Media Articles Related to Xolair (Omalizumab)
Xolair® improves rate of severe asthma exacerbations
Source: Doctors Lounge - Chest Diseases
Xolair reduced the rate of hospital emergency visits by 44% in patients with inadequately controlled asthma.
Every child with asthma, food allergies should have a school emergency plan
Source: Allergy News From Medical News Today [2014.09.11]
Only one in four students with asthma and half of children with food allergies have emergency health management plans in place at school, leaving schools inadequately prepared to manage daily needs...
New antibody-based treatment improves severe asthma care
Source: Respiratory / Asthma News From Medical News Today [2014.09.11]
A team of researchers at McMaster University and St. Joseph's Healthcare Hamilton have successfully evaluated a new, antibody-based drug for certain patients with severe asthma.
Investigating why asthma sufferers struggle with respiratory viruses
Source: Respiratory / Asthma News From Medical News Today [2014.09.10]
Study finds a key immune response to viruses is intact in asthma sufferers, suggesting the reason they struggle with respiratory viruses must lie elsewhere in the immune system.
Smoking Before Fatherhood May Raise Asthma Risk in Kids: Study
Source: MedicineNet Smoking and Quitting Smoking Specialty [2014.09.09]
Title: Smoking Before Fatherhood May Raise Asthma Risk in Kids: Study
Category: Health News
Created: 9/8/2014 12:36:00 PM
Last Editorial Review: 9/9/2014 12:00:00 AM
Published Studies Related to Xolair (Omalizumab)
Omalizumab and the risk of malignancy: results from a pooled analysis. 
pooled data from clinical trials of omalizumab-treated patients... CONCLUSIONS: In this pooled analysis no association was observed between
A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria. [2011.09]
BACKGROUND: Proof-of-concept studies with omalizumab in patients with chronic idiopathic urticaria (CIU) have shown significant decreases in mean urticaria activity scores (UASs). OBJECTIVE: We sought to evaluate the efficacy and safety of omalizumab in patients with CIU who remain symptomatic despite concomitant H(1)-antihistamine therapy... CONCLUSION: This study demonstrated that a fixed dose of 300 or 600 mg of omalizumab provides rapid and effective treatment of CIU in patients who are symptomatic despite treatment with H(1)-antihistamines. Copyright (c) 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. [2011.07]
BACKGROUND: A subgroup of patients with chronic spontaneous urticaria (CU) exhibits IgE antibodies directed against autoantigens, such as thyroperoxidase (TPO). We conducted this study to investigate whether such patients with CU with IgE against TPO benefit from treatment with omalizumab, a humanized anti-IgE mAb licensed for the treatment of severe persistent allergic (IgE-mediated) asthma. OBJECTIVES: We sought to assess the efficacy of omalizumab treatment in patients with CU with IgE autoantibodies against TPO... CONCLUSIONS: The results of this study indicate that omalizumab is an effective treatment option for patients with CU with IgE autoantibodies against TPO who are refractory to conventional treatment. Copyright (c) 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. [2011.05.03]
BACKGROUND: Inhaled corticosteroids (ICS) and long-acting beta(2)-agonists (LABAs) are recommended in patients with asthma that is not well-controlled; however, many patients continue to have inadequately controlled asthma despite this therapy. OBJECTIVE: To evaluate the efficacy and safety of omalizumab in patients with inadequately controlled severe asthma who are receiving high-dose ICS and LABAs, with or without additional controller therapy... CONCLUSION: In this study, omalizumab provided additional clinical benefit for patients with severe allergic asthma that is inadequately controlled with high-dose ICS and LABA therapy. Primary Funding Source: Genentech and Novartis Pharmaceuticals.
Persistency of response to omalizumab therapy in severe allergic (IgE-mediated) asthma. [2011.05]
BACKGROUND: The physician's global evaluation of treatment effectiveness (GETE) at 16 weeks has been shown to be the most effective assessment of response to omalizumab (XOLAIR(R)). This randomized, open-label, parallel-group study evaluated the persistency of treatment responder classification in patients receiving omalizumab added to optimized asthma therapy (OAT)... CONCLUSION: Response to omalizumab, as assessed by a physician's GETE at 16 weeks, is an effective predictor of continuing persistent response to omalizumab for the majority of patients. (c) 2011 John Wiley & Sons A/S.
Clinical Trials Related to Xolair (Omalizumab)
Study to Evaluate the Effect of Xolair(Omalizumab) on Improving the Tolerability of Specific Immunotherapy in Patients With at Least Moderate Persistent Allergic Asthma Inadequately Controlled With Inhaled Corticosteroids [Completed]
In patients with at least moderate persistent allergic asthma controlled with inhaled
steroids, omalizumab (administered per US product label), when compared to placebo, will
provide the participants with significantly improved tolerability of specific allergen
immunotherapy (allergy shots) administered per a cluster schedule(rapid build up method).
The Effect of Xolair (Omalizumab) on Allergy Blood Cells [Recruiting]
We are studying Xolair (omalizumab) to see it's effect on allergic blood cells. The blood
tests will be done in a test tube to see if they react differently before and after
treatment. The blood cells will be mixed with to whatever the person is allergic.
Effect of Xolair on Airway Hyperresponsiveness [Recruiting]
The purpose of this study is to determine if Xolair can reduce the abnormal increase in
limitation to airflow in patients with asthma in a relatively short time period. Another
purpose is to determine if Xolair will decrease the amount of inflammation in the lungs of
an asthmatic patient in the same time period.
Effect of Ozone on Airway Inflammation in Allergic Asthmatics Treated With Omalizumab [Terminated]
Ozone can cause acute airway inflammation in both asthmatics and normal volunteers. However,
in asthmatics ozone can cause episodes of worsening of asthma. We want to learn if chronic
allergic response, known as "IgE-induced airway inflammation" is what causes the increased
inflammation in response to ozone. To do this we will examine the response to ozone in a
group of asthmatics treated with omalizumab, a medicine available and approved for use in
people with asthma, or a placebo control. The placebo for this study is inert physiologic
saline ("salt water") which contains no omalizumab. Both the omalizumab and the placebo will
be administered as an injection under the skin. Omalizumab, also called Xolair, is a
humanized monoclonal antibody, which means that it originally was produced in mice, then
genetically engineered to look more like human than mouse antibody. Omalizumab inactivates
IgE, a protein our own immune systems make as part of allergic reactions. The purpose of this
study is to test the hypothesis that omalizumab, by blocking this aspect of allergic
reactions, will decrease the number of inflammatory cells in the airway after ozone
challenge. We also hypothesize that omalizumab will decrease the effects of ozone on changes
in lung function, mucociliary clearance (a measure of how quickly mucus clears form the
airway) and airway reactivity. Airway reactivity is a measure of how sensitive the airways
are to a medication used to diagnose asthma, called methacholine. We will examine these as
additional information we can learn during the course of the study. This is a blinded study,
meaning that neither you nor the researchers know if you get the active drug or placebo, but
that information can be obtained if needed. The placebo is an injection of inert
physiological saline ("salt water") which contains no omalizumab.
Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair [Recruiting]
The purpose of this study is to study the effects of Xolair using non-invasive techniques
from the expired gas of patients with moderate to severe allergic asthma.
Reports of Suspected Xolair (Omalizumab) Side Effects
Blood Pressure Increased (178),
Headache (169), more >>