Antivertigo and antiemetic agent
Diphenidol, α, α-diphenyl-1-piperidinebutanol, is a compound not related to the antihistamines, phenothiazines, barbiturates, or other agents with antivertigo or antiemetic action. It has this configuration.
- VERTIGO—‘Vontrol’ is indicated in peripheral (labyrinthine) vertigo and associated nausea and vomiting, as seen in such conditions as: Meniere’s disease, middle- and inner-ear surgery (labyrinthitis).
- NAUSEA AND VOMITING—‘Vontrol’ is indicated in the control of nausea and vomiting, as seen in such conditions as: postoperative states, malignant neoplasms and labyrinthine disturbances.
Published Studies Related to Vontrol (Diphenidol)
Diphenidol inhibited sodium currents and produced spinal anesthesia. [2010.06]
The aim of this study was to evaluate the effect of diphenidol on blocking Na(+) currents and spinal anesthesia.
Development of an HPLC method for determination of diphenidol in plasma and its application in an oral multi-dose bioequivalence study in a healthy female Mexican population. [2005.07.15]
Diphenidol was determined by an HPLC method developed in our laboratory. It was validated and proved to be linear in the 40-400 ng/ml range... These results suggest that the analytical method was linear, precise, and accurate for our purpose, and that both assayed formulations were bioequivalent.
Clinical Trials Related to Vontrol (Diphenidol)
Effect of Stellate Ganglion Block on Meniere's Disease [Completed]
Stellate ganglion block (SGB) has been the alternative treatment of Meniere's disease for
years. However, objective evidence of the effect of SGB was still lack. The investigators
conducted a randomized controlled study to examine the immediate effects of SGB in SP/AP of
Page last updated: 2010-10-05