NEWS HIGHLIGHTSMedia Articles Related to Visken (Pindolol)
Isolated Systolic Hypertension in Young Adults Ups CVD Risk
Source: theheart.org | Medscape Cardiology Headlines [2015.01.30]
In younger and middle-aged adults, isolated systolic hypertension is not "benign," as many may have thought until now, new research shows.
Heartwire
New hypertension guidelines could save lives and money
Source: Hypertension News From Medical News Today [2015.01.30]
Increased treatment of severe hypertension particularly cost-effectiveFull implementation of new hypertension guidelines could prevent 56,000 cardiovascular disease events (mostly heart attacks...
Looser Hypertension Guidelines Could Still Save Lives, $$ (CME/CE)
Source: MedPage Today Cardiovascular [2015.01.30]
(MedPage Today) -- Even the less aggressive 2014 targets would be better than the status quo, study shows.
Alcohol Boosts Stroke Risk More Than Do Hypertension, Diabetes
Source: Medscape NeurologyHeadlines [2015.01.29]
Consuming more than two alcoholic drinks a day was a stronger predictor of stroke in early old age than were the traditional risk factors of hypertension or diabetes.
Medscape Medical News
Insomnia With Daytime Hyperarousal Linked to Hypertension
Source: Medscape NeurologyHeadlines [2015.01.29]
Researchers report further evidence that insomnia itself, without sleep apnea, is associated with the development of hypertension.
Medscape Medical News
Published Studies Related to Visken (Pindolol)
Can we really accelerate and enhance the selective serotonin reuptake inhibitor antidepressant effect? A randomized clinical trial and a meta-analysis of pindolol in nonresistant depression. [2011.07]
CONCLUSIONS: Present findings represent further evidence of the acceleration and enhancement of efficacy with pindolol administered together with SSRIs, displaying a quicker and more pronounced decrease of symptoms in patients with nonresistant major depressive disorder. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00931775. (c) Copyright 2011 Physicians Postgraduate Press, Inc.
Pindolol augmentation enhances response outcomes in first depressive episodes. [2009.07]
Effectiveness of Pindolol addition to SSRIs is still a matter of debate.
Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs. [2009.01]
OBJECTIVE: To compare the effects of morphine, parecoxib, tramadol and a combination of parecoxib, tramadol and pindolol on nociceptive thresholds in awake animals and their effect on glomerular filtration rate (GFR) in dogs subjected to 30 minutes of anesthesia. ANIMALS: Eight adult mixed breed experimental dogs. STUDY DESIGN: Randomized, controlled trial... CONCLUSION: Tramadol and parecoxib (either alone or in combination) can increase nociceptive thresholds in awake dogs and have minimal effects on renal perfusion in normotensive dogs subjected to anaesthesia.
Paroxetine with pindolol augmentation: A double-blind, randomized, placebo-controlled study in depressed in-patients. [2008.02]
Pindolol, a 5-HT1A autoreceptor antagonist, given in combination with selective serotonin reuptake inhibitors (SSRIs), may enhance and/or accelerate the therapeutic efficacy of SSRIs. Fifty patients, meeting ICD-10 criteria for major depressive disorder or bipolar depression, were enrolled in our randomized, placebo-controlled, double-blind trial...
Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients. [2004.06]
Loss of noradrenergic (NE) neurones in the locus ceruleus and compensatory changes in NE activity have been described in Alzheimer's disease (AD), but have never been linked to treatment. The hypothesis of this study was that central NE responsivity would predict aggression response to treatment with a NE medication, pindolol...
Clinical Trials Related to Visken (Pindolol)
Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression [Terminated]
This study investigates the hypothesis that pindolol can accelerate the response to
antidepressants in patients with major depression treated with venlafaxine.
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors [Recruiting]
The serotonin 2A (5-HT2A) receptor is the most abundant excitatory serotonin (5-HT,
5-hydroxytryptamine) receptor in the human brain, and multiple positron emission tomography
(PET) studies have investigated the 5-HT2A receptors in the human brain using antagonist
radioligands. However, the currently available antagonist PET radioligands bind the total
pool of 5-HT2A receptor receptors whereas a 5-HT2A receptor agonist binds the high-affinity
subgroup of the receptors which are also G-protein coupled, and thus hypothesized to be the
functional relevant population of receptors. At the Center for Integrated Molecular Brain
Imaging (CIMBI), a novel agonist PET radioligands for brain imaging of 5-HT2A receptors was
recently validated in animals (Ettrup et al. 2011, EJNMMI). In the human brain,
[11C]Cimbi-36 was validated as a selective 5-HT2A receptor agonist PET radioligand through a
blocking study with the 5-HT2A receptor antagonist pharmaceutical ketanserin. In this
validation study, the biodistribution and kinetic modelling of [11C]Cimbi-36 binding in the
human brain was also validated. With these studies, investigators will test the most
promising of these, [11C]Cimbi-36, in clinical trials, where it will provide a novel method
for detecting dysfunction in the 5-HT system. The specific aim of this clinical trial is:
- To examine the effect of acute alterations in 5-HT levels on cerebral [11C]Cimbi-36
binding in healthy volunteers who will be PET-scanned at baseline and after pharmacological
or dietary interventions that either increase or decrease cerebral 5-HT levels.
It is hypothesized that this novel agonist radioligand will provide both a more
physiological relevant measure of the 5-HT2A receptors and also reflect levels of cerebral
5-HT in humans, more specifically:
BP will decrease after pindolol and selective serotonin reuptake inhibitor (SSRI) treatment
and increase after acute tryptophan depletion (ATD). Placebo will leave binding potential
(BP) unchanged.
EScitalopram PIndolol ONset of Action [Recruiting]
The main purpose of this study is to determine whether the antidepressant response of
escitalopram 30mg/day or escitalopram 20mg/day + pindolol, a beta blocker, is different
(faster) compared to a standard dose of escitalopram 20mg/day.
Comparison of the Pharmacokinetics of Three Generic Medications and Their Respective Brand Preparations [Recruiting]
Generic describes a pharmaceutical product that does not have a brand name or trademark.
Generic medications should be the equivalent of brand medications. Only their price should
be different. The active ingredient of the generic medication has to be within a window of
80 to 125% of the original in the blood. There are reports that this standard is not always
followed after the medication has been on the market. Indeed, it was observed that some
patients previously stable on original medications relapsed when switched to a generic.
Several factors could account for this problem. Such problems have been reported for
Pindolol, Quetiapine, and Trazodone. Some properties of specific brands of the generics and
the original brands will be examined for these three medications. The three original
medications used in this study are the Visken, the Seroquel, and the Desyrel. The three
generics are the Teva-pindolol, the Teva-Quetiapine, and the Teva-Trazodone. They are all
available on the Canadian market by prescription.
Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris [Recruiting]
The purpose of this study is to determine if long-term vasodilatory treatment is more
effective than the standard treatment in hypertensive patients with microvascular angina
pectoris
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