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Xylocaine (Lidocaine Hydrochloride) - Summary

 
 



XYLOCAINE SUMMARY

Xylocaine®
(lidocaine HCl Injection, USP)
Xylocaine®
(lidocaine HCl and epinephrine Injection, USP)
For Infiltration and Nerve Block

Xylocaine (lidocaine HCl Injection, USP) is a sterile non-pyrogenic solution of an antiarrhythmic agent administered intravenously by direct injection.

Xylocaine administered intravenously is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.
See all Xylocaine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Xylocaine (Lidocaine)

Adding corticosteroids to local anesthetic injections for spinal stenosis showed little benefit
Source: Depression News From Medical News Today [2014.07.04]
Epidural injections with a glucocorticoid in combination with the local anesthetic lidocaine appear to be no better in reducing pain and physical limitations in patients with spinal stenosis, a...

Spinal Stenosis: No Added Benefit With Combo Injections
Source: MedPage Today Rheumatology [2014.07.03]
(MedPage Today) -- Epidural glucocorticoid-lidocaine injections for lumbar spinal stenosis did not improve pain or functioning at 6 weeks compared with epidural injections of lidocaine alone.

more news >>

Published Studies Related to Xylocaine (Lidocaine)

Cervical lidocaine for IUD insertional pain: a randomized controlled trial. [2012]
intracervical 2% lidocaine gel for pain relief with IUD insertion... CONCLUSION: Topical or intracervical 2% lidocaine gel prior to IUD insertion does

Treatment for postoperative wound pain in gynecologic laparoscopic surgery: topical lidocaine patches. [2012]
CONCLUSIONS: Topical lidocaine patches at the laparoscopic port sites reduced

Lidocaine/tetracaine patch (Rapydan) for topical anaesthesia before arterial access: a double-blind, randomized trial. [2012]
non-inferior to subcutaneous local anaesthetic... CONCLUSIONS: Both the lidocaine/tetracaine patch and subcutaneous injection of

Intravenous lidocaine for the treatment of background or procedural burn pain. [2012]
CONCLUSIONS: As current clinical evidence is based on only one single

Systemic lidocaine to improve postoperative quality of recovery after ambulatory laparoscopic surgery. [2012]
outpatient laparoscopic surgery... CONCLUSIONS: Systemic lidocaine improves postoperative quality of recovery in

more studies >>

Clinical Trials Related to Xylocaine (Lidocaine)

Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.

J-Tip® Jet Injection of 1% Buffered Lidocaine or Saline Versus 4% Lidocaine Cream Before Venipuncture or IV Insertion [Not yet recruiting]
To measure and compare pain associated with venipuncture and peripheral intravenous catheter insertion among pediatric emergency department patients randomized to treatment with one of three different pain-reduction strategies: J-Tip® jet injection of 1% buffered lidocaine, J-Tip® jet injection of sterile saline, or application of 4% lidocaine topical cream. The investigators hypothesize that J-Tip® jet injection of 1% buffered lidocaine will provide superior local anesthesia compared to saline or lidocaine cream.

Lidocaine and Ketamine in Abdominal Surgery [Recruiting]
This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy. Participants will be randomized into one of four groups. Evaluations will be done through walking tests, pain and fatigue questionnaires and blood tests.

A Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine) [Recruiting]
To characterize the phenotype in patients with Morton's neuroma and to explore the effect of local administration of Xylocaine (lidocaine)

Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to alleviate the pain and discomfort associated with many of the procedures that children must undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate for children, physicians are urged to advocate for child-specific research in pain management and the effective use of pain medication to ensure compassionate and competent management of pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in which children experience significant pain.(11) In present care, children over 2 months of age do not routinely receive intervention for urethral catheterization related anxiety and pain, and, anecdotal reports suggest that most require physical restraint to complete the procedure. Lidocaine is an anesthetic agent that provides relief from pain during many commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain associated with urethral catheter placement in cystograms, however, Lidocaine is not routinely used for urethral catheterizations in the CHOA ED.

This study aims to investigate the potential use of Lidocaine as an anesthetic agent during urethral catheterization of children. Recently, two specific studies were performed investigating the use of Lidocaine to decrease discomfort associated with urethral catheterization. Using the strengths of both previously published studies, our study will use Lidocaine both topically and instilled into the urethra. Investigators plan to perform a prospective three-arm double-blinded randomized clinical trial investigating the effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively easy way to decrease pediatric pain in the emergency department setting.

more trials >>

Reports of Suspected Xylocaine (Lidocaine) Side Effects

Anaphylactic Shock (18)Convulsion (13)Angioedema (9)Toxicity TO Various Agents (9)Drug Rash With Eosinophilia and Systemic Symptoms (9)Tachycardia (8)Eosinophil Count Increased (8)Toxic Skin Eruption (8)Loss of Consciousness (7)Malaise (6)more >>


Page last updated: 2014-07-04

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