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Vistaril (Hydroxyzine Pamoate) - Summary



VISTARIL (Hydroxyzine pamoate) is an antihistamine with sedative properties.

VISTARIL (HYDROXYZINE) is indicated for the following:

Hydroxyzine may potentiate meperidine (Demerol®) and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent.

The effectiveness of hydroxyzine as an antianxiety agent for long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient.


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Published Studies Related to Vistaril (Hydroxyzine)

Efficacy of dimetinden and hydroxyzine/chlorpheniramine in atopic dogs: a randomised, controlled, double-blinded trial. [2013]
Antihistaminic drugs are commonly used as symptomatic therapy of atopic dermatitis in dogs...

A preliminary randomised double-blind placebo-controlled clinical trial of hydroxyzine for treating sleep bruxism in children. [2013]
This is a randomised placebo-controlled clinical trial investigating the efficacy of hydroxyzine for treating parent-reported sleep bruxism in children. Participants of this trial were 30 patients randomly allocated to one of the two groups in a ratio of 1:2... Current evidence support that hydroxyzine is effective and well tolerated for treating bruxism in children.

Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers. [2011.06]
It is well known that the sedative properties of antihistamines can differ considerably between individual drugs... It is concluded that hydroxyzine-induced impairment at tmax is more prominent after morning doses compared with evening doses and that the present study could not present direct evidence to substantiate the hypothesis that histamine availability inversely affects the magnitude of antihistamine impairment.

[Effects of hydroxyzine on tolerance of facial mask during induction in children] [2010.01]
OBJECTIVE: To evaluate the effectiveness of hydroxyzine as a premedication agent for the acceptance of facial mask during induction of general anaesthesia in children... CONCLUSION: Hydroxyzine provided better acceptance of facial mask than placebo during induction of general anaesthesia in children. Copyright 2009 Elsevier Masson SAS. All rights reserved.

Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments. [2008.12]
Peripheral anti-H1 and central nervous system (CNS) activities after single (day 1) and repeated (day 7) administrations of increasing doses of bilastine (BIL) were assessed in 20 healthy volunteers throughout a crossover, randomized, double-blind, placebo (PLA)-controlled study... The 40-mg dose of BIL produced subjective report of sedation, whereas unwanted objective CNS side effects were observed only with the 80-mg dose.

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Clinical Trials Related to Vistaril (Hydroxyzine)

Levocetirizine Plus Bed-Time Hydroxyzine in the Management of Corticodependent Chronic Urticaria Versus Both Drugs Alone in High Doses [Recruiting]
Allen Kaplan is a prominent American allergist with the reputation of leader in the field of chronic urticaria. He advocates treatment with first generation hydroxyzine, which he considers at least as effective as modern second generation H1-blockers in suppressing the symptoms of difficult-to-treat / systemic-steroid-dependant cases of chronic urticaria. He further speculates that hydroxyzine may have the advantage to better suppress itch and improve nighttime sleep. This has prompted many practitioners around the world to believe that adding hydroxyzine to the treatment regimen at bed time at night may be beneficial to patients. At the same time European guidelines indicate modern second generation H1-blockers in higher than conventional doses as drugs of choice for such cases. However, there is no evidence from clinical trials addressing this controversy. The investigators' previous studies suggest that levocetirizine at quadruple doses may be beneficial in difficult to treat urticaria by reducing lesions and itch, improving quality of life and night time sleep, while not causing day time somnolence. First generation H1-receptor antagonists and hydroxyzine among them are known to penetrate the blood / brain barrier and to cause sedation. The question stays whether this sedation is beneficial to the subjects with chronic urticaria at night, whether it has any hang-over unwanted effects the following day and whether this has any influence on the overall urticaria-specific quality of life.

Does Hydroxyzine Decrease Anxiety in Patients With Anorexia Nervosa Study [Not yet recruiting]
The purpose of this study is to determine the effectiveness of hydroxyzine in the treatment of meal-related anxiety in children and adolescents 8 to 17 years of age diagnosed with anorexia nervosa. The investigators want to find out if hydroxyzine given before meals will improve meal-related anxiety compared to no hydroxyzine.

Pain and Anxiety Management of Traumatic Emergency in a Pre-hospital Setting [Recruiting]
Unexpected acute pain in an emergency setting causes anxiety, insecurity, and stress that can diminish perceptions of control over pain and diminish ability to decrease pain. This may interfere with the opioid treatment and poses the question of whether an anxiolytic drug added to the morphine titration could relief pain and/or anxiety. This randomized double-blind group clinical trial is designed to determine the efficacy and safety of hydroxyzine in addition to a conventional intravenous morphine titration protocol.

Comparative Effects of Rupatadine 10 mg, Hydroxyzine 50 mg and Placebo on Actual Driving Performance [Terminated]
The primary objective of this study is to measure and compare the acute effects of rupatadine 10 mg, relative to placebo and hydroxyzine 50 mg as an active control on healthy volunteers’ performance on a standard over-the-road driving test and a car-following test.

A Bioequivalence Study of Docetaxel for Injectable Emulsion (ANX-514) in Patients With Advanced Cancer [Recruiting]
The purpose of this study is to compare an injectable emulsion form of docetaxel to Taxotere in patients with advanced cancer.

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Reports of Suspected Vistaril (Hydroxyzine) Side Effects

Drug Ineffective (21)Depression (19)Anxiety (17)Fall (15)Emotional Disorder (15)Somnolence (12)Pain in Extremity (12)Suicide Attempt (10)Gait Disturbance (10)Hypertension (10)more >>


Based on a total of 1 ratings/reviews, Vistaril has an overall score of 1. The effectiveness score is 2 and the side effect score is 4. The scores are on ten point scale: 10 - best, 1 - worst.

Vistaril review by 24 year old female patient

Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   Anxiety
Dosage & duration:   25mg taken every six hours for the period of 3 months
Other conditions:   anxiety
Other drugs taken:   CLONAZEPAM
Reported Results
Benefits:   I suffer from an anxiety disorder and have tried several medications. So far Clonazepam has helped me the best.
Side effects:   I would have anxiety attacts more often on Vistaril then any other medications. I have had no side effects from Clonazepam.
Comments:   I take the medication three times daily and I see a doctor once a week to see how I am doind as far as medications and to get therapy.

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Page last updated: 2014-11-30

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