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Xanax XR (Alprazolam) - Summary



(alprazolam) extended-release tablets

XANAX XR Tablets contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds.

XANAX XR Tablets are indicated for the treatment of panic disorder, with or without agoraphobia.

This claim is supported on the basis of two positive studies with XANAX XR conducted in patients whose diagnoses corresponded closely to the DSM-III-R/IV criteria for panic disorder (see CLINICAL STUDIES).

Panic disorder (DSM-IV) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: (1) palpitations, pounding heart, or accelerated heart rate; (2) sweating; (3) trembling or shaking; (4) sensations of shortness of breath or smothering; (5) feeling of choking; (6) chest pain or discomfort; (7) nausea or abdominal distress; (8) feeling dizzy, unsteady, lightheaded, or faint; (9) derealization (feelings of unreality) or depersonalization (being detached from oneself); (10) fear of losing control; (11) fear of dying; (12) paresthesias (numbness or tingling sensations); (13) chills or hot flushes.

The longer-term efficacy of XANAX XR has not been systematically evaluated. Thus, the physician who elects to use this drug for periods longer than 8 weeks should periodically reassess the usefulness of the drug for the individual patient.

See all Xanax XR indications & dosage >>


Published Studies Related to Xanax XR (Alprazolam)

Comparison of alprazolam versus captopril in high blood pressure: a randomized controlled trial. [2011.08]
CONCLUSION: A significant association exists between the level of BP and anxiety in hypertensive ED patients. Alprazolam is as effective as captopril in lowering BP in ED patients with an initial SBP > 160 mmHg.

Efficacy of alprazolam sublingual tablets in the treatment of the acute phase of panic disorders. [2011.03]
CONCLUSIONS: Alprazolam has been demonstrated to have efficacy, safety and good tolerability in the treatment of the acute phase of panic disorder, the sublingual tablets showing some comparative advantages.

The efficacy and safety of alprazolam versus other benzodiazepines in the treatment of panic disorder. [2011]
We performed a meta-analysis of all single- or double-blind, randomized controlled trials comparing alprazolam to another benzodiazepine in the treatment of adult patients meeting the Diagnostic and Statistical Manual of Mental Disorders, Third or Fourth Edition, criteria for panic disorder or agoraphobia with panic attacks...

The effects of alprazolam on tinnitus: a cross-over randomized clinical trial. [2009.11]
CONCLUSIONS: These results suggest that although alprazolam did not improve the THI score or sensation level of loudness significantly, it has a desirable effect on VAS. Further work is needed to determine the beneficial effects of alprazolam in distressed or depressed patients.

Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial. [2009.05]
The respiratory effects of benzodiazepines have been controversial...

more studies >>

Clinical Trials Related to Xanax XR (Alprazolam)

An Bioequivalence Study Of Xanax Extended Release Tablets From Two Different Manufacturing Sites [Completed]
Study to evaluate if Xanax sustained release tablets manufactured at two different sites provide similar drug levels in the blood.

A Study Of Two Oral Preparations Of 2 Mg Alprazolam In Healthy Volunteers Under Fasting Conditions [Withdrawn]
The purpose of this study is to compare bioavailability between formulations of alprazolam in tablets to determine their bioequivalence in terms of rate and magnitude of absorption.

Pharmacokinetics Of Alprazolam Sublingual Tablet Versus Conventional Tablet [Completed]
To assess if the sublingual tablet will have similar pharmacokinetics as the conventional tablet of alprazolam.

Bioequivalence Study Comparing Two Alprazolam 1 mg Tablets Under Fed Conditions [Completed]
The objective of the study is to demonstrate the bioequivalence (BE) of alprazolam 1 mg tablet with Xanax® 1 mg tablet under fed conditions.

Bioequivalence of a New Sublingual and a Reference Alprazolam Immediate Release Tablet Formulation [Withdrawn]
This study tests the assumption that the bioavailability of alprazolam from a new sublingual formulation is the same as that from an existing commercial immediate release tablet formulation.

more trials >>

Reports of Suspected Xanax XR (Alprazolam) Side Effects

Malaise (14)Drug Ineffective (10)Fatigue (8)Feeling Abnormal (7)Anxiety (6)Somnolence (5)Drug Intolerance (5)Mental Disorder (5)Depression (4)Anaphylactic Reaction (3)more >>


Based on a total of 1 ratings/reviews, Xanax XR has an overall score of 8. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.

Xanax XR review by 38 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   Anxiety Rapid Onset
Dosage & duration:   .5 (dosage frequency: once daily xr) for the period of 20-30 for effectiveness
Other conditions:   Sudden anxiety for 1st time
Other drugs taken:   None
Reported Results
Benefits:   Xanax XR .5 once daily for 2 days. This med works within 20-30 mins. A good solution for fast anxiety relief, as opposed to waiting 2 weeks for it to "settle" into your system. I think I might have done fine with .25 instead of the .50. However, just reading about other people's anxiety accounts and Xanax has given me anxiety!
Side effects:   A wee lethargic, but welcome feeling compared to... you know dying and hyperventilating. :) Definately tired. Maybe some minor bowel disturbances. I am concerned about withdrawal so plan to take it on an as needed basis only!
Comments:   Xanax XR .5 once daily for 2 days now.

See all Xanax XR reviews / ratings >>

Page last updated: 2013-02-10

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