Viokase (Lipase / Amylase / Protease) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

VIOKASE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSE

Acute toxicity determinations in animals have not been possible since the maximum dose that could be given orally produced no toxic reaction. In chronic feeding tests rats developed swollen salivary glands. This is believed due to the proteolytic activity and the mucosal irritation caused by tissue digestion.

No acute toxic reactions have been reported.

CONTRAINDICATIONS

Should not be used in patients hypersensitive to pork protein.

REFERENCES

1. Regan PT, Malagelada J-R, DiMagno EP, Gianzman SL, Go VLW. Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. N Engl J Med 1977;297:854-8.
2. Graham DY. Enzyme replacement therapy of exocrine pancreatic insufficiency in man. N Eng J Med 1977;296:1314-7.

VIOKASE® is a registered trademark of Axcan Pharma US Inc.

Rev. February 2003

Manufactured in Canada for:

Axcan Scandipharm Inc.

Birmingham, AL 35242 USA