ADVERSE REACTIONS
The most frequently reported adverse experiences have been local injection site reactions. Hyaluronidase has been reported to enhance the adverse events associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis. Allergic reactions (urticaria, angioedema) have been reported in less than 0.1% of patients receiving hysluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.
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