Media Articles Related to Votrient (Pazopanib)
Gene expression profile may identify patients with renal cell carcinoma unlikely to benefit from nivolumab
Source: Urology / Nephrology News From Medical News Today [2016.08.08]
Renal cell carcinomas positive for the protein PD-L1 from patients who did not respond to treatment with the anti-PD-1 therapeutic nivolumab (Opdivo) had significantly higher expression of genes...
Published Studies Related to Votrient (Pazopanib)
An open-label extension study to evaluate safety and efficacy of pazopanib in
patients with advanced renal cell carcinoma. 
study (VEG105192/NCT00334282)... CONCLUSIONS: Efficacy and safety profiles for pazopanib in this extension study
Pazopanib versus sunitinib in metastatic renal-cell carcinoma. 
therapy... CONCLUSIONS: Pazopanib and sunitinib have similar efficacy, but the safety and
Modeling tumor growth kinetics after treatment with pazopanib or placebo in
patients with renal cell carcinoma. 
placebo and to identify predictive patient-specific covariates... CONCLUSIONS: Mathematical modeling of tumor growth kinetics can quantify the
A randomised, double-blind phase III study of pazopanib in patients with advanced
and/or metastatic renal cell carcinoma: final overall survival results and safety
updated safety results are now reported... INTERPRETATION: Although no significant difference in OS was observed in this
Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. [2011.06]
BACKGROUND & AIMS: Pazopanib has demonstrated clinical benefit in patients with advanced renal cell carcinoma (RCC) and is generally well tolerated. However, transaminase elevations have commonly been observed. This 2-stage study sought to identify genetic determinants of alanine transaminase (ALT) elevations in pazopanib-treated white patients with RCC... CONCLUSIONS: The rs2858996/rs707889 polymorphisms in the HFE gene may be associated with reversible ALT elevation in pazo-panib-treated patients with RCC. Copyright (c) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Clinical Trials Related to Votrient (Pazopanib)
PAZOFOS: Phase Ib and Phase II Trial of Pazopanib +/- Fosbretabulin in Advanced Recurrent Ovarian Cancer [Recruiting]
The first part of this study is to find the recommended dosages of a combination of two
drugs: pazopanib and fosbretabulin, which will be given to female patients with relapsed
The second part of the study involves comparing the recommended dose of pazopanib and
fosbretabulin in combination against pazopanib alone in female patients with relapsed
ovarian cancer to determine whether the combination is more beneficial that pazopanib on
A Phase 1B Dose-escalation and Phase 2a Study of TRC105 in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma [Recruiting]
The purpose of the phase 1b portion is to evaluate safety and tolerability and determine a
recommended phase 2 dose for TRC105 when added to standard dose pazopanib in patients with
advanced soft tissue sarcoma. Up to 18 patients will be treated.
The purpose of the phase 2 portion is to estimate the PFS of patients with advanced soft
tissue sarcoma by RECIST 1. 1 and estimate ORR in a separate cohort of patients with
angiosarcoma by RECIST 1. 1. Up to 76 patients will be treated in phase 2, including a cohort
of up to 13 patients with angiosarcoma.
Patient Preference Study of Pazopanib Versus Sunitinib in Advanced or Metastatic Kidney Cancer [Active, not recruiting]
This is a randomised, double-blind, cross-over study of pazopanib versus sunitinib in
patients with locally advanced or metastatic renal cell carcinoma (mRCC) who have received
no prior systemic therapy for advanced or metastatic RCC. Approximately 160 eligible
patients will be stratified based on the ECOG performance status (0 vs. 1) and number of
metastatic sites of disease (0 and 1 vs. >=2). The study consists of two treatment periods
of 10 weeks with a 2-week wash-out period between the two treatment periods. Patients will
receive pazopanib and sunitinib treatment sequentially in a double-blinded fashion. The
primary objective of the study is to assess how the tolerability and safety differences
between pazopanib and sunitinib translate into patient preference, defined by the patient's
stated preference for which drug they may prefer to continue treatment with at end of study.
The secondary objectives are to evaluate the reason for patient preference as assessed by a
patient preference questionnaire; to evaluate fatigue as assessed by FACIT-Fatigue and
quality of life as assessed by EuroQoL EQ-5D; to evaluate dose modifications and time to
dose modification; and to evaluate safety.
Phase II Study of the Optimal Scheme of Administration of Pazopanib in Thyroid Carcinoma [Recruiting]
The objective of this study is to determine the feasibility of pazopanib treatment
interruption with reintroduction at progression in iodine refractory progressive
Differentiated Thyroid Cancer (DTC) patients as compared to pazopanib continuous
Pazopanib or Pemetrexed and Crizotinib in Advanced Cancer [Recruiting]
The goal of this clinical research study is to find the highest tolerable dose of the
combination of Xalkori (crizotinib) either with Votrient (pazopanib) or Alimta (pemetrexed)
or of the combination of 3 study drugs that can be given to patients with advanced cancer.
The safety of these drug combinations will also be studied.
Crizotinib is designed to block a protein called ALK, which is involved in cancer cell
growth and survival.
Pazopanib is designed to block the growth of blood vessels that supply nutrients needed for
tumor growth. This may prevent or slow the growth of cancer cells.
Pemetrexed is designed to block proteins that may cause tumors to grow.
Reports of Suspected Votrient (Pazopanib) Side Effects
Decreased Appetite (52),
Drug Ineffective (48),
Blood Pressure Increased (36), more >>