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Vioxx (Rofecoxib) - Published Studies


Vioxx Related Published Studies

Well-designed clinical trials related to Vioxx (Rofecoxib)

Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer: final results of the VICTOR trial. [2010.10.20]

Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer: final results of the VICTOR trial. [2010]

Pooled analysis of rofecoxib placebo-controlled clinical trial data: lessons for postmarket pharmaceutical safety surveillance. [2009.11.23]

Evaluation and management of post-shock wave lithotripsy pain with third-generation lithotriptors using rofecoxib. [2009.03]

Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. [2008.11.15]

Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE*3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban). [2008.08.01]

Was the thrombotic risk of rofecoxib predictible from the French Pharmacovigilance Database before 30 September 2004? [2008.08]

The effects of preoperative rofecoxib, metoclopramide, dexamethasone, and ondansetron on postoperative pain and nausea in patients undergoing elective laparoscopic cholecystectomy. [2007.10]

The VIOXX in Prostate Cancer Prevention study: cardiovascular events observed in the rofecoxib 25 mg and placebo treatment groups. [2007.09]

The prolonged postoperative analgesic effect when dexamethasone is added to a nonsteroidal antiinflammatory drug (rofecoxib) before breast surgery. [2007.08]

The prolonged postoperative analgesic effect when dexamethasone is added to a nonsteroidal antiinflammatory drug (rofecoxib) before breast surgery. [2007.08]

Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer. [2007.07.26]

Factorial phase III randomised trial of rofecoxib and prolonged constant infusion of gemcitabine in advanced non-small-cell lung cancer: the GEmcitabine-COxib in NSCLC (GECO) study. [2007.06]

Octreotide alone or in combination with rofecoxib as palliative treatment for advanced hepatocellular cancer. [2007.05]

Short-Term Efficacy of Rofecoxib and Diclofenac in Acute Shoulder Pain: A Placebo-Controlled Randomized Trial. [2007.03.09]

Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. [2007.03]

Adjusted indirect comparison of celecoxib versus rofecoxib on cardiovascular risk. [2007.03]

Similar effects of rofecoxib and indomethacin on the incidence of heterotopic ossification after hip arthroplasty. [2007.02]

Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial. [2007.02]

A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. [2006.12]

Peptic Ulcer and Bleeding Events Associated With Rofecoxib in a 3-Year Colorectal Adenoma Chemoprevention Trial. [2006.11.10]

Divergent effects of rofecoxib on endothelial function and inflammation in acute coronary syndromes. [2006.10.10]

Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery. [2006.09]

Analgesic efficacy of the cyclooxygenase-inhibiting nitric oxide donor AZD3582 in postoperative dental pain: Comparison with naproxen and rofecoxib in two randomized, double-blind, placebo-controlled studies. [2006.09]

Effects of long-term rofecoxib on gastric intestinal metaplasia: results of a randomized controlled trial. [2006.08.01]

Patient retention in a clinical trial: a lesson from the rofecoxib (VIOXX) study. [2006.07]

Rofecoxib 12.5 mg, rofecoxib 25 mg, and celecoxib 200 mg in the treatment of symptomatic osteoarthritis: results of two similarly designed studies. [2006.07]

Rofecoxib 50 mg and valdecoxib 20 or 40 mg in adults and adolescents with postoperative pain after third molar extraction: results of two randomized, double-blind, placebo-controlled, single-dose studies. [2006.07]

Evaluation of the comparative efficacy and tolerability of rofecoxib and naproxen in children and adolescents with juvenile rheumatoid arthritis: a 12-week randomized controlled clinical trial with a 52-week open-label extension. [2006.05]

The effects of esomeprazole combined with aspirin or rofecoxib on prostaglandin E2 production in patients with Barrett's oesophagus. [2006.04.01]

The cyclooxygenase-2 inhibitor rofecoxib (Vioxx) in the treatment of cervical dysplasia grade II-III A phase II trial. [2006.04.01]

Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery. [2006.04]

Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. [2006.04]

Comparison of adjunctive use of rofecoxib versus ibuprofen in the management of postoperative pain after uterine artery embolization. [2006.04]

A randomized, double-blind, placebo-controlled trial of a COX-2 inhibitor (Rofecoxib) in patients undergoing coronary artery bypass surgery. [2006.04]

Does perioperative administration of rofecoxib improve analgesia after spine, breast and orthopaedic surgery? [2006.03]

Preoperative administration of rofecoxib versus ketoprofen for pain relief after tonsillectomy. [2006.03]

Evaluation of the effect of perioperative rofecoxib treatment on pain control and clinical outcomes in patients recovering from gynecologic abdominal surgery: a randomized, double-blind, placebo-controlled clinical study. [2006.03]

Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial. [2006.02]

Treatment of patients with osteoarthritis with rofecoxib compared with nabumetone. [2006.02]

Nasal and bronchial tolerability of Rofecoxib in patients with aspirin induced asthma. [2006.01]

Comparison of the COX-inhibiting nitric oxide donator AZD3582 and rofecoxib in treating the signs and symptoms of Osteoarthritis of the knee. [2005.12.15]

Prospective randomized, double-blinded, placebo-controlled trial of preoperative rofecoxib for pain relief in uterine curettage. [2005.12]

Rofecoxib and tramadol do not attenuate delayed-onset muscle soreness or ischaemic pain in human volunteers. [2005.12]

The efficacy of preoperative versus postoperative rofecoxib for preventing acute postoperative dental pain: a prospective randomized crossover study using bilateral symmetrical oral surgery. [2005.11]

A randomized, placebo-controlled study of rofecoxib with paracetamol in early post-tonsillectomy pain in adults. [2005.10]

Preoperative oral rofecoxib and postoperative pain in patients after laparoscopic cholecystectomy: a prospective, randomized, double-blinded, placebo-controlled trial. [2005.10]

The cyclooxygenase-2 inhibitor rofecoxib (Vioxx((R))) in the treatment of cervical dysplasia grade II-III A phase II trial. [2005.09.24]

A double-blind prospective comparison of rofecoxib vs ketorolac in reducing postoperative pain after arthroscopic knee surgery. [2005.09]

A double-blind, placebo controlled comparison of the morphine sparing effect of oral rofecoxib and diclofenac for acute renal colic. [2005.09]

Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair. [2005.07]

Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies. [2005.06]

TOCOX--a randomised, double-blind, placebo-controlled trial of rofecoxib (a COX-2-specific prostaglandin inhibitor) for the prevention of preterm delivery in women at high risk. [2005.06]

A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. [2005.06]

Renal effects of the cyclooxygenase-inhibiting nitric oxide donator AZD3582 compared with rofecoxib and naproxen during normal and low sodium intake. [2005.05]

The time to onset and overall analgesic efficacy of rofecoxib 50 mg: a meta-analysis of 13 randomized clinical trials. [2005.05]

Preemptive oral rofecoxib plus postoperative intraarticular bupivacaine for pain relief after arthroscopic knee surgery. [2005.04]

Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. [2005.03.17]

Selective COX-2 inhibition with different doses of rofecoxib does not impair endothelial function in patients with coronary artery disease. [2005.02]

Preoperative analgesia management with rofecoxib in thoracotomy patients. [2005.02]

Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs. [2005.02]

Rofecoxib attenuates both primary and secondary inflammatory hyperalgesia: a randomized, double blinded, placebo controlled crossover trial in the UV-B pain model. [2005.02]

A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy. [2005.01]

Combination therapy with rofecoxib and finasteride in the treatment of men with lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). [2005.01]

[Comparison of preemptive analgesia efficacy between etoricoxib and rofecoxib in ambulatory gynecological surgery] [2004.12]

A randomized crossover trial of tenoxicam compared with rofecoxib for postoperative dental pain control. [2004.12]

Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial. [2004.12]

Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib). [2004.12]

Pain management in osteoarthritis: a focus on onset of efficacy--a comparison of rofecoxib, celecoxib, acetaminophen, and nabumetone across four clinical trials. [2004.11]

Comparison of efficacy of oral rofecoxib and ketorolac in controlling early postoperative outpatient orthopedic surgical pain. [2004.10]

Randomized, placebo-controlled trial of rofecoxib in the acute treatment of migraine. [2004.05.11]

Onset of pain relief with rofecoxib in chronic low back pain: results of two four-week, randomized, placebo-controlled trials. [2004.05]

Rofecoxib, a COX-2 inhibitor, lowers C-reactive protein and interleukin-6 levels in patients with acute coronary syndromes. [2004.05]

Rofecoxib versus magnesium sulfate to arrest preterm labor: a randomized trial. [2004.05]

Valdecoxib versus rofecoxib in acute postsurgical pain: results of a randomized controlled trial. [2004.05]

Efficacy and safety of rofecoxib 12.5 mg versus nabumetone 1,000 mg in patients with osteoarthritis of the knee: a randomized controlled trial. [2004.05]

Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry. [2004.05]

Acetylsalicylic acid, diclofenac, and lornoxicam, but not rofecoxib, affect platelet CD 62 expression. [2004.04]

Preoperative oral rofecoxib reduces postoperative pain and tramadol consumption in patients after abdominal hysterectomy. [2004.04]

Perioperative rofecoxib improves early recovery after outpatient herniorrhaphy. [2004.04]

Effect of rofecoxib on platelet aggregation and blood loss in gynaecological and breast surgery compared with diclofenac. [2004.04]

Analgesic efficacy of a single dose of lumiracoxib compared with rofecoxib, celecoxib and placebo in the treatment of post-operative dental pain. [2004.03]

A single-blind, randomized, controlled trial to assess the efficacy and tolerability of rofecoxib, diclofenac sodium, and meloxicam in patients with acute gouty arthritis. [2004.03]

Comparison of some effects of acetylsalicylic acid and rofecoxib during orthodontic tooth movement. [2004.03]

Rofecoxib in the prevention of perimenstrual migraine: an open-label pilot trial. [2004.02]

Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. [2004.01.13]

Efficacy of rofecoxib and nimesulide in controlling postextraction pain in oral surgery: a randomised comparative study. [2004.01]

Preoperative rofecoxib oral suspension as an analgesic adjunct after lower abdominal surgery: the effects on effort-dependent pain and pulmonary function. [2004.01]

A randomized double-blind prospective study evaluating patient tolerance of transrectal ultrasound-guided biopsy of the prostate using prebiopsy rofecoxib. [2003.12]

Rofecoxib does not compromise platelet aggregation during anesthesia and surgery. [2003.12]

Dysmenorrhea treatment with a single daily dose of rofecoxib. [2003.12]

Effect of cyclooxygenase-2 inhibition with rofecoxib on endothelial dysfunction and inflammatory markers in patients with coronary artery disease. [2003.11.19]

Comparative evaluation of the effectiveness and tolerability of nimesulide versus rofecoxib taken once a day in the treatment of patients with knee osteoarthritis. [2003.11]

A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. [2003.10.15]

Gastrointestinal tolerability and effectiveness of rofecoxib versus naproxen in the treatment of osteoarthritis: a randomized, controlled trial. [2003.10.07]

An evaluation of the dose-dependent inhibition of CYP1A2 by rofecoxib using theophylline as a CYP1A2 probe. [2003.10]

A comparative study of the effect of rofecoxib (a COX 2 inhibitor) and naproxen sodium on analgesic requirements after abdominal hysterectomy. [2003.10]

The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. [2003.09]

Interaction of rofecoxib and celecoxib with warfarin. [2003.07.01]

An evaluation of the safety and efficacy of administering rofecoxib for postoperative pain management. [2003.07]

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. [2003.06.04]

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