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Xylocaine (Lidocaine Hydrochloride) - Summary



Xylocaine (lidocaine HCl Injection, USP) is a sterile nonpyrogenic solution of an antiarrhythmic agent administered intravenously by direct injection. Xylocaine Injection is composed of an aqueous solution of lidocaine hydrochloride.

Xylocaine administered intravenously is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.

See all Xylocaine indications & dosage >>


Media Articles Related to Xylocaine (Lidocaine)

Predicting arrhythmias so as to prevent them
Source: Cardiovascular / Cardiology News From Medical News Today [2015.09.28]
Study of cardiac condition could lead to design of better cardiac deviceResearchers have discovered how to predict some cardiac arrhythmias several steps before they even occur.

ADHD medications linked to cardiac problems in children with hereditary heart disease
Source: ADHD / ADD News From Medical News Today [2015.07.07]
Long QT syndrome (LQTS), a rare hereditary heart condition, can lead to life-threatening arrhythmias, or fast heartbeat irregularities.

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Published Studies Related to Xylocaine (Lidocaine)

Intraoperative systemic lidocaine for pre-emptive analgesics in subtotal gastrectomy: a prospective, randomized, double-blind, placebo-controlled study. [2014]
lidocaine infusion in patients who underwent subtotal gastrectomy... CONCLUSION: Intravenous lidocaine infusion reduces pain during the postoperative

Efficacy of intraperitoneal and intravenous lidocaine on pain relief after laparoscopic cholecystectomy. [2014]
infusion for postoperative pain control after laparoscopic cholecystectomy (LC)... CONCLUSIONS: The IP administration of lidocaine and IV lidocaine infusion

Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair removal: Phase-II and Phase-III study results. [2014]
peel"), which air-dries and can be peeled off 30 min post-application... CONCLUSIONS: After a 30-min application, LT peel was effective and well-tolerated

Transversus abdominis plane block versus perioperative intravenous lidocaine versus patient-controlled intravenous morphine for postoperative pain control after laparoscopic colorectal surgery: study protocol for a prospective, randomized, double-blind controlled clinical trial. [2014]
BACKGROUND: Despite the laparoscopic approach becoming the standard in colorectal surgery, postoperative pain management for minimally invasive surgery is still mainly based on strategies that have been established for open surgical procedures... DISCUSSION: Recognizing the importance of a multimodal approach for perioperative pain management, we aim to investigate whether a transversus abdominis plane block delivers superior pain control in comparison to perioperative intravenous lidocaine and patient-controlled intravenous analgesia with morphine alone.

Intravenous lidocaine for the treatment of background or procedural burn pain. [2014]
CONCLUSIONS: As current clinical evidence is based on only one RCT as

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Clinical Trials Related to Xylocaine (Lidocaine)

Tumescent Lidocaine Maximum Safe mg/kg Dosage [Enrolling by invitation]
This pharmacokinetic clinical trial is a dose ranging study of lidocaine in tumescent local anesthesia. The goal is to understand the absorption pharmacokinetic of tumescent lidocaine and to determine an objective (statistical) estimate of the maximum safe mg/kg dosage of lidocaine in tumescent local anesthesia without liposuction.

Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving [Recruiting]
We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue memories. This will lead to a reduction in cue-induced craving upon repeated testing as well as subsequent cocaine use and basal craving.

A Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine) [Completed]
To characterize the phenotype in patients with Morton's neuroma and to explore the effect of local administration of Xylocaine (lidocaine)

The Effect of Pre-incisional Local Xylocaine Injection on Post Operative Pain and Scar Formation After Cesarean Section [Recruiting]
This study will examine whether pre-incision infiltration of the skin cut site can attenuate post operative pain after a cesarean section. One hundred and twenty women will be allocated to get 20 ml of either placebo or 1% xylocaine at the site of skin incision. We will also examine possible effect of this infiltration of parameters of wound heeling and scar formation, six weeks post partum.

Lidocaine: Effect of Lidocaine in Chronic Cough [Completed]
People cough in order to clear their airways. Most coughs are caused by viruses and settle down by themselves, but some people develop persistent coughing which can be anywhere from 8 weeks to several years. This is called chronic cough. People with chronic cough find the symptom distressing and it can have a major impact on their quality of life. Patients with chronic cough often report a sensation at the back of their throat which makes them feel an urge to cough. There is some evidence that Lidocaine (an anaesthetic used during medical procedures) can suppress a person's cough when given to patients via a nebuliser (a machine that turns liquid into a fine mist). It is currently unknown whether using a local anaesthetic, such as Lidocaine, in the form of a throat spray would successfully suppress a person's cough. A throat spray would be an easier treatment option in chronic cough patients. Thus, the investigators research aims to compare cough rates, severity and urge to cough scores between Lidocaine throat spray and nebulised Lidocaine.

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Reports of Suspected Xylocaine (Lidocaine) Side Effects

Anaphylactic Shock (18)Convulsion (13)Angioedema (9)Toxicity TO Various Agents (9)Drug Rash With Eosinophilia and Systemic Symptoms (9)Tachycardia (8)Eosinophil Count Increased (8)Toxic Skin Eruption (8)Loss of Consciousness (7)Malaise (6)more >>

Page last updated: 2015-09-28

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