WARFARIN SUMMARY
WARFARIN SODIUM TABLETS, USP
Warfarin sodium is an anticoagulant which acts by inhibiting vitamin K-dependent coagulation factors.
Warfarin sodium tablets are indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, and pulmonary embolism.
Warfarin sodium tablets are indicated for the prophylaxis and/or treatment of the thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement.
Warfarin sodium tablets are indicated to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction.
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WARFARIN NEWS HIGHLIGHTS Media Articles Related to Warfarin
AHA: Home INR Monitoring for Warfarin Found Safe as Clinic Testing
Source: MedPage Today Neurology [2008.11.13]
Warfarin Underused in Atrial Fibrillation Patients
Source: MedicineNet Atrial Fibrillation Specialty [2008.10.15]
Warfarin Safer Than Heparin for Some Strokes
Source: MedicineNet enoxaparin Specialty [2008.07.15]
Joint Aspiration Safety With Coumadin (warfarin)
Source: MedicineNet Joint Aspiration Specialty [2003.01.20]
Aspirin as effective as warfarin and safer in stroke prevention
Source: The Doctors Lounge - Neurology
Published Studies Related to Warfarin
Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. [2008.08]
Aspirin, clopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too dangerous? [2008.06]
The role of cytochrome P2C19 in R-warfarin pharmacokinetics and its interaction with omeprazole. [2008.06]
Effect of ximelagatran and warfarin on stroke subtypes in atrial fibrillation. [2008.05]
CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study. [2008.03]
Clinical Trials Related to Warfarin
Duloxetine - Warfarin Pharmacodynamic Study [Completed]
Access II - Trial of Warfarin to Prevent Malfunction of Haemodialysis Catheters [Completed]
A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers [Completed]
Warfarin After Anterior ST-Elevation Myocardial Infarction [Completed]
Oral Vitamin K for Warfarin Associated Coagulopathy [Active, not recruiting]
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WARFARIN PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Warfarin has an overall score of 6. The effectiveness score is 8 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
| | Warfarin review by 44 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | heart condition |
| Dosage & duration: | | 3 mg. warfarin taken 1 time daily for the period of 3 years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Taking 3 mg of warfarin sufficiently thinned my blood so that I did not find it difficult to do everyday tasks. I immediately felt better after I started the regimen in the spring of 2003. My cough went away and I had a lot more energy.
I took this regimen for about 3 years, everyday. I also found it easier to concentrate and think (what was I doing before it???) It was as if my brain cleared up or something. I breathed easier and I was more willing to tackle regular household chores. I worked over 50 hours/week before and during this treatment. |
| Side effects: | | The side effects of warfarin on me did not become apparent until a couple of years later. I started feeling weak and I bruised easily. I acquired more broken blood vessels/capillaries veins in my feet and calves. I was tired and started feeling cranky. I stopped taking warfarin for 6 months but then went back to it after I had the old feeling of "thick" blood. During the 6 months that I wasn't taking warfarin, I felt better, had more energy. But then the downside: my blood was getting too thick and I was starting to get headaches. So I went back on it. This time my doctor said I might have to increase dosage to 4 mg. since I hadn't been taking the warfarin. However, when I had my thrombin checked, I was okay at 3 mg.; I took this for another 3 months and then started feeling the old way and quit again. The same scenario was repeated (started feeling like I had "thick" blood and now I had increasingly bad headaches). I went back on 3 mg. of warfarin in August of this year but only took them for 3 months. Then I started a vitamin/mineral/COQ10 regimen and stuck with it and am still doing that. I credit most of the perfect blood feeling (for lack of a better term) to Vitamin E and the fact that I also changed my diet. I try to eat a lot of veggies and fruits, and I have been a vegetarian for almost two years (not super strict - but I feel disgusted about eating meat and therefore never eat it unless it is buried in some food. I do eat salmon and tuna. The final straw for me with warfarin was that I started feeling really mad about things. The littlest things would make me angry, anger that was way out of proportion to the incident. When my teenaged daughter started crying after I ripped into her for staying longer at a social visit, and I heard my words echoing in my house, I knew that was it. I quit warfarin and started taking 81 mg. of aspirin daily (I had a headache every morning after I went off warfarin). I started the vit./min. regimen in November, gradually adding supplements as I learned about their benefits, but it wasn't until 3-4 weeks ago that I realized I wasn't having any headaches and I was able to stop taking 81 mg. of aspirin. Also, since starting the stricter diet and the vit./min. supplements (also some herbs), I have not had an anger "fit" (of course, I am also more prone to control my anger because I really didn't like how I had been), I do not feel depressed. I have told everyone in my family about this because it seems so remarkable. Why didn't the doctors tell me? |
| Comments: | | Treatment consisted of simply taking 3 mg. of warfarin daily and getting my blood thrombin checked every two months. I was not a very good patient about getting my blood thr. checked so I'm sure when I was feeling weak and bruised/bled so easily, my blood was getting too thin. And then when I would quit the warfarin for several weeks, sometimes months at a time, my blood would get too thick. I really like my doctor though, because he tells me to do what makes me feel best, and I think that's smart advice. I must say add that I always loved the feeling of donating blood before I took warfarin because it gave me the same feeling as I initially had with warfarin (at the very beginning of my treatment). I would like to donate blood now but they don't let me because I don't weigh enough (which makes no sense at all). Couldn't they take less blood? Who determined how much blood you can give anyway? |
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Page last updated: 2008-11-13
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