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Vitrase (Hyaluronidase, Ovine) - Summary

 
 



VITRASE SUMMARY

VITRASEĀ is a preparation of purified ovine testicular hyaluronidase, a protein enzyme. The exact chemical structure of this enzyme is unknown.
VITRASEĀ (hyaluronidase injection) is supplied as a sterile, non-preserved, colorless solution with a pH of 6.4 to 7.2. Each mL contains 200 USP units of ovine hyaluronidase with 0.93 mg lactose, 0.36 mg potassium phosphate dibasic, 0.23 mg potassium phosphate monobasic, and 9.0 mg sodium chloride.

Subcutaneous Fluid Administration

VITRASE (hyaluronidase injection) is indicated as an adjuvant in subcutaneous fluid administration for achieving hydration.

Dispersion and Absorption of Injected Drugs

VITRASE is indicated as an adjuvant to increase dispersion and absorption of other injected drugs.

Subcutaneous Urography

VITRASE is indicated as an adjuvant in subcutaneous urography for improving resorption of radiopaque agents.


See all Vitrase indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Vitrase (Hyaluronidase)

Advances in Companion Diagnostics Congress - Pre-Congress Live Webinars: Register For Free
Source: Conferences News From Medical News Today [2017.02.10]
Pre-Congress Live Webinars: Register For Free 'Challenges in Developing Companion Diagnostics for Cancer and Immunology'Tuesday 14th February - 3.00 pm GMTCan't make the date?

Flexible future of point-of-care disease diagnostic
Source: Bird Flu / Avian Flu News From Medical News Today [2015.07.29]
The world-wide deployment of biomedical devices for health monitoring, point-of-care diagnostics and environmental sensing is hampered by their high cost that is not readily affordable for e.g.

Myelopathy: Chameleons and Mimics
Source: Medscape Orthopaedics Headlines [2017.02.16]
Myelopathies can be challenging to diagnose, and non-myelopathic disease can mimic a cord lesion--resulting in misdiagnosis and potentially dangerous delay. Review diagnostic pearls in this primer.
Practical Neurology

New Insights Into Liver Disease and Transplantation
Source: Medscape Gastroenterology Headlines [2017.02.13]
Findings on new therapeutic options, long-term outcomes, and diagnostic tools were on view at the recent Liver Meeting. Dr William Balistreri reports what you need to know most.
Medscape Gastroenterology

Clinical Insights Into Gastrointestinal Stromal Tumours
Source: Medscape Radiology Headlines [2017.02.13]
Is surgery alone a curative treatment for gastrointestinal stromal tumours? This study examined the treatment outcomes of GISTs, highlighting some of the diagnostic and therapeutic challenges.
Frontline Gastroenterology

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Published Studies Related to Vitrase (Hyaluronidase)

Adjuvant hyaluronidase to epidural steroid improves the quality of analgesia in failed back surgery syndrome: a prospective randomized clinical trial. [2014]
STUDY DESIGN: Prospective randomized trial... CONCLUSION: We conclude that adding hyaluronidase to the epidural injectate was

Predicting response of vitreous hemorrhage after intravitreous injection of highly purified ovine hyaluronidase (Vitrase) in patients with diabetes. [2008.10]
PURPOSE: To develop a predictive model for patients with diabetes who are most likely to have vitreous hemorrhage clearing by 3 months after a single, intravitreous injection of highly purified, preservative-free, ovine hyaluronidase (Vitrase; ISTA Pharmaceuticals, Inc., Irvine, CA)...

Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage. [2005.10]
PURPOSE: To evaluate the safety of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage. DESIGN: Two prospective, randomized, placebo-controlled, double-masked studies. Pooled efficacy data are presented in a companion article in this issue of The Journal... CONCLUSIONS: No serious safety issues were reported after a single intravitreous injection of ovine hyaluronidase. RD incidence was not statistically different between groups. Iritis manifesting as an acute self limited inflammation was the most common adverse event, occurred in a dose response fashion, but was not noted to result in a serious adverse event in any hyaluronidase treated eye.

Hyaluronidase for reducing perineal trauma. [2014]
CONCLUSIONS: Perineal HAase injection during second stage of labour had

Tolerability and pharmacokinetic properties of ondansetron administered subcutaneously with recombinant human hyaluronidase in minipigs and healthy volunteers. [2014]
ondansetron monotherapy in healthy volunteers... CONCLUSIONS: Subcutaneous ondansetron + rHuPH20 was generally well-tolerated.

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Clinical Trials Related to Vitrase (Hyaluronidase)

Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage [Completed]

Evaluation of Vitrase as a Spreading Agent [Completed]
The purpose of this study is to determine whether Vitrase (hyaluronidase for injection) is effective as a spreading agent for other injected drugs prior to ocular surgery

Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase) [Completed]
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity to Vitrase following a single intradermal injection of 3 USP units Vitrase. Less than or equal to 10% hypersensitivity response was considered acceptable.

Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase) [Completed]
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity to Vitrase following a single intradermal injection of 3 USP units Vitrase. Less than or equal to a 10% hypersensitivity response was considered acceptable.

Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment [Completed]
The purpose of this study is to assess the efficacy of intravitreous injections of Vitrase to induce posterior vitreous detachment(PVD) in subjects with moderate to severe non-proliferative diabetic retinopathy.

more trials >>


Page last updated: 2017-02-16

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