VICODIN SUMMARY
VICODIN®
(hydrocodone bitartrate and acetaminophen tablets, USP)
5 mg/500 mg
CS-III
Hydrocodone bitartrate and acetaminophen is supplied in tablet form for oral administration.
VICODIN tablets are indicated for the relief of moderate to moderately severe pain.
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NEWS HIGHLIGHTSMedia Articles Related to Vicodin (Hydrocodone / Acetaminophen)
hydrocodone/acetaminophen, Vicodin, Vicodin ES, Anexsia, Lorcet, Lorcet Plus, Norco
Source: MedicineNet Coccydynia Specialty [2008.01.07]
Title: hydrocodone/acetaminophen, Vicodin, Vicodin ES, Anexsia, Lorcet, Lorcet Plus, Norco
Category: Medications
Created: 12/31/1997
Last Editorial Review: 1/7/2008
Published Studies Related to Vicodin (Hydrocodone / Acetaminophen)
Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial. [2008.01]
OBJETIVES: The purpose of this study was to compare the analgesic efficacy and tolerability of opioids hydrocodone and tramadol in the relief of cancer pain... CONCLUSIONS: There was no superior analgesic efficacy with the administration of hydrocodone/acetaminophen when compared to patients receiving tramadol in the relief of cancer pain. Tramadol produced more mild side effects than hydrocodone.
Tramadol/acetaminophen or hydrocodone/acetaminophen for the treatment of ankle sprain: a randomized, placebo-controlled trial. [2007.04]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.
Tramadol/Acetaminophen or Hydrocodone/Acetaminophen for the Treatment of Ankle Sprain: A Randomized, Placebo-Controlled Trial. [2006.11.17]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.
Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery. [2006.04]
OBJECTIVES/HYPOTHESIS: Functional endoscopic sinus surgery (FESS) is less invasive and more tissue sparing than extirpative techniques, with an assumed benefit of diminished postoperative pain. Oral opioids are commonly prescribed after sinus surgery but are associated with adverse effects, including gastrointestinal and neurologic symptoms. Nonopioid analgesics have been suggested to offer similar pain control efficacy with fewer adverse effects. STUDY DESIGN: To investigate postoperative analgesia in FESS, a prospective randomized, double-blinded comparison of hydrocodone/acetaminophen 7.5/750 mg (an opioidderivative) with rofecoxib 50 mg (a cyclooxygenase-2 inhibitor) was performed... CONCLUSIONS: The use of nonopioid analgesics after FESS may provide similar pain control to oral opioids.
Profiling the subjective, psychomotor, and physiological effects of a hydrocodone/acetaminophen product in recreational drug users. [2005.06.01]
BACKGROUND: Hydrocodone (HYD) is a mu opioid agonist. Hydrocodone/acetaminophen HYD/ACET compounds are both widely prescribed and abused prescription painkillers in the United States. In the present study, we profiled the subjective, psychomotor, and physiological effects of the compound. It was of particular interest to determine if HYD/ACET had abuse liability-related subjective effects in a population of recreational drug users... CONCLUSIONS: HYD/ACET produced some abuse liability-related subjective effects in recreational drug users, which is consistent with the widespread non-medical use and abuse of this product.
Clinical Trials Related to Vicodin (Hydrocodone / Acetaminophen)
A Study Comparing VicodinŽ CR and NORCOŽ to Placebo in Subjects With Acute Pain Following Bunionectomy [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of Extended Release Hydrocodone/Acetaminophen and Immediate Release
Hydrocodone/Acetaminophen with placebo over a 12 hour dosing period in patients who have had
a bunionectomy, and to assess the safety of the drug for 7 days after patients are discharged
from the hospital.
A Study to Evaluate the Interaction Between VicodinŽ CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers [Completed]
A Study Comparing the Analgesic Activity of Extended Release Hydrocodone/Acetaminophen (VicodinŽ CR) and Placebo in Subjects With Pain Following Bunionectomy Surgery [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of 2 different dose levels of Extended Release
Hydrocodone/Acetaminophen with placebo over a 48 hour dosing period in patients who have had
bunionectomy surgery, and to assess the safety of the drug for 7 days after patients are
discharged from the hospital.
A Study of Extended-Release Hydrocodone/Acetaminophen (Vicodin CRŽ) in Subjects With Acute Pain Following Bunionectomy [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of Extended-Release Hydrocodone/Acetaminophen compared to placebo over
a 48 hour dosing period in patients who have had bunionectomy surgery and to assess the
safety of the drug for 7 days after patients are discharged from the hospital.
A Study Comparing the Analgesic Efficacy and Safety of Extended Release Hydrocodone/Acetaminophen (VicodinŽ CR)and Placebo in Subjects With Osteoarthritis [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of Extended Release Hydrocodone/Acetaminophen with placebo over a
5-week dosing period in patients with osteoarthritis.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 16 ratings/reviews, Vicodin has an overall score of 6.56. The effectiveness score is 8 and the side effect score is 6.75. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Vicodin review by 26 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | post surgery stomach pain |
| Dosage & duration: | | 2 pills taken once for the period of one day |
| Other conditions: | | fever |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The pain subsided very quickly with no side effects. |
| Side effects: | | none. |
| Comments: | | After a surgery to remove ovarian cysts, I was left with pain in my stomach and lower back. The Hydrocodone/acetaminophen pills were prescribed and were very effective in getting rid of the pain, with no side effects. |
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| | Vicodin review by 45 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | molar extraction |
| Dosage & duration: | | one tablet every three hours taken one week for the period of one week |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | I felt no pain from the extraction on the Vicodin. |
| Side effects: | | While taking Vicoden, I was very dizzy and sleepy. I was unable to drive or function at a normal level. |
| Comments: | | I was given a prescription for the first week with an option to refill. I did not refill because I was not in a lot of pain and didn't want to continue to experience the side effects. |
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| | Vicodin review by 35 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | shoulder & neck pain |
| Dosage & duration: | | 5/500 mg taken 1 tablet/day for the period of 1 day |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | None. Vicodin is a narcotic for severe pain. I was prescribed it after weeks of physical therapy and ibuprophin did not reduce the pain in my shoulder and neck following a ski crash. |
| Side effects: | | Much to my dismay, the drug made me feel extremely nauseated. Though I did not actually throw up, I felt like it for a day. Furthermore, the pain in my neck and shoulder did not improve. Even if it had, I would have discontinued Vicodin anyway. |
| Comments: | | My doctor did not mention any possible side effects, nor did he tell me it is a narcotic. Apparently, it is a drug of abuse. Also, nausea is a common side effect. I was only told that it was a pain killer that would alleviate my discomfort. |
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Page last updated: 2008-03-26
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