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Nutrilib.com
A comprihensive source of nutritional information
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VYTORIN SUMMARY
VYTORIN contains ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor.
VYTORIN is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and to increase HDL-C in patients with primary (heterozygous familial and non- familial) hypercholesterolemia or mixed hyperlipidemia.
VYTORIN is indicated for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.
Therapy with lipid-altering agents should be a component of multiple risk-factor intervention in individuals at increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Lipid- altering agents should be used in addition to an appropriate diet (including restriction of saturated fat and cholesterol) and when the response to diet and other non-pharmacological measures has been inadequate.
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VYTORIN NEWS HIGHLIGHTS Media Articles Related to Vytorin (Ezetimibe / Simvastatin)
Justice Department Investigates Vytorin Marketing, More Lawsuits Face Merck, Schering
Source: Cholesterol News From Medical News Today [2008.11.06]
Is Vytorin Cancer Risk Real?
Source: MedicineNet ezetimibe Specialty [2008.08.25]
FDA to Explore Possible Vytorin-Cancer Link
Source: MedicineNet ezetimibe Specialty [2008.08.22]
Vytorin Fails to Lower Heart Valve Problems
Source: MedicineNet Aortic Stenosis Specialty [2008.07.22]
ezetimibe and simvastatin, Vytorin
Source: MedicineNet ezetimibe Specialty [2008.04.16]
Published Studies Related to Vytorin (Ezetimibe / Simvastatin)
Effect of ezetimibe coadministration with simvastatin in a Middle Eastern population: a prospective, multicentre, randomized, double-blind, placebo-controlled trial. [2008.07]
Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men. [2008.05]
Lipid-altering efficacy and safety of ezetimibe/simvastatin coadministered with extended-release niacin in patients with type IIa or type IIb hyperlipidemia. [2008.04.22]
Simvastatin with or without ezetimibe in familial hypercholesterolemia. [2008.04.03]
Left atrial volume in patients with asymptomatic aortic valve stenosis (the Simvastatin and Ezetimibe in Aortic Stenosis study). [2008.04.01]
Clinical Trials Related to Vytorin (Ezetimibe / Simvastatin)
Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2)(COMPLETED) [Completed]
Vytorin As Strategy To Reduce Dislipidemia In Adults [Completed]
IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome:Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (Study P04103) [Recruiting]
Clinical Trial of Zocor and Vytorin in Adolescents With Type 1 Diabetes [Recruiting]
Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-Density Lipoprotein (LDL) Cholesterol [Recruiting]
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VYTORIN PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 4 ratings/reviews, Vytorin has an overall score of 3.75. The effectiveness score is 5 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Vytorin review by 51 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | cholesterol |
| Dosage & duration: | | 10/20 (dosage frequency: once a day) for the period of 2 years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | significant reduction in cholesterol levels |
| Side effects: | | none |
| Comments: | | 1 pill once a day |
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| | Vytorin review by 57 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Ineffective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | high cholesterol |
| Dosage & duration: | | 10/20 (dosage frequency: 1 day) for the period of 5 months |
| Other conditions: | | Possible TIA 6 months before |
| Other drugs taken: | | Dexedrine 20 mg | | |
Reported Results |
| Benefits: | | None. My LDL level did not drop. |
| Side effects: | | My ck levels jumped to 480, bruising without trauma, loss of memory, lapses of time up to 4 hours, significant pain in legs which kept me awake at night, made my legs jump. My left leg contorted during a spasm, my foot turned out which couldn't be straigntened without help and masssge of the calf and foot. |
| Comments: | | Cholesterol levels are high with genetic factors. LDL >170, HDL 80, total 276. The cardiologist used Vytorin as first and only treatment. My diet contained <20% fat intake, almost no saturated fat. I had pain in my legs within weeks, informed the doctor who checked my ck levels. Lab showed "within normal range" and I was told to resume the vytorin. Within 3 weeks the pain was unmanagable, so I called the doctor again. The nurse said I had to put up with a little discomfort but I insisted on another lab. Lab resulted in ck levels of 480, I was told to stop the vytorin and drink a lot of water. I changed cardiologist at that time. |
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| | Vytorin review by 57 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | high cholesterol |
| Dosage & duration: | | 10/20 (dosage frequency: 1 day) for the period of 5 months |
| Other conditions: | | Possible TIA 6 months before |
| Other drugs taken: | | Dexedrine 20 mg | | |
Reported Results |
| Benefits: | | None. My LDL level did not drop. |
| Side effects: | | My ck levels jumped to 480, bruising without trauma, loss of memory, lapses of time up to 4 hours, significant pain in legs which kept me awake at night, made my legs jump. My left leg contorted during a spasm, my foot turned out which couldn't be straigntened without help and masssge of the calf and foot. |
| Comments: | | Cholesterol levels are high with genetic factors. LDL >170, HDL 80, total 276. The cardiologist used Vytorin as first and only treatment. My diet contained <20% fat intake, almost no saturated fat. I had pain in my legs within weeks, informed the doctor who checked my ck levels. Lab showed "within normal range" and I was told to resume the vytorin. Within 3 weeks the pain was unmanagable, so I called the doctor again. The nurse said I had to put up with a little discomfort but I insisted on another lab. Lab resulted in ck levels of 480, I was told to stop the vytorin and drink a lot of water. I changed cardiologist at that time. |
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Page last updated: 2008-11-06
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