Media Articles Related to Vinorelbine
Histone demethylase associated with non-small cell lung cancer identified
Source: Lung Cancer News From Medical News Today [2013.11.12]
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer deaths worldwide. Current therapies that target cellular kinases have been effective for some patients: however, many individuals with NSCLS do not respond. Recent studies of other cancers indicate that the global changes in DNA methylation patterns may drive tumor formation.
Metformin could serve as a radiosensitizer to treat patients with stage III non-small cell lung cancer
Source: Lung Cancer News From Medical News Today [2013.10.25]
Treating aggressive lung cancer with the diabetes drug metformin along with radiation and chemotherapy may slow tumor growth and recurrence, suggests new preliminary findings from researchers at the Perelman School of Medicine at the University of Pennsylvania being presented during an oral abstract session October 28 at the 15th World Conference on Lung Cancer.
Stereotactic Body Radiation Beats Standard Tx
Source: MedPage Today Pulmonology [2013.12.02]
CHICAGO (MedPage Today) -- The use of newer stereotactic body radiation therapy appears to give patients with inoperable non-small cell lung cancer significantly improved outcomes when compared with conventional radiotherapy, researchers suggested here.
New side-effect of crizotinib for ALK positive NSCLC
Source: Lung Cancer News From Medical News Today [2013.11.25]
A University of Colorado Cancer Center study published in the journal Cancer shows that using crizotinib to treat ALK positive non-small cell lung cancer (NSCLC) appears to reduce kidney function when assessed by one of the most commonly used clinical methods.
Simple blood test for sub-type specific lung cancer diagnosis
Source: Lung Cancer News From Medical News Today [2013.11.12]
Lung cancer is the leading cause of cancer specific death worldwide. 85% lung cancers are non-small cell lung cancers (NSCLC) while remaining are small cell lung cancers (SCLC). Although X-Ray and CT scan remain the main non-invasive diagnosis strategy, the painful lung tissue biopsy is essential for confirmation and staging of the disease.
Published Studies Related to Vinorelbine
Docetaxel vs. vinorelbine in elderly patients with advanced non--small-cell lung cancer: a hellenic oncology research group randomized phase III study. [2011.05]
BACKGROUND/PURPOSE: This study compared front-line treatment with docetaxel or vinorelbine in elderly patients with advanced/metastatic non-small-cell lung cancer (NSCLC)... CONCLUSIONS: Docetaxel has an efficacy comparable to that of vinorelbine as first-line treatment in elderly patients with NSCLC and has an acceptable toxicity profile. The trial was closed prematurely because of low accrual, thus limiting the strength of the conclusions derived. Copyright (c) 2011. Published by Elsevier Inc.
A multicenter prospective phase II randomized trial of epirubicin/vinorelbine versus pegylated liposomal doxorubicin/vinorelbine as first-line treatment in advanced breast cancer. A GOIM study. [2011.04.12]
BACKGROUND: To evaluate activity and tolerability of two anthracycline-containing regimens as first-line treatment for anthracycline-naive relapsed breast cancer patients... CONCLUSIONS: Both anthracycline- containing regimens evaluated in the present study seem to be active and with a satisfactory tolerability in anthracycline-naive relapsed breast cancer patients.
Paclitaxel and gemcitabine versus paclitaxel and vinorelbine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group (HeCOG). [2011.04]
BACKGROUND: Paclitaxel (Taxol) and vinorelbine have shown synergism of cytotoxic effects in vitro and clinical activity in phase I and II studies. This combination was compared prospectively with the paclitaxel/gemcitabine regimen in non-operable non-small-cell lung cancer... CONCLUSION: Although response rate, PFS and survival were non-different in both groups, toxicity was significantly worse in group B and therefore further investigation of P-Vin is of no value. (c) The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology.
Randomised phase II trial of gemcitabine plus vinorelbine vs gemcitabine plus cisplatin vs gemcitabine plus capecitabine in patients with pretreated metastatic breast cancer. [2011.03.29]
BACKGROUND: An increasing proportion of patients are exposed to anthracyclines and/or taxanes in the adjuvant or neoadjuvant setting. Re-exposure in the metastatic stage is limited by drug resistance, thus evaluation of non-cross-resistant regimens is mandatory... CONCLUSIONS: This randomised phase II trial has revealed comparable results for three gemcitabine-based regimens regarding treatment efficacy and toxicity. Gemcitabine-based chemotherapy appears to be a worthwhile treatment option for pretreated patients with metastatic breast cancer.
Second-line paclitaxel/carboplatin versus vinorelbine/carboplatin in patients who have advanced non-small-cell lung cancer pretreated with non-platinum-based chemotherapy: a multicenter randomized phase II study. [2011.03]
PURPOSE: This study evaluates the activity and toxicity of the paclitaxel/carboplatin (PC) doublet versus vinorelbine/carboplatin (VC) doublet as second-line treatment in patients who have advanced non-small-cell lung cancer (NSCLC)... CONCLUSIONS: Platinum-based doublets with either paclitaxel or vinorelbine in patients with advanced/metastatic NSCLC pretreated with front-line docetaxel/gemcitabine show comparable efficacy when used in the second-line setting. Copyright (c) 2011. Published by Elsevier Inc.
Clinical Trials Related to Vinorelbine
Cetuximab and Vinorelbine in Elderly Subjects With Lung Cancer [Completed]
The purpose of this study is it to determine how well patients with non-small cell lung
cancer respond to cetuximab plus vinorelbine. We would also like to determine the safety of
cetuximab plus vinorelbine in people 70 years of age or older with advanced non-small cell
Trastuzumab in Combination With Vinorelbine or Taxane-Based Chemotherapy in Patients With Metastatic Breast Cancer [Completed]
The purpose of this study is to compare two different combinations of chemotherapy with
trastuzumab as initial treatment for HER2 positive advanced breast cancer. Half of the
patients will receive trastuzumab in combination with a taxane form of chemotherapy (either
paclitaxel or docetaxel), while the other group will receive trastuzumab in combination with
Vinorelbine/Gemcitabine Verses Vinorelbine/Carboplatin in Advanced Non-Small Cell Lung Cancer [Recruiting]
BIBW 2992 and Vinorelbine in Tumours Known to Overexpress EGFR and/or HER2 [Recruiting]
To identify the MTD of BIBW 2992 therapy in combination with vinorelbine i. v. and oral
Safety and anti-tumour efficacy data and determination of pharmacokinetic characteristics of
BIBW 2992, vinorelbine i. v. and vinorelbine oral.
Lapatinib + Vinorelbine in ErbB2 Overexpressing, First or Second Line Metastatic Breast Cancer Subjects [Recruiting]
This is an open-label, single-arm, multi-center, Phase II study to determine the activity of
vinorelbine plus lapatinib in either first- or second-line setting in women with ErbB2
overexpressing metastatic breast cancer (MBC). Sixty subjects will be enrolled in the
study. Subjects will receive vinorelbine intravenously once weekly for 3 weeks, followed by
a rest week in a 4-week cycle) plus lapatinib daily. Subjects will receive treatment until
disease progression or withdrawal from the study. The primary objective of this study is to
evaluate overall tumor response rate of lapatinib in combination with vinorelbine.
Secondary objectives include progression-free survival, overall survival, duration of
response, time to response and time to progression and safety. Safety and efficacy
assessments will be performed at 4, 8 and 12 week intervals, and at the end of treatment.
Subject: Metastatic Breast Cancer, ErbB2, First-line or Second-line therapy, Lapatinib,
Reports of Suspected Vinorelbine Side Effects
Hepatic Failure (22),
Neutropenic Sepsis (21),
Febrile Neutropenia (20),
Interstitial Lung Disease (15),
Constipation (11), more >>