NEWS HIGHLIGHTS
Published Studies Related to Vistaril (Hydroxyzine)
Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments. [2008.12]
Peripheral anti-H1 and central nervous system (CNS) activities after single (day 1) and repeated (day 7) administrations of increasing doses of bilastine (BIL) were assessed in 20 healthy volunteers throughout a crossover, randomized, double-blind, placebo (PLA)-controlled study... The 40-mg dose of BIL produced subjective report of sedation, whereas unwanted objective CNS side effects were observed only with the 80-mg dose.
Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. [2008.12]
Pharmacokinetic parameters of hydroxyzine and its active metabolite cetirizine were determined after oral and intravenous administration of 2 mg kg(-1) of hydroxyzine to six healthy dogs. Plasma drug levels were determined with high-pressure liquid chromatography... Pharmacodynamic modelling predicted that maximal antihistamine effect would occur with twice daily oral administration of hydroxyzine at 2 mg kg(-1).
Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial. [2007.04]
OBJECTIVES: Sleep difficulty is common in minimal hepatic encephalopathy (HE) and the mechanisms are not fully elucidated. Dysregulated histamine neurotransmission is associated with an altered circadian rhythmicity that is partially restored following central histamine H1 receptor blockade in cirrhotic animals. We studied the effects of the histamine H1 blocker hydroxyzine in sleep alterations in patients with cirrhosis in a double-blind, randomized controlled fashion... CONCLUSIONS: In contrast to placebo, hydroxyzine 25 mg at bedtime improved sleep behavior (subjectively and using wrist actigraphy) in patients with cirrhosis and minimal HE. The risk of precipitating overt HE warrants some caution when prescribing this drug.
[Hydroxyzine premedication does not alter bispectral index changes following etomidate induction of general anaesthesia] [2007.03]
OBJECTIVE: Various drugs including hydroxyzine are preoperatively administered to facilitate the induction of general anaesthesia. We investigated the effect of hydroxyzine premedication on BIS-based etomidate induction of general anaesthesia... CONCLUSION: Oral weight-related hydroxyzine premedication does not alter BIS-based etomidate induction of GA.
Histamine H1 Blocker Hydroxyzine Improves Sleep in Patients With Cirrhosis and Minimal Hepatic Encephalopathy: A Randomized Controlled Pilot Trial. [2007.01.11]
OBJECTIVES: Sleep difficulty is common in minimal hepatic encephalopathy (HE) and the mechanisms are not fully elucidated. Dysregulated histamine neurotransmission is associated with an altered circadian rhythmicity that is partially restored following central histamine H1 receptor blockade in cirrhotic animals. We studied the effects of the histamine H1 blocker hydroxyzine in sleep alterations in patients with cirrhosis in a double-blind, randomized controlled fashion... CONCLUSIONS: In contrast to placebo, hydroxyzine 25 mg at bedtime improved sleep behavior (subjectively and using wrist actigraphy) in patients with cirrhosis and minimal HE. The risk of precipitating overt HE warrants some caution when prescribing this drug. (Am J Gastroenterol 2007;102:1-10).
Clinical Trials Related to Vistaril (Hydroxyzine)
Comparative Effects of Rupatadine 10 mg, Hydroxyzine 50 mg and Placebo on Actual Driving Performance [Terminated]
The primary objective of this study is to measure and compare the acute effects of rupatadine
10 mg, relative to placebo and hydroxyzine 50 mg as an active control on healthy volunteers’
performance on a standard over-the-road driving test and a car-following test.
A Bioequivalence Study of Docetaxel for Injectable Emulsion (ANX-514) in Patients With Advanced Cancer [Recruiting]
The purpose of this study is to compare an injectable emulsion form of docetaxel to Taxotere
in patients with advanced cancer.
POWS: Palonosetron/Ondansetron Opioid Withdrawal Study [Recruiting]
Opioid medications are commonly used for pain relief. When given over time, physical
dependence can occur. This results in unpleasant side effects--such as agitation and
nausea--if opioid medications are suddenly stopped. We are interested in knowing if a
medication named Ondansetron can help ease or prevent symptoms associated with opioid
withdrawal. We are also interested in knowing if a similar (but more potent FDA-approved
drug, palonosetron) can more effectively treat withdrawal symptoms with or without
combination with an antihistamine called hydroxyzine (vistaril).
The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction [Not yet recruiting]
The purpose of this study is to measure the prevalence and severity of cardiac autonomic
neuropathy (CAN), diabetic autonomic neuropathy (DAN) which in non-diabetics is termed
advanced nervous system (ANS) dysfunction, and autonomic dysfunction as well as the overall
sympathovagal balance (SB) in the CEFH population of diabetic patients versus non-diabetic
patients undergoing elective vitreoretinal surgery.
A Bioequivalence Study of Vinorelbine Tartrate Injectable Emulsion in Patients With Advanced Cancer. [Completed]
This study is a randomized, single dose crossover comparison of the investigational product
with a Reference Product (vinorelbine tartrate injection, NAVELBINE®). The primary objective
is to demonstrate the equivalence of ANX-530 and the Reference Product, NAVELBINE.
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