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Vicodin (Hydrocodone Bitartrate / Acetaminophen) - Summary

 
 



VICODIN SUMMARY

VICODIN®
(hydrocodone bitartrate and acetaminophen tablets, USP)
5 mg/500 mg
CS-III

Hydrocodone bitartrate and acetaminophen is supplied in tablet form for oral administration.

VICODIN tablets are indicated for the relief of moderate to moderately severe pain.


See all Vicodin indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Vicodin (Hydrocodone / Acetaminophen)

Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial. [2008.01]
OBJETIVES: The purpose of this study was to compare the analgesic efficacy and tolerability of opioids hydrocodone and tramadol in the relief of cancer pain... CONCLUSIONS: There was no superior analgesic efficacy with the administration of hydrocodone/acetaminophen when compared to patients receiving tramadol in the relief of cancer pain. Tramadol produced more mild side effects than hydrocodone.

Tramadol/acetaminophen or hydrocodone/acetaminophen for the treatment of ankle sprain: a randomized, placebo-controlled trial. [2007.04]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.

Tramadol/Acetaminophen or Hydrocodone/Acetaminophen for the Treatment of Ankle Sprain: A Randomized, Placebo-Controlled Trial. [2006.11.17]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.

Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery. [2006.04]
OBJECTIVES/HYPOTHESIS: Functional endoscopic sinus surgery (FESS) is less invasive and more tissue sparing than extirpative techniques, with an assumed benefit of diminished postoperative pain. Oral opioids are commonly prescribed after sinus surgery but are associated with adverse effects, including gastrointestinal and neurologic symptoms. Nonopioid analgesics have been suggested to offer similar pain control efficacy with fewer adverse effects. STUDY DESIGN: To investigate postoperative analgesia in FESS, a prospective randomized, double-blinded comparison of hydrocodone/acetaminophen 7.5/750 mg (an opioidderivative) with rofecoxib 50 mg (a cyclooxygenase-2 inhibitor) was performed... CONCLUSIONS: The use of nonopioid analgesics after FESS may provide similar pain control to oral opioids.

Profiling the subjective, psychomotor, and physiological effects of a hydrocodone/acetaminophen product in recreational drug users. [2005.06.01]
BACKGROUND: Hydrocodone (HYD) is a mu opioid agonist. Hydrocodone/acetaminophen HYD/ACET compounds are both widely prescribed and abused prescription painkillers in the United States. In the present study, we profiled the subjective, psychomotor, and physiological effects of the compound. It was of particular interest to determine if HYD/ACET had abuse liability-related subjective effects in a population of recreational drug users... CONCLUSIONS: HYD/ACET produced some abuse liability-related subjective effects in recreational drug users, which is consistent with the widespread non-medical use and abuse of this product.

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Clinical Trials Related to Vicodin (Hydrocodone / Acetaminophen)

A Study Comparing VicodinŽ CR and NORCOŽ to Placebo in Subjects With Acute Pain Following Bunionectomy [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of Extended Release Hydrocodone/Acetaminophen and Immediate Release Hydrocodone/Acetaminophen with placebo over a 12 hour dosing period in patients who have had a bunionectomy, and to assess the safety of the drug for 7 days after patients are discharged from the hospital.

Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco [Recruiting]
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.

A Study to Evaluate the Interaction Between VicodinŽ CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers [Completed]

A Study Comparing the Analgesic Activity of Extended Release Hydrocodone/Acetaminophen (VicodinŽ CR) and Placebo in Subjects With Pain Following Bunionectomy Surgery [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of 2 different dose levels of Extended Release Hydrocodone/Acetaminophen with placebo over a 48 hour dosing period in patients who have had bunionectomy surgery, and to assess the safety of the drug for 7 days after patients are discharged from the hospital.

A Study of Extended-Release Hydrocodone/Acetaminophen (Vicodin CRŽ) in Subjects With Acute Pain Following Bunionectomy [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of Extended-Release Hydrocodone/Acetaminophen compared to placebo over a 48 hour dosing period in patients who have had bunionectomy surgery and to assess the safety of the drug for 7 days after patients are discharged from the hospital.

more trials >>

Reports of Suspected Vicodin (Hydrocodone / Acetaminophen) Side Effects

Vomiting (59)Drug Ineffective (56)Nausea (54)Drug Hypersensitivity (44)Pain (31)Headache (28)Constipation (28)Dizziness (28)Insomnia (28)Feeling Abnormal (24)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 23 ratings/reviews, Vicodin has an overall score of 6.30. The effectiveness score is 8.26 and the side effect score is 6.96. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Vicodin review by 26 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   post surgery stomach pain
Dosage & duration:   2 pills taken once for the period of one day
Other conditions:   fever
Other drugs taken:   none
  
Reported Results
Benefits:   The pain subsided very quickly with no side effects.
Side effects:   none.
Comments:   After a surgery to remove ovarian cysts, I was left with pain in my stomach and lower back. The Hydrocodone/acetaminophen pills were prescribed and were very effective in getting rid of the pain, with no side effects.

 

Vicodin review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   I got my toothpulled
Dosage & duration:   1 or 2 pills as needed taken twice for the period of 1 day
Other conditions:   None
Other drugs taken:   Antibiotics
  
Reported Results
Benefits:   I took the drug shortly after having my tooth pulled. I never noticed a great amount of pain, and contribute this to the laughing gas and novicane during the proceduce, and taking the vicadin shortly after the procedure. I took the vicadin drug twice because after several hours I started to feel pain again. It was effective in reliefing my pain.
Side effects:   After taking the drug, I became sick to my stomach. I threw up everything that I had consumed prior to the procedure. This feeling stayed with me for several hours. I initally thought I was sick, because I did not eat when I took the first dosage. I then took another dose, but this time I made myself eat a little something, (I could not eat much at this point), but it mattered not...I got sick again. I threw the rest of the presciption out.
Comments:   The prescription was given to me prior to having my tooth pulled. I never filled the prescription because I really did not notice any pain. After the procedure, I immediately went to have the prescription filled. I took the medication while I was still numb from the novicane. As the novicane wore off, and the two tablets I took wore off, I took the vicadine once again.

 

Vicodin review by 56 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   nausea, headaches, dizziness
Dosage & duration:   5 mg ????? taken as needed for pain for the period of 3 days
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   reactions over-road the benefits. I will simply say that I did not think I received benefits from this particular drug. There are other pain inhibitors that worked as well as the vicodin with out the druggy feelings and sickness.
Side effects:   headaches, nausea, druggy feelings, heaviness, just an overall sense of malaise. Felt like I was in a drug induced stupor. Very uncomfortable and unacceptable.
Comments:   to control pain after surgery

See all Vicodin reviews / ratings >>

Page last updated: 2008-03-26

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