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Vivitrol (Naltrexone) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

Patients taking VIVITROL may not benefit from opioid-containing medicines. Naltrexone antagonizes the effects of opioid-containing medicines, such as cough and cold remedies, antidiarrheal preparations and opioid analgesics.

OVERDOSAGE

There is limited experience with overdose of VIVITROL. Single doses up to 784 mg were administered to 5 healthy subjects. There were no serious or severe adverse events. The most common effects were injection site reactions, nausea, abdominal pain, somnolence, and dizziness. There were no significant increases in hepatic enzymes.

In the event of an overdose, appropriate supportive treatment should be initiated.

CONTRAINDICATIONS

VIVITROL is contraindicated in:

  • Patients receiving opioid analgesics [see Warnings and Precautions ].
  • Patients with current physiologic opioid dependence [see Warnings and Precautions].
  • Patients in acute opioid withdrawal [see Warnings and Precautions ].
  • Any individual who has failed the naloxone challenge test or has a positive urine screen for opioids [see Warnings and Precautions].
  • Patients who have previously exhibited hypersensitivity to naltrexone, PLG, carboxymethylcellulose, or any other components of the diluent [see Warnings and Precautions].

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