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Vytorin (Ezetimibe / Simvastatin) - Summary

 


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VYTORIN SUMMARY

VYTORIN contains ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor.

VYTORIN is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and to increase HDL-C in patients with primary (heterozygous familial and non- familial) hypercholesterolemia or mixed hyperlipidemia.

VYTORIN is indicated for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.

Therapy with lipid-altering agents should be a component of multiple risk-factor intervention in individuals at increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Lipid- altering agents should be used in addition to an appropriate diet (including restriction of saturated fat and cholesterol) and when the response to diet and other non-pharmacological measures has been inadequate.
See all Vytorin indications & dosage >>

VYTORIN NEWS HIGHLIGHTS

Media Articles Related to Vytorin (Ezetimibe / Simvastatin)

Justice Department Investigates Vytorin Marketing, More Lawsuits Face Merck, Schering
Source: Cholesterol News From Medical News Today [2008.11.06]

Is Vytorin Cancer Risk Real?
Source: MedicineNet ezetimibe Specialty [2008.08.25]

FDA to Explore Possible Vytorin-Cancer Link
Source: MedicineNet ezetimibe Specialty [2008.08.22]

Vytorin Fails to Lower Heart Valve Problems
Source: MedicineNet Aortic Stenosis Specialty [2008.07.22]

ezetimibe and simvastatin, Vytorin
Source: MedicineNet ezetimibe Specialty [2008.04.16]

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Published Studies Related to Vytorin (Ezetimibe / Simvastatin)

Effect of ezetimibe coadministration with simvastatin in a Middle Eastern population: a prospective, multicentre, randomized, double-blind, placebo-controlled trial. [2008.07]

Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men. [2008.05]

Lipid-altering efficacy and safety of ezetimibe/simvastatin coadministered with extended-release niacin in patients with type IIa or type IIb hyperlipidemia. [2008.04.22]

Simvastatin with or without ezetimibe in familial hypercholesterolemia. [2008.04.03]

Left atrial volume in patients with asymptomatic aortic valve stenosis (the Simvastatin and Ezetimibe in Aortic Stenosis study). [2008.04.01]

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Clinical Trials Related to Vytorin (Ezetimibe / Simvastatin)

Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2)(COMPLETED) [Completed]

Vytorin As Strategy To Reduce Dislipidemia In Adults [Completed]

IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome:Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (Study P04103) [Recruiting]

Clinical Trial of Zocor and Vytorin in Adolescents With Type 1 Diabetes [Recruiting]

Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-Density Lipoprotein (LDL) Cholesterol [Recruiting]

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VYTORIN PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Vytorin has an overall score of 3.75. The effectiveness score is 5 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Vytorin review by 51 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   cholesterol
Dosage & duration:   10/20 (dosage frequency: once a day) for the period of 2 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   significant reduction in cholesterol levels
Side effects:   none
Comments:   1 pill once a day

 

Vytorin review by 57 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   high cholesterol
Dosage & duration:   10/20 (dosage frequency: 1 day) for the period of 5 months
Other conditions:   Possible TIA 6 months before
Other drugs taken:   Dexedrine 20 mg
  
Reported Results
Benefits:   None. My LDL level did not drop.
Side effects:   My ck levels jumped to 480, bruising without trauma, loss of memory, lapses of time up to 4 hours, significant pain in legs which kept me awake at night, made my legs jump. My left leg contorted during a spasm, my foot turned out which couldn't be straigntened without help and masssge of the calf and foot.
Comments:   Cholesterol levels are high with genetic factors. LDL >170, HDL 80, total 276. The cardiologist used Vytorin as first and only treatment. My diet contained <20% fat intake, almost no saturated fat. I had pain in my legs within weeks, informed the doctor who checked my ck levels. Lab showed "within normal range" and I was told to resume the vytorin. Within 3 weeks the pain was unmanagable, so I called the doctor again. The nurse said I had to put up with a little discomfort but I insisted on another lab. Lab resulted in ck levels of 480, I was told to stop the vytorin and drink a lot of water. I changed cardiologist at that time.

 

Vytorin review by 57 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   high cholesterol
Dosage & duration:   10/20 (dosage frequency: 1 day) for the period of 5 months
Other conditions:   Possible TIA 6 months before
Other drugs taken:   Dexedrine 20 mg
  
Reported Results
Benefits:   None. My LDL level did not drop.
Side effects:   My ck levels jumped to 480, bruising without trauma, loss of memory, lapses of time up to 4 hours, significant pain in legs which kept me awake at night, made my legs jump. My left leg contorted during a spasm, my foot turned out which couldn't be straigntened without help and masssge of the calf and foot.
Comments:   Cholesterol levels are high with genetic factors. LDL >170, HDL 80, total 276. The cardiologist used Vytorin as first and only treatment. My diet contained <20% fat intake, almost no saturated fat. I had pain in my legs within weeks, informed the doctor who checked my ck levels. Lab showed "within normal range" and I was told to resume the vytorin. Within 3 weeks the pain was unmanagable, so I called the doctor again. The nurse said I had to put up with a little discomfort but I insisted on another lab. Lab resulted in ck levels of 480, I was told to stop the vytorin and drink a lot of water. I changed cardiologist at that time.

See all Vytorin reviews / ratings >>

Page last updated: 2008-11-06

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