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Xifaxan (Rifaximin) - Summary

 
 



XIFAXAN SUMMARY

XIFAXAN (rifaximin) Tablets
(zuh FAX in)

XIFAXAN™ Tablets contain rifaximin, a semi-synthetic, non-systemic antibiotic.

XIFAXAN™ Tablets are indicated for the treatment of patients (>/=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli (see WARNINGS, Microbiology, and CLINICAL STUDIES).

XIFAXAN™ Tablets should not be used in patients with diarrhea complicated by fever or blood in the stool or diarrhea due to pathogens other than Escherichia coli.


See all Xifaxan indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Xifaxan (Rifaximin)

Rifaximin (Xifaxan) for Irritable Bowel Syndrome (IBS) Treatment
Source: MedicineNet Constipation Specialty [2014.12.01]
Title: Rifaximin (Xifaxan) for Irritable Bowel Syndrome (IBS) Treatment
Category: Doctor's Views
Created: 1/18/2011 12:00:00 AM
Last Editorial Review: 12/1/2014 12:00:00 AM

Salix's TARGET 3 study examines the safety and efficacy of repeat treatment with Rifaximin for IBS with diarrhea
Source: Irritable-Bowel Syndrome News From Medical News Today [2014.10.23]
Salix Pharmaceuticals, Ltd. has announced that Dr. Anthony Lembo of Beth Israel Deaconess Medical Center will present the results of TARGET 3 in a late-breaking podium presentation at the American...

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Published Studies Related to Xifaxan (Rifaximin)

Safety and tolerability of rifaximin for the treatment of irritable bowel syndrome without constipation: a pooled analysis of randomised, double-blind, placebo-controlled trials. [2014]
events (AEs) in phase 2b and phase 3 non-C IBS trials... CONCLUSIONS: The safety and tolerability profile of rifaximin during treatment

[Role of rifaximin in the treatment of colonic diverticular disease]. [Article in Italian] [2012]
Diverticular disease of the colon is the fifth most important gastrointestinal disease in terms of direct and indirect healthcare costs in western countries. Although most patients with colonic diverticula remain asymptomatic for their whole life, in 20-25% of cases will develop symptoms.No definitive conclusion can be drawn regard a possible role of rifaximin for preventing diverticulitis.

Double-blind randomized controlled trial of rifaximin for persistent symptoms in patients with celiac disease. [2011.10]
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is one cause of a poor response to a gluten-free diet (GFD) and persistent symptoms in celiac disease. Rifaximin has been reported to improve symptoms in non-controlled trials. AIMS: To determine the effect of rifaximin on gastrointestinal symptoms and lactulose-hydrogen breath tests in patients with poorly responsive celiac disease... CONCLUSIONS: Rifaximin does not improve patients' reporting of gastrointestinal symptoms and hydrogen breath tests do not reliably identify who will respond to antibiotic therapy.

Rifaximin: new therapeutic indication and future directions. [2011.07]
BACKGROUND: Rifaximin is a nonabsorbable oral antibiotic that acts locally in the gastrointestinal tract with minimal systemic adverse effects. Rifaximin received new labeling for reduction in the risk of the recurrence of overt hepatic encephalopathy (HE) in patients with advanced liver disease in March of 2010. OBJECTIVE: This article reviews the pharmacology, pharmacokinetics, and pharmacodynamics of rifaximin. The efficacy and safety of rifaximin in reducing the risk of the recurrence of overt HE in patients with advanced liver disease, the new US Food and Drug Administration-approved indication, is the focus of this review. Emerging data on the use of rifaximin in irritable bowel syndrome (IBS) and Clostridium difficile infection (CDI) are also evaluated... CONCLUSIONS: Rifaximin can be an effective option for reduction in the risk of the recurrence of HE in patients with advanced liver disease. Studies suggest that rifaximin provides relief of global symptoms of diarrhea-predominant IBS and bloating. Use of rifaximin in CDI requires further study. Copyright (c) 2011 Elsevier HS Journals, Inc. All rights reserved.

Efficacy of levofloxacin and rifaximin based quadruple therapy in Helicobacter pylori associated gastroduodenal disease: a double-blind, randomized controlled trial. [2011.06]
The aim of this study was to evaluate the efficacy of levofloxacin and rifaximin based quadruple regimen as first-line treatment for Helicobacter pylori infection. A prospectively randomized, double-blinded, parallel group, comparative study was performed...

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Clinical Trials Related to Xifaxan (Rifaximin)

Rifaximin Treatment of Papulopustular Rosacea [Not yet recruiting]
The purpose of this study is to determine the effects of rifaximin on skin symptoms in patients with rosacea by double-blinded, placebo-controlled, crossover study.

A Pilot Study of Xifaxan to Treat Patients With PSC [Recruiting]
In the current protocol, we propose the assessment of potential beneficial effects of the antibiotic Xifaxan on liver biochemistries, liver related symptoms and Mayo risk score in 15 adult and 5 pediatric patients with PSC. Adult patients will receive Xifaxan, 550 mg twice daily over a 12-week period. Pediatric patients with PSC whose weight is greater than or equal to 40 kg will receive Xifaxan, 550 mg twice daily.

Rifaximin and Placebo in the Treatment of Bowel Dysfunction After Anterior Resection for Rectal Cancer [Recruiting]
The most common long-term problems after rectal surgery are bowel problems. These problems can include needing to pass bowel movements a lot, loose or mushy stools, inability to fully clear your bowels, and/or poor control of gas and stool. The investigators believe that a major cause of these problems is too much bacteria in the bowel and treatment with antibiotic tablets will hopefully help improve these bowel problems. In order to test this idea, the Colorectal Surgery Service of Memorial Sloan Kettering Cancer Center is sponsoring a clinical trial. This trial will compare the antibiotic rifaximin and a placebo (a harmless tablet that has no effect) in the treatment of these bowel problems. Rifaximin is a well established drug that has minimal side effects.

Study of Rifaximin in Minimal Hepatic Encephalopathy [Recruiting]
Rifaximin therapy will improve brain functioning on MRI scanning.

Rifaximin for Preventing Acute Graft Versus Host Disease (AGVHD) [Recruiting]
Acute graft versus host disease is a frequent and often life threatening complication of allogeneic blood and marrow transplantation. The bacteria that normally reside in the intestine play a critical role in its development. Injury to the lining of the bowel that results from the high dose chemotherapy or radiation that transplant patients receive during the week preceding the transplant allows the bacteria to invade the intestines and spread to nearby lymph nodes. This, in turn, causes inflammation which has been shown to promote GVHD. Both pre-clinical and clinical research has demonstrated that oral antibiotics can prevent graft versus host disease by inhibiting these gut bacteria. Rifaximin has several features that suggest it could be effective in preventing GVHD. Rifaximin prophylaxis might also provide an added benefit by protecting highly immunocompromised transplant patients from severe bacterial infections. This pilot trial will allow the investigators to determine the feasibility of using Rifaximin for prevention of GVHD and infection in patients undergoing allogeneic blood and marrow transplantation. The preliminary results will be used to plan a more definitive trial.

more trials >>

Reports of Suspected Xifaxan (Rifaximin) Side Effects

Renal Failure (5)Colitis Ischaemic (3)Staphylococcal Infection (3)Pancreatitis (3)Enterococcal Infection (2)Hepatic Failure (2)Headache (2)Fall (2)Bacterial Prostatitis (2)Oedema Peripheral (2)more >>


Page last updated: 2014-12-01

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