NEWS HIGHLIGHTS
Published Studies Related to Voltaren-XR (Diclofenac Extended Release)
Economic analysis of celecoxib versus diclofenac plus omeprazole for the treatment of arthritis in patients at risk of ulcer disease. [2003.07.15]
AIM: To evaluate the economic impact of celecoxib therapy vs. diclofenac plus omeprazole therapy for the treatment of arthritis in Chinese patients with a high risk of bleeding, from the perspective of a public health organization in Hong Kong... CONCLUSIONS: Celecoxib therapy appears to cost less compared with diclofenac plus omeprazole for treatment of arthritis in Chinese patients with a high risk of bleeding.
Diclofenac reduces the incidence of acute pancreatitis after endoscopic retrograde cholangiopancreatography. [2003.06]
BACKGROUND & AIMS: Acute pancreatitis following endoscopic retrograde cholangiopancreatography presents a unique opportunity for prophylaxis and early modification of the disease process because the initial triggering event is temporally well defined and takes place in the hospital. We report a prospective, single-center, randomized, double-blind controlled trial to determine if rectal diclofenac reduces the incidence of pancreatitis following cholangiopancreatography... CONCLUSIONS: This trial shows that rectal diclofenac given immediately after endoscopic retrograde cholangiopancreatography can reduce the incidence of acute pancreatitis.
Preparation and in vitro-in vivo evaluation of double layer coated and matrix sustained release pellet formulations of diclofenac potassium. [2011.03.15]
The purpose of the present study was to prepare matrix extended release pellets of diclofenac potassium using low amount of release-modifying agents and, to compare its performance in vivo with coated pellets and matrix tablets. Coated pellets were prepared by extrusion-spheronization, followed by double layer coating using different polymers separately...
Application of design of experiments and multilayer perceptrons neural network in the optimization of diclofenac sodium extended release tablets with Carbopol 71G. [2010.07]
The purpose of the study was to screen the effects of formulation factors on the in vitro release profile of diclofenac sodium from matrix tablets using design of experiment (DOE). Formulations of diclofenac sodium tablets, with Carbopol 71G as matrix substance, were optimized by artificial neural network...
Diclofenac-loaded biopolymeric nanosuspensions for ophthalmic application. [2009.03]
Polymeric nanoparticle suspensions (NS) were prepared from poly(lactide-co-glycolide) and poly(lactide-co-glycolide-leucine) {poly[Lac(Glc-Leu)]} biodegradable polymers and loaded with diclofenac sodium (DS), with the aim of improving the ocular availability of the drug...
Clinical Trials Related to Voltaren-XR (Diclofenac Extended Release)
Study to Compare the Pharmacokinetics of IV Diclofenac Sodium (2 Doses)Versus Oral Diclofenac Potassium [Completed]
The purpose of this study is to assess the pharmacokinetic parameters of intravenous
diclofenac sodium (DIC075V) 18. 75 mg and 37. 5 mg following single- and multiple-dose
administration, as compared to oral diclofenac potassium (Cataflam® 50 mg), the approved
reference product.
Assess Platelet Function and Safety After Administration of Injectable Diclofenac Compared to Ketorolac and Aspirin in Adult Male Volunteers [Completed]
This study will assess platelet function and safety in healthy male volunteers following
doses of intravenous diclofenac compared to cataflam, intravenous ketorolac and aspirin.
A Study Comparing Diclofenac Sodium Gel 3% to Solaraze� Gel 3% in the Treatment of Actinic Keratosis [Recruiting]
The objective of this study is to compare the relative efficacy and safety of the test
formulation diclofenac sodium gel 3% (Taro Pharmaceuticals Inc.) to the marketed formulation
Solaraze® (diclofenac sodium) Gel 3% (Fougera Pharms) in the treatment of actinic keratosis.
Both the test and reference formulations will also be compared to a placebo formulation to
test for superiority.
A Clinical Study in Healthy Male Volunteers to Compare the Bioequivalence of Fixed Dose Combination of Eperisone Hydrochloride 50mg Plus Diclofenac Sodium 50mg as Capsule With Eperisone Hydrochloride 50mg and Diclofenac Sodium 50mg Tablets Under Fasting Conditions [Recruiting]
The primary objective of this study is to compare the bioavailabilities of a single fixed
dose combination of eperisone 50 mg plus diclofenac 50 mg capsules with the
bioavailabilities of eperisone 50 mg tablets and diclofenac 50 mg tablets in healthy human
adult male subjects under fasting conditions.
Effects of Pennsaid on Clinical Neuropathic Pain [Recruiting]
The purpose of this study is to see if the drug Pennsaid (Diclofenac) can help reduce pain
felt by people with chronic nerve pain. The drug will be used 2-4 times each day for 2
weeks.
The U. S. Food and Drug Administration (FDA) has approved Pennsaid to treat osteoarthritis
(bone pain), but the FDA has not approved Pennsaid to treat neuropathic (nerve) pain.
The research study will compare Pennsaid to placebo.
Reports of Suspected Voltaren-XR (Diclofenac Extended Release) Side Effects
Rectal Perforation (3),
Blood Pressure Increased (3),
Vomiting (3),
Muscular Weakness (3),
Thrombosis (2),
Drug Ineffective (2),
Diverticulitis (2),
Therapeutic Response Unexpected (2),
Fatigue (2),
Overdose (2), more >>
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