Warfarin (Warfarin Sodium) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The following serious adverse reactions to warfarin sodium are discussed in greater detail in other sections of the labeling:

• Hemorrhage [see Boxed Warning, Warnings and Precautions (5.1), and Overdosage (10)]
• Necrosis of skin and other tissues [see Warnings and Precautions ]
• Systemic atheroemboli and cholesterol microemboli [see Warnings and Precautions]
• Other adverse reactions to warfarin sodium include:
• Immune system disorders: hypersensitivity/allergic reactions (including urticaria and anaphylactic reactions)
• Vascular disorders: vasculitis
• Hepatobiliary disorders: hepatitis elevated liver enzymes. Cholestatic hepatitis has been associated with concomitant administration of warfarin sodium and ticlopidine.
• Gastrointestinal disorders: nausea, vomiting, diarrhea, taste perversion, abdominal pain, flatulence, bloating
• Skin disorders: rash, dermatitis (including bullous eruptions), pruritus, alopecia
• Respiratory disorders: tracheal or tracheobronchial calcification  
• General disorders: chills

REPORTS OF SUSPECTED WARFARIN SIDE EFFECTS / ADVERSE REACTIONS

Possible Warfarin side effects / adverse reactions in 81 year old male

Reported by a pharmacist from United States on 2011-12-21

Patient: 81 year old male weighing 58.0 kg (127.6 pounds)

Reactions: Rhabdomyolysis, International Normalised Ratio Increased, Drug Interaction, Blue TOE Syndrome, Transaminases Increased, Renal Failure Acute

Adverse event resulted in: hospitalization

Suspect drug(s):
Warfarin
    Administration route: Oral

Zocor
    Administration route: Oral
    Start date: 2007-01-01

Gemfibrozil
    Administration route: Oral
    Start date: 2005-01-01

Other drugs received by patient: Acetaminophen and Codeine; Lisinopril; Nortriptyline; Aspirin

Possible Warfarin side effects / adverse reactions in 82 year old male

Reported by a physician from United States on 2011-12-22

Patient: 82 year old male

Reactions: Completed Suicide, Toxicity TO Various Agents

Adverse event resulted in: death

Suspect drug(s):
Pregabalin
    Dosage: unk
    Administration route: Oral

Cyclobenzaprine
    Dosage: unk
    Administration route: Oral

Acetaminophen and Hydrocodone Bitartrate
    Dosage: unk
    Administration route: Oral

Warfarin
    Dosage: unk
    Administration route: Oral

Amlodipine Besylate
    Dosage: unk
    Administration route: Oral

Methadone
    Dosage: unk
    Administration route: Oral

Hydroxychloroquine
    Dosage: unk
    Administration route: Oral

Possible Warfarin side effects / adverse reactions in 36 year old male

Reported by a physician from Japan on 2011-12-23

Patient: 36 year old male weighing 96.0 kg (211.2 pounds)

Reactions: Colorectal Cancer, Cerebral Haemorrhage

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Panitumumab
    Dosage: 6 mg/kg, q2wk
    Indication: Colorectal Cancer
    Start date: 2010-10-26
    End date: 2010-10-26

Warfarin
    Dosage: unk
    Administration route: Oral

Other drugs received by patient: Lobu; Ketoprofen; Lansoprazole; Depas