Vioxx (Rofecoxib) - Summary

VIOXX SUMMARY

Note: VIOXX (rofecoxib) was removed from the US Market in September 2004.

VIOXX is indicated:

For relief of the signs and symptoms of osteoarthritis.

For relief of the signs and symptoms of rheumatoid arthritis in adults.

For the management of acute pain in adults.

For the treatment of primary dysmenorrhea.

For the acute treatment of migraine attacks with or without aura in adults.

The safety and effectiveness of VIOXX have not been established for cluster headache, which is present in an older, predominantly male, population.

See all Vioxx indications & dosage >>

VIOXX NEWS HIGHLIGHTS

Media Articles Related to Vioxx (Rofecoxib)

Vioxx's Heart Risk Lingered Long After Use Ended
Source: MedicineNet Colon Polyps Specialty [2008.10.14]

Vital Vioxx Details 'Manipulated'
Source: MedicineNet rofecoxib Specialty [2008.04.16]

Researchers confirm Vioxx doubled cardiovascular risks in cancer study
Source: The Doctors Lounge - Rheumatology

more >>

Published Studies Related to Vioxx (Rofecoxib)

Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE*3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban). [2008.08.01]

Was the thrombotic risk of rofecoxib predictible from the French Pharmacovigilance Database before 30 September 2004? [2008.08]

The effects of preoperative rofecoxib, metoclopramide, dexamethasone, and ondansetron on postoperative pain and nausea in patients undergoing elective laparoscopic cholecystectomy. [2007.10]

The VIOXX in Prostate Cancer Prevention study: cardiovascular events observed in the rofecoxib 25 mg and placebo treatment groups. [2007.09]

The prolonged postoperative analgesic effect when dexamethasone is added to a nonsteroidal antiinflammatory drug (rofecoxib) before breast surgery. [2007.08]

more >>

Clinical Trials Related to Vioxx (Rofecoxib)

Study of Vioxx and Radiation Therapy for Brainstem Glioma [Terminated]

A Study to Evaluate the Effect of MK0966 (Rofecoxib) on the Recurrence of Colorectal Adenomas [Completed]

A Study of Rofecoxib in the Treatment of Post-Operative Pain After Total Knee Joint Replacement. [Terminated]

A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of the Knee [Completed]

A Study to Evaluate Rofecoxib Versus Placebo and Diclofenac in Patients With Acute Painful Rotator Cuff Syndrome [Terminated]

more >>

VIOXX PATIENT REVIEWS / RATINGS / COMMENTS

Vioxx review by 47 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		possible arthritis
Dosage & duration:		Don't remember (dosage frequency: don't remember) for the period of 3 days
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		Don't believe that I took it long enough to really tell if it was working. I had an allergic reaction shortly after I started taking it.
Side effects:		My upper lip swelled up an became rough an mildly itchy. It remained rough and swollen for a week. For another week it just felt "weird". There was some crustiness around my mouth. Hadn't eaten or taken anything else orally that was new to me.
Comments:		I don't remember the details, but I did follow the prescription directions to the letter. Did not take more than was prescribed to me and took it in the prescribed manner.