lidocaine and Ketamine in Abdominal Surgery [Recruiting]
This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy. Participants will be randomized into one of four groups. Evaluations will be done through walking tests, pain and fatigue questionnaires and blood tests.

A Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine) [Recruiting]
To characterize the phenotype in patients with Morton's neuroma and to explore the effect of local administration of Xylocaine (lidocaine)

Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to alleviate the pain and discomfort associated with many of the procedures that children must undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate for children, physicians are urged to advocate for child-specific research in pain management and the effective use of pain medication to ensure compassionate and competent management of pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in which children experience significant pain.(11) In present care, children over 2 months of age do not routinely receive intervention for urethral catheterization related anxiety and pain, and, anecdotal reports suggest that most require physical restraint to complete the procedure. Lidocaine is an anesthetic agent that provides relief from pain during many commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain associated with urethral catheter placement in cystograms, however, Lidocaine is not routinely used for urethral catheterizations in the CHOA ED.

This study aims to investigate the potential use of Lidocaine as an anesthetic agent during urethral catheterization of children. Recently, two specific studies were performed investigating the use of Lidocaine to decrease discomfort associated with urethral catheterization. Using the strengths of both previously published studies, our study will use Lidocaine both topically and instilled into the urethra. Investigators plan to perform a prospective three-arm double-blinded randomized clinical trial investigating the effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively easy way to decrease pediatric pain in the emergency department setting.

more trials >>

Reports of Suspected Xylocaine (Lidocaine) Side Effects

Anaphylactic Shock (18)Convulsion (13)Angioedema (9)Toxicity TO Various Agents (9)Drug Rash With Eosinophilia and Systemic Symptoms (9)Tachycardia (8)Eosinophil Count Increased (8)Toxic Skin Eruption (8)Loss of Consciousness (7)Malaise (6)more >>


Page last updated: 2014-12-20

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2014