Vontrol (Diphenidol) - Summary

VONTROL SUMMARY

VONTROL®
brand of
diphenidol
Antivertigo and antiemetic agent

Diphenidol, α, α-diphenyl-1-piperidinebutanol, is a compound not related to the antihistamines, phenothiazines, barbiturates, or other agents with antivertigo or antiemetic action. It has this configuration.

1. VERTIGO—‘Vontrol’ is indicated in peripheral (labyrinthine) vertigo and associated nausea and vomiting, as seen in such conditions as: Meniere’s disease, middle- and inner-ear surgery (labyrinthitis).
2. NAUSEA AND VOMITING—‘Vontrol’ is indicated in the control of nausea and vomiting, as seen in such conditions as: postoperative states, malignant neoplasms and labyrinthine disturbances.

NEWS HIGHLIGHTS

Published Studies Related to Vontrol (Diphenidol)

Diphenidol inhibited sodium currents and produced spinal anesthesia. [2010.06]
The aim of this study was to evaluate the effect of diphenidol on blocking Na(+) currents and spinal anesthesia.

Development of an HPLC method for determination of diphenidol in plasma and its application in an oral multi-dose bioequivalence study in a healthy female Mexican population. [2005.07.15]
Diphenidol was determined by an HPLC method developed in our laboratory. It was validated and proved to be linear in the 40-400 ng/ml range... These results suggest that the analytical method was linear, precise, and accurate for our purpose, and that both assayed formulations were bioequivalent.

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